Epidemiological studies demonstrate a close relationship between psoriasis and concomitant metabolic diseases, including obesity, hypertension, diabetes mellitus, dyslipidemia, and non-alcoholic fatty liver disease. The presence of concomitant metabolic diseases has a significant impact on the choice and effectiveness of pharmacological treatment. Due to the increased risk of adverse events in patients with psoriasis and comorbidities, some drugs should be prescribed with special caution, while some drugs show low efficacy. The IL‑23 inhibitor guselkumab may be a better therapeutic alternative for patients with psoriasis and metabolic disorders, including obesity, compared with disease-modifying antirheumatic drugs (such as methotrexate, acitretin) and other classes of biological drugs. In patients with moderate to severe psoriasis, the IL‑23 inhibitor guselkumab shows a high treatment outcome with PASI 90 and PASI 100 achieved, regardless of BMI. The presented publication describes observations of patients with moderate to severe psoriasis, comorbidities and high efficiency of genetically engineered biological therapy with an IL‑23 inhibitor (guselkumab).

Rosacea is a chronic inflammatory skin disease of the face, characterized by extreme prevalence, long-term recurrent course and slow rehabilitation of patients. Multifactorial genesis of this disease determines the validity of the use of combined methods of therapy using local therapy agents with proven effectiveness in combination with physiotherapeutic techniques that affect the restoration of microcirculation and the elimination of residual erythema. The article presents data from a comparative observational study aimed at determining the effectiveness and tolerability of combined therapy for papulopustular rosacea using 1% metronidazole gel (Metrogyl Gel), as well as photo- and laser therapy. As a result of examination and treatment of 87 patients, it was shown that rosacea is characterized by pronounced disturbances of facial skin microcirculation. The use of an external drug with anti-inflammatory activity and modern hardware technologies helps to reduce the time to achieve a clinical effect, good tolerability of therapy and normalization of regional blood flow.

The article presents the application of lipofilling as an innovative method of treating of the vulvar lichen sclerosus (VLS). The main methods of treating VLS are often accompanied by side effects, relapses, or limited effectiveness in the progression of the disease. In this context, lipofilling based on autologous adipose tissue transplantation attracts attention as a promising minimally invasive therapeutic approach. The results of the conducted clinical study confirm the effectiveness of autolipophilling in the treatment of VLS. The obtained research results showed that autolipophilling is a promising method of treating of the vulvar lichen sclerosus, which not only effectively eliminates the symptoms, but also restores the structure of tissues, improving their elasticity and appearance. However, additional research is needed to standardize therapeutic approaches, confirm the effectiveness of the method, and ensure long-term safety.

Introduction. Pemphigus is known to be a life-threatening genetically predisposed autoimmune condition characterized by the formation of IgG antibodies to desmogleins 1 and 3 (Dsg 1, 3) in stratum spinosum and granulosum resulting in blister formation. HLA I and II class antigens express on a vast variety of immune cells including dendritic cells, macrophages, monocytes, Langerhans cells, endothelial cells, and thymic epithelial cells and, therefore play a crucial role in disease’ pathogenesis. The association of pemphigus with HLA alleles has been confirmed through sequencing and genotype analysis across various ethnic groups. In global population the disease development is significantly influenced by specific genetic factors, particularly the HLA alleles DRB1*04:02, DRB1*14:01, DRB1*14:04, and DQB1*05:04. A significant role in the development of pemphigus is attributed to haplotypes, which are combinations of alleles (gene variants). Notably, that the prevalence of DRB 1/DQB 1 haplotypes among patients with pemphigus, as well as their potential association with the disease severity and steroid-resistance in Russian population, has yet to be investigated.

The aim of study. To evaluate the prevalence of HLA-DRB1-HLA-DQB1 haplotypes at low-resolution level in pemphigus patients and their potential association with the disease severity and reluctance to systemic steroid therapy.

Materials and methods. A total of 106 patients with confirmed diagnosis of pemphigus were genotyped for HLA class II genotypes. HLA frequencies were compared with unrelated healthy blood donors (n=92). Disease severity was assessed by PDAI index. The presence of steroid resistance was analyzed using the Murrell consensus from 2008. HLA typing was performed via PCR reaction. The statistical significance of differences between patients and controls was evaluated using Fisher’s exact test.

Results. We found that DRB1*04/DQB1*05 and DRB1*14/DQB1*03 haplotypes predisposed to disease progression in Russian population (p<0,00067; p<0,008643). Moreover, patients who carried these haplotypes showed a tendency towards moderate and severe disease course. However, no statistically significant differences were found for these characteristics. It is also important to highlight that DRB1*11/DQB1*03 haplotype was found exclusively in healthy volunteers indicating its protective role against pemphigus in Russian population.

The study of the skin microbiome has come a long way from the first microscopic observations to a comprehensive molecular analysis of microbial communities and their functions using cutting-edge research methods. It has been established that changes in the microbiome in acne are accompanied by a decrease in the diversity of Curibacterium acnes, as well as an increase in the virulence properties of the resident biota with the formation of predisposing factors for the colonization of the skin by pathogenic microorganisms. The studies have shown that the effectiveness of systemic isotretinoin in the treatment of patients with acne is accompanied by an increase in the diversity of C. acnes phylotypes in the follicular microbiome, normalization of the metabolic activity of bacteria and a decrease in their number on the skin surface in the affected areas.

Alopecia areata is an autoimmune inflammatory disease characterized by non-scarring hair loss. This review summarizes current data on disease pathogenesis and systemic JAK inhibitor therapy in pediatric patients. Special attention is given to selective agents and their safety in children with severe alopecia areata.

Severe forms of congenital epidermolysis bullosa (CEB) are associated with numerous complications, among which nutritional deficiency holds particular significance. Despite the existence of both national and international guidelines for diagnosing and treating nutritional deficiency in patients with CEB, a unified algorithm for detecting nutritional disorders in this disease remains unavailable.

Purpose of the study. To develop and perform an initial validation of a comprehensive quantitative scale for assessing nutritional deficiency, integrating clinical, laboratory, and instrumental parameters that most accurately reflect the nutritional status of patients with CEB.

Methods. The study included 50 patients (23 males and 27 females) with a confirmed diagnosis of congenital epidermolysis bullosa, aged 5 to 17 years and 11 months (M = 11.8 ± 3.2 years). Development of the Nutritional Deficiency Assessment Scale (NDAS) was based on the Birmingham Epidermolysis Bullosa Severity (BEBS) index, as well as laboratory and anthropometric indicators. Cronbach’s alpha coefficient was employed to evaluate internal consistency, while intraclass correlation (ICC) was used to determine reliability by comparing scale results upon patient admission and 10 days later. Criterion validity was assessed using Pearson’s correlation coefficient (r) between the NDAS and the BEBS and THINC scales.

Results. The findings indicate that the NDAS demonstrates favorable psychometric properties. Internal consistency (Cronbach’s α = 0.85) and test-retest reliability (ICC = 0.88) confirm its stability and uniformity. Criterion validity, assessed through correlation with existing scales (BEBS, THINC), revealed significant positive relationships (r > 0.70; p < 0.001).

Conclusions. The NDAS integrates both objective measures and disease-specific clinical features, reflecting a comprehensive approach to evaluating the nutritional status of patients with CEB. The present study supports the NDAS as a reliable and easy-to-use tool for diagnosing and predicting nutritional risks in patients with CEB.

Objective. Formulation and explication of the principles of high-frequency multiparametric ultrasound examination of the dermal skin layer. Description of the algorithm for ultrasound examination of the dermal skin layer using high-frequency ultrasound probes.

Materials and Methods. Data on the structure of the dermal skin layer were obtained from 36 patients using high-frequency ultrasound probes (18.0–24.0 MHz) from different manufacturers: LA435/SL3116 (Esaote) and i18LX5/i24LX8 (Canon).

Results. The study evaluated the capabilities of high-frequency ultrasound probes for assessing the thickness and structure of the dermal skin layer. An algorithm for multiparametric ultrasound examination of the dermal skin layer was described.

Conclusions. The principles of multiparametric ultrasound examination of the dermal skin layer were established based on the study findings. These principles enable the effective use of high-frequency ultrasound for differentiation and evaluation of the examined structures.

With age, the skin undergoes changes, losing elasticity, moisture and protective functions, which contributes to the appearance of various dermatoses. Dermatological diseases are quite common in geriatric patients and may have their own course characteristics in this age group. The study of the features and structure of dermatoses in geriatric patients is important for the development of effective methods of treatment and prevention of these diseases.

Background. Vulgar acne is one of the most common dermatoses, affecting up to 85% of people aged 12 to 24 years. Four main links are distinguished in the pathogenesis of the disease, including inflammation and pathogenic activity of cutibacteria (Cutibacterium acnes), as well as other microorganisms (Staphylococcus and Malassezia spp).

Objective of the study. To study the facial skin microbiome in patients with moderate acne using gas chromatography-mass spectrometry before and after therapy with a fixed combination of «benzoyl peroxide (BP) 5% + clindamycin 1%» in combination with photodynamic therapy. Materials and methods. The skin microbiome of 40 patients (24 men, 16 women) with an established diagnosis of moderate acne was studied using gas chromatography-mass spectrometry (GC–MS) before and after (3 months) therapy. By randomization, two therapeutic groups were formed in equal numbers and gender ratios (12 men and 8 women, respectively) – the main group, which received a fixed combination of «benzoyl peroxide 5% + clindamycin 1%» (Zerkalin Intensive gel) in combination with photodynamic therapy, and a comparison group (monotherapy with «Zerkalin Intensive» gel). In addition to the qualitative and quantitative analysis by microorganism types, an assessment was made of the ratio of results for grouped microorganisms (loads of resident, transient, aerobic, anaerobic biota, loads of gram-positive and gram-negative bacteria, total bacterial load).

Results. It was found that in patients with acne, the total bacterial load (TBL) in the compared groups was exceeded by 8% and 7.9%, respectively. In both therapeutic groups, pronounced dysbiosis was revealed, which was characterized by an imbalance between total aerobes and anaerobes. Contamination with the former was exceeded by 310.6% (group I) and 187.5% (group II) (p<0.05), and the contamination with anaerobes, on the contrary, was reduced by 6.9% in group I and increased by 21.3% in group II (p><0.005). The total number of gram-positive bacteria was exceeded by 21.4% (group I) and 9.7% (group II) (p><0.05), gram-negative bacteria were reduced by 90.1% and 89.9% (p>0.5), respectively. At the end of 3 months of treatment, the quantitative indices of all six aerobes and four anaerobes of the resident microbiota in both groups returned to values close to the normative indices characteristic of healthy skin (p> 0.05). The greatest reduction in both therapeutic groups was observed in Propionibacterium spp. (by 90.4% and 78.8%, respectively (p<0.05)). A more pronounced reduction in the colonies of anaerobes of the transient microbiota over 12 weeks of therapy was observed in the main therapeutic group: Propionibacterium acnes was in the lead (78.4% versus 68.9% in group II, p><0.05). In the main therapeutic group, the reduction in resident biota contamination slightly prevailed over that in the comparison group (70.5% in group I and 68.9% in group II (p> 0.05).

Conclusion. Treatment of patients with moderate acne using a fixed combination of «benzoyl peroxide 5% + clindamycin 1%» in combination with photodynamic therapy has a significantly more pronounced effect on the elimination of anaerobes of both resident and transient microbiota.

The basis of acne pathophysiology is hormonal stimulation of the sebaceous glands and the formation of follicular hyperkeratosis. Currently, there is a lot of data on hormonal abnormalities in acne in women, but there are no systematic studies on hormonal and metabolic abnormalities in general in men and women and their relationship with acne development.

The aim of this study was to optimize the data on hormonal and metabolic abnormalities in acne in women and men.

Material and methods. 230 patients were observed, the median age was 21.0 [19.0; 22.0] years: in men – 20.0 [20.0; 22.0] (n = 129), in women – 22 [20.0; 23.0] (n = 101). The study included a dermatological examination with determination of the GAGS severity index, a biochemical blood test, and an assessment of the hormonal status of patients. Upon completion of the examination data registration, a comparative and correlation analysis of the results was performed.

Study results. It was found that in men with acne, hormonal and metabolic abnormalities are recorded in half of the patients and are characterized by the predominant formation of dyslipidemia and a significant increase in DHT and total testosterone. In women, hormonal and metabolic abnormalities were manifested by impaired glucose metabolism, an increase in LH and total testosterone, which were noted in a third of patients. The identified hormonal and metabolic status disorders directly correlated with the severity of the disease and did not depend on the age of the patients.

This article presents data on periorbital hyperpigmentation. A correlation analysis was performed and a new classification of periorbital hyperpigmentation was proposed depending on the predominance of pigmented and vascular components, as well as a classification by severity depending on the severity of symptoms, according to the developed visual analog scale.

Chemotherapy causes Chemotherapy-induced alopecia by early apoptosis of keratinocytes in the follicle. One of the most effective methods of combating cytotoxic alopecia is the cooling system of the scalp. The essence of the method is to use cooling materials at the time of chemotherapy to cause vasoconstriction on the scalp, which in turn leads to a decrease in blood flow and lymph flow in the follicle and causes a decrease in the concentration of the chemotherapy drug in the cooling area. The review presents current data on cryoprophylaxis of chemotherapy-induced alopecia in patients with non-metastatic breast cancer. The success rate of the method was estimated for hair loss of less than 50%. The effectiveness of the method varies between 50–70%, but depends on the type and dose of the drug, the exposure time to scalp cooling, and the individual characteristics of the patient. The best treatment rates for anagenetic alopecia were in patients receiving taxane-based chemotherapy. Among the adverse effects, patients noted cold sensations, dizziness, and soreness of the scalp and face. The advantages and disadvantages of the method were studied.

Introduction. Diagnosis of anogenital psoriasis is complicated by the lack of awareness of doctors and the shyness of patients. The total lesion area and the severity of anogenital psoriasis are often in inverse proportion, which requires the use of systemic therapy. Aim. To present our experience of netakimab monotherapy in anogenital psoriasis.

Materials and methods. 31 adult patients (n=31) with anogenital psoriasis were under observation. The severity of the psoriatic lesion was determined using index sPGA-G (static Physician’s Global Assessment of Genitalia). The assessment was carried out before the start of treatment and then every 4 weeks up to 52 weeks. All patients on an outpatient basis received interleukin‑17 inhibitor (IL‑17) monotherapy with netakimab at a dose of 120 mg in the form of two subcutaneous injections of 1 ml (60 mg) of the drug, each administered once a week at weeks 0, 1 and 2, then 1 time every 4 weeks. The total duration of treatment for each patient was 52 weeks. Dermatological Quality of Life Index (DLQI) were determined by questionnaires before the start of treatment, at the 12th and 52nd weeks. The safety of netakimab was evaluated based on the development of adverse events and local reactions to the administration of the drug.

Results. The results of the study for 52 weeks showed high efficacy of netakimab. 48.4% of patients achieved complete clinical recovery (sPGA0) after 12 weeks of treatment, 67.7% after 24 weeks, and 77.4% after 52 weeks, the quality of their life improved by 6,6 times. There weren’t any cases of early withdrawal due to adverse events and cases of serious adverse events.

Conclusion. Based on the study results we recommend netakimab for treatment of patients with anogenital psoriasis.

Purpose of the study. To study the characteristics of OSA in children with psoriasis, as well as diseases that affect its etiopathogenesis (chronic pathology of ENT organs) and comorbidities (overweight and obesity).

Materials and methods. An open, prospective, observational, cohort, single-center clinical study was conducted at the Department of Dermatology and Allergology of the Research Institute of Pediatric Dermatology, the Department of Instrumental Diagnostics of the Federal State Autonomous Institution «National Medical Research Center of Children’s Health» of the Ministry of Health of the Russian Federation from October 2023 to March 2025. An analysis of clinical (collection of complaints, anamnesis, examination) and paraclinical indicators (pediatric sleep questionnaire (PSQ), polysomnography (PSG), standard deviations of the body mass index – standard deviation score (SDS BMI)) was performed, and a consultation of a pediatric endocrinologist and an otolaryngologist was organized for 89 children aged 3 to 17 years with moderate or severe psoriasis vulgaris.

Results. According to the children’s sleep questionnaire PSQ, OSA was diagnosed in 62.9% of children with psoriasis, and according to the PSG results, only 21% of patients had this pathology, which is significantly more common than in the general population (1–5%). In 74% of cases, OSA was mild, in 16% – moderate, and in 10% – severe. This sleep disorder was significantly associated with excess body weight (p = 0.009) and chronic ENT pathology (p = 0.008).

Conclusions. OSA is quite common in children with psoriasis and is associated with excess body weight and ENT pathology. Correction of diseases that affect the etiopathogenesis of psoriasis, as well as those that are its comorbidities and lead to OSA can contribute to increased treatment effectiveness and improved prognosis for children with this pathology.

Relevance. Authors have repeatedly corresponded about cases indicating a link between localized scleroderma and malignant diseases. However, there are very few studies of associations with specific types of cancer.

Goal. To study the types of malignant diseases associated with localized scleroderma.

Materials and methods. A retrospective study was conducted of 69 cases of tumor-associated scleroderma treated in 2022–2023. The average age of the patients was 64.6±1.72 years. The time interval between the onset of two diseases is no more than 10 years.

Results. More often than others, there is an association with breast cancer (36.23%), uterine body cancer (14.71%), ovarian cancer (13.04%) and basal cell carcinoma (11.77%). In most cases, the malignant process made its debut first. Skin symptoms manifested primarily in all cases of basal cell carcinoma of the skin, thyroid cancer, rectal ampoule cancer. Cases of breast cancer and uterine cancer demonstrate both the primary debut of oncology and localized scleoderma. It was revealed that an average of 5.82±1.2 years elapse between the manifestation of the malignant process and the clinical signs of localized scleroderma. With the primary clinical manifestation of the skin process, an average of 4.13±1.22 years pass before the detection of oncology. In cases of chemotherapy, 6.3 ± 1.96 years pass before the manifestation of the skin process.

Conclusion. Understanding the clinical features of the tumor-associated form of localized scleroderma will help in early diagnosis, prolongation and improvement of the quality of life of patients.

Purpose of the study. Mycosis fungoides (MF) is a tumor transformation of T-lymphocytes of the skin and belongs to cutaneous T-cell lymphomas. The etiology and pathogenesis of MF are unknown; early diagnosis based only on examination of the patient is difficult due to the variety of skin elements in MF. Cases of the development of malignant neoplasms of various localizations in patients with MF due to the developing deficiency of the T-cell component of immunity have been described. The scientific literature contains few descriptions of cases of the development of MF in patients with a history of melanoma.

Materials and methods. The presented work examines a clinical case of the development of MF in an 82-year-old woman 4 years after diagnosis and surgical treatment of superficial spreading melanoma of the skin.

Results. For the purpose of diagnosing MF and differential diagnosis with other skin pathologies, the use of immunohistochemical research is optimal.

Conclusions. The presented clinical case shows the need for long-term, possibly lifelong, observation of patients with a history of melanoma by a dermatologist, as well as the manifestation of oncological vigilance by doctors of other specialties in order to prevent the development of malignant neoplasms of the skin and other organs.

Objective. To analyze the therapeutic efficacy of the combined use of NOVACUTAN YBio and SBio drugs for the correction of a wide range of dermatological disorders. Based on the data obtained, we recommend the inclusion of these products in post-procedural rehabilitation after aggressive cosmetic procedures (laser resurfacing, chemical peels), as well as for dyschromia, signs of photoaging, decreased skin tone and turgor, dull uneven complexion, dehydration and peeling of the epidermis, and skin microrelief disorders.

Materials and methods. Clinical experience in the use of NOVACUTAN YBio/SBio and NOVACUTAN BTA exoprotectors according to the «Beaty flash» and «High-light» protocols.

Results. Injectable exoprotectors are effective as a therapeutic agent for repairing photo-damaged skin, as well as for protecting it from exposure to light, including UVA and UVB rays.

Conclusion. Based on the results obtained, we recommend using exoprotectors during the recovery period after aggressive cosmetic procedures, as well as as a therapeutic agent against photoaging of the facial skin.

Material and methods. We observed 20 female patients aged 30 to 40 years (median 36.7±1.9 years) who came to the appointment with complaints of involutional changes in the facial skin (xerosis, decreased turgor, wrinkles). All patients underwent injection therapy procedures: Lenisna – facial contouring (temporal area, cheek area, chin), JuveLook – for the periorbital area. Efficiency was assessed using the SASSQ scale, qualitative characteristics of the skin (hydration, elasticity, severity of wrinkles).

Results of the study. The dynamics of the SASSQ scale was 45.6%, skin hydration increased almost 2 times, the elasticity index increased by 41.7%, the «severity of wrinkles» index decreased by 16.7%.

Conclusion. The use of Lenisna and JuveLook preparations containing PDLLA and HA allows to significantly improve the qualitative characteristics of the skin and restore tissue volume in case of involutional changes.

In the structure of all post-acne, atrophic scars (AR) and stagnant post-inflammatory erythema, which is essentially the initial stage of scar formation, make up the main part. According to our observations, post-inflammatory hyperpigmentation, described in the literature as one of the common symptoms of post-acne, is much less common. Therefore, the issues of therapy and prevention of AR are still relevant and require an individual approach, taking into account, among other things, anamnestic, morphological and clinical signs of scar tissue. Taking into account the heterogeneity of the clinical manifestations of post-acne atrophic scars and the fact that they often occur against the background of inflammatory acne, treatment should include classical dermatotherapy, including the use of systemic retinoids in various dosages and several types of laser exposure in parallel or alternating sessions. A combination of «vascular» and fractional ablative lasers is promising from the point of view of the effectiveness of acne therapy and the prevention of the appearance of new post-acne, which is confirmed by a series of our observations. The article proposes a methodology for choosing treatment tactics and preventive measures for acne and post-acne atrophic scars based on the analysis of clinical and anamnestic correlations and improved criteria.

Relevance. Treatment of the upper arms is associated with certain difficulties, since soft tissues are not connected with the underlying supporting structures, are often thin and do not have a large amount of fat. In this regard, the comprehensive use of laser therapy in the early postoperative period is promising, which will help improve the quality characteristics of the skin, and therefore achieve a better aesthetic result. The choice of a set of methods for the rehabilitation of such patients, according to the literature, is very wide, but despite the variety of methods, at present, there is no consensus on the optimal method of restorative therapy in patients who have undergone liposuction, which determined the relevance of this study.

Material and methods. We observed 29 patients aged 35 to 45 years. Patients were divided into groups: Group 1 – RF liposuction was performed, Group 2 – RF liposuction and Nd: YAG laser therapy.

Results of the study. The data of the comparative analysis of 2 variants of restorative treatment of local fat deposits of the shoulders revealed the high efficiency of radiofrequency liposuction, and also substantiated the appointment of laser therapy after liposuction, which contributed to the increase in efficiency in relation to obtaining the most acceptable aesthetic result.

This article describes the possibilities of TEKAR therapy. TEKAR therapy is an innovative technique used in physiotherapy and rehabilitation. Its scientific basis is based on the principles of electromagnetic energy transfer, which includes two main mechanisms: capacitive and resistive energy transfer. TEKAR therapy works by using radiofrequency energy, usually in the range of 300 kHz to 1.2 MHz. The article details the principles of operation and mechanisms of action of this therapy, provides a rationale for its effectiveness, and, in addition, discusses contraindications in detail.

Relevance. The problem of hair loss in men remains one of the most pressing in modern trichology and aesthetic medicine. Androgenetic alopecia (hereinafter AGA) is characterized by gradual thinning, thinning and further loss of hair in men in the frontal-parietal zone. Cosmetic defect of varying severity significantly affects the quality of life of patients, causing psychological discomfort and social maladjustment.

Objective. To evaluate the efficacy and safety of the manual hair transplantation (HFE) method for androgenetic alopecia in men, including an analysis of graft survival, cosmetic results and patient satisfaction in the short and long term.

Research results. This article evaluates the efficacy of the manual hair transplantation method HFE in comparison with others: Strip (FUT) and FUE Machine. The HFE (Hand Follicular Extraction) technique is a modern solution in the treatment of androgenetic alopecia in men. The peculiarity of the method is the most gentle extraction and transplantation of hair follicles without the use of automated systems, which ensures: high precision of manipulations, minimal trauma to surrounding tissues, minimal damage to the hair follicle, a natural result, and a shorter rehabilitation period. The HFE method allows the doctor to fully control the process of extraction and implantation of follicular units, taking into account the individual characteristics of the scalp and hair structure of each patient. This is important in AGA, when a delicate approach to depleted and weakened follicles is required.

On April 10, 2025, the Expert Consensus on the topic “Practical issues of using activated zinc pyrithione in dermatology” was held in Moscow. The issues of the role of external non-hormonal anti-inflammatory therapy in the management of patients with chronic dermatoses and the possibilities and feasibility of using activated zinc pyrithione in dermatology were discussed. The key aspects of the use of the topical drug Skin Cap in patients with seborrheic dermatitis, psoriasis, atopic dermatitis, steroid rosacea were identified and the main practical advantages of using the topical drug Skin Cap in the treatment algorithms for patients with chronic dermatoses were highlighted.

The article is an overview and contains up-to-date information on the mechanisms of androgenetic alopecia (AGA) pathogenesis, as well as various therapeutic methods aimed at its correction, using medication and physiotherapy techniques. AGA is a highly prevalent condition of hair loss regardless of gender, age and race, and has a significant impact on the quality of life of patients. Although there are many treatment options available to patients with AGA, the most common are the FDA-approved drugs minoxidil and finasteride, while data on the use of alternative treatments is limited. The use of fractional ablative and non-ablative lasers in combination with topical therapy is a promising method characterized by a high safety profile, tolerability and effectiveness.