Peri-implantitis is a common problem, leading to tissue destruction and implant loss. The method of treatment for peri-implantitis should be selected depending on the extent of the disease. The diverse physicochemical and targeting properties of nanodelivery systems provide a favorable platform for drug delivery for the treatment of peri-implantitis. The review presented herein analyzes domestic and foreign literature devoted to the issues of possibility and problems of application of laser phoresis and liposomal complex in the treatment of peri-implantitis patients. The analysis and systematization of available modern data on the application of laser technologies and liposomal complexes in periodontal treatment is carried out. The absence of clinical researches on this subject with the minimal level of studying the use of this technique in the treatment of periodontal pathologies is established, which determines the relevance of further researches in this direction in order to provide more effective rendering of dental implantation services.

   The purpose of this study was to analyze various literature sources, giving an exhaustive overview of the characteristics of all structural materials currently used in the manufacture of dental implants, which will also determine the trend of new developments in materials science in dental implantology.

   The research material included literary data presented in scientific publications indexed in the bibliographic databases PubMed, ScienceDirect and E-library, using the keywords isolated and their combinations in Russian and English « dental implants, titanium, zirconium, ceramics, tantalum, biocompatibility, osteointegration, graphene» as search terms. The results showed that the use of all existing materials and technological processes for the production of dental implants is justified. To date, the task of further scientific research in this field is to search for and/ or create a material that meets all the necessary operational requirements for a dental implant, has greater biocompatibility, less toxic effects on the body or its absence, providing optimal functional and aesthetic properties, at the lowest possible cost of manufacturing the product. Studies of ceramic-metal materials with the addition of graphene are promising, as currently studies show its high potential acceptability for integration in the development of new materials and technological processes for the production of dental implants.

   The issue of tooth strength loss due to hard tissue loss after endodontic treatment remains relevant. Intracanal pins and cores are widely used for long-term restoration of the anatomical and functional integrity of depulped teeth. Modern studies focus on the multifactorial nature of morphofunctional processes of restoration of lost tissues. The main parameters are the size of the restored crown, the shape of the root canal and the redistribution of occlusal loads. Physicochemical characteristics of pin materials are also important, such as: biocompatibility, strength, elasticity, hypoallergenicity, adhesion quality and aesthetics. Previously, preference was given to metal pins, but they have disadvantages: corrosion, weak connection and low aesthetics, which makes them less attractive compared to modern alternatives.

   In connection with the above, the purpose of this study is to develop a technology for the two-stage manufacture of graphene-containing dental pins using the 3D printing method.

   Materials and methods: The technology for manufacturing dental pins is based on the use of the method of printing monoceramic dental products. The process uses a zirconium suspension, which is a poorly soluble viscous white liquid with a specific odor, with which printing will occur. As part of the development of the technology for producing monoceramic dental products, a large number of dental pins were printed using an additive printer based on selective laser stereolithography. Then, the porous blanks will be pre-functionalized with a suspension of graphene oxide and sintered in vacuum conditions, and will be studied further. Thus, the introduction of 3D printing technology in the process of manufacturing dental pins will open up opportunities for the use of new promising domestic materials in clinical practice.

   Zirconium oxide (ZrO₂) occupies a significant place in the production of engineering materials due to its outstanding physicochemical stability. Advances in the stabilization of zirconium materials have opened up new horizons for their application, ranging from medicine to sophisticated aerospace technologies. Particular attention is paid to its role in CAD/CAM technologies in dentistry, which provide high precision and reduce treatment times.

   The aim of this study is to develop and optimize methods for the production and consolidation of nanostructured zirconium oxide powders for CAD/CAM applications.

   Materials and methods: High-quality zirconium oxide in the form of stabilized 3Y-TZP powder containing 3 mol. % yttrium oxide (Y2O₃), which provides stabilization in the tetragonal phase, was used for the study. In addition, various additives such as polyethylene glycol (PEG) and polyvinyl alcohol (PVA), which serve as binders and plasticizers, were used to improve the agglomeration and sintering processes. Of course, CAD/CAM technologies occupy one of the first places in modern dentistry. Research and optimization of the production process of domestic CAD/CAM blanks made of zirconium dioxide will help to improve production technologies and improve their characteristics. The main focus of the study was on improving mechanical properties, such as density, hardness and resistance to cracking, which are key to the functional reliability of the material. The development of domestic CAD/CAM blanks, whose characteristics are not inferior to foreign analogues, will improve the quality of dental services and will contribute to import substitution in this area. The study of properties and their subsequent optimization emphasize the significant potential of this area, contributing to further scientific research and technological innovations, creating a foundation for future technological breakthroughs.

   The article discusses the etiology, clinical picture, diagnosis and methods of treatment of retention cysts of the minor salivary glands using cutting instruments and a diode laser. Analysis of statistical data shows that retention cysts of the lower lip are the most common form among salivary gland cysts. In the process of surgical treatment of retention cysts using classical cutting instruments, a number of difficulties arise associated with the thin capsule covering the cyst, by breaking through and pouring out the contents, as a result of which complete removal of the cyst is impossible and the appearance of a possible relapse, swelling after such surgery can lead to complications of the nearby salivary glands. Therefore, in a comparative aspect, the effectiveness of laser thermal ablation and the use of adhesive balm (with magnetic polymers, hexethidine, cytylpyridinium chloride and hyaluronic acid) is shown. New possibilities in the treatment of this pathology with minimal risk of complications are presented.

   Relevance. In patients with orthodontic structures, plaque accumulating for a long time around a non-removable device can lead to enamel demineralization, rapidly progressing to a carious cavity and the development of gingival inflammation. An important aspect of the management of such patients is measures to reduce the risk of caries and improve the effectiveness of oral hygiene.

   The aim of the study was to assess the level of oral hygiene in patients undergoing orthodontic treatment in groups with different methods of enamel preparation before fixing braces.

   Materials and methods. A randomized, controlled trial was conducted involving 60 patients aged 18–30 years. To assess the level of oral hygiene and the intensity of caries, we determined: the DMF index, the index of oral hygiene of OHI-S. The assessment of the enamel condition after removal of braces was carried out using the Adhesive Remnant Index (ARI). Universal Bond adhesive system (Tokuyama Dental), SHIELD FORCE PLUS varnish (Tokuyama Dental), double-curing adhesive fixing cement ESTECEM PLUS (Tokuyama Dental) were used to fix the braces. The effectiveness of oral hygiene was evaluated before treatment and 12 months after the start of orthodontic treatment.

   Results. There was a statistically significant decrease in the index of ОНІ-S in patients with ceramic and metal braces, the enamel surface of which was treated with varnish. The index of ОНІ-S before the start of the study in patients with ceramic braces was 1.5 ± 0.12, with metal ones – 1.4 ± 0.47. After 12 months, the index values were 1.6 ± 0.36 and 1.5 ± 0.46, respectively, p = 0.002. In the group of patients whose surface was not treated with varnish, the index values were statistically not significant, p > 0.05. When assessing the resistance of teeth to the development of caries using the DMF index, a statistically significant difference was also found in groups where bracket systems were fixed with pretreatment of the enamel surface with varnish. The value of the DMF index before the start of the study in the group of patients with ceramic braces was 1.7 ± 0.22, in the group with metal braces – 1.4 ± 0.14. After 12 months, the index values were 1.8±0.16 and 1.5 ± 0.23, respectively, p = 0.0012.

   Conclusion. The use of varnish before fixing braces helps to improve the condition of the oral cavity, which is expressed in improved hygiene, as well as in the absence of pathological changes on the enamel surface in the form of demineralization. In this regard, further studies are needed to assess the degree of influence of varnishes on the condition of the oral cavity in patients undergoing orthodontic treatment.

   Relevance. The amount of data on the relationship between the oral microbiome, in particular the tongue, and systemic health is constantly growing, while the impact of various antibacterial agents on this ecosystem remains insufficient.

   Study objective: to evaluate the effectiveness of an antibacterial tongue foam containing cetylpyridinium chloride.

   Materials and methods. The study included 30 patients who were randomized into 3 groups comparable in terms of the initial tongue hygiene index. Group 1 used only a toothbrush and toothpaste without antiseptics for home care, group 2 additionally used a scraper, group 3 – a brush, hygienic paste, scraper and antibacterial foam. All three groups were compared based on the results of assessing the Ulitovsky tongue hygiene index at baseline and 14 days after the appointment of hygiene products. In groups 2 and 3, an additional microbiological study was conducted.

   Results. The study of the results of the index assessment of the hygienic condition of the tongue showed that statistically significant differences were obtained between the beginning of the study and its end in groups 2 and 3, while in group 3 the changes were more pronounced. And when comparing all three groups, reliable differences were obtained between the study groups. The microbiological study of groups 2 and 3 yielded statistically significant differences in the performance of the antibacterial foam in relation to the Enterobacteriaceae family, the Streptococcus family, the Gardnerella vaginalis + Prevotella bivia + microorganism group of the Porphyromonas family, the Peptostreptococcus family, the Candida family, namely, a decrease in their number, according to the quartile analysis.

   Conclusions. The use of antibacterial foam containing cetylpyridinium chloride in combination with the use of a tongue scraper significantly improves the hygienic condition of the tongue and the composition of the microflora.

   Primary chronic osteomyelitis of the jaw bones is a rare and poorly studied pathology in the maxilofacial region, which causes difficulties in diagnosis, differential diagnosis and treatment. In this regard, the purpose of this study was to identify significant diagnostic and differential diagnostic clinical and radiological criteria in patients with productive-destructive form of chronic osteomyelitis of the jaw bones.

   53 patients with chronic forms of osteomyelitis of the jaw bones were examined and treated. The main criteria that are important in the diagnosis of productive-destructive form of chronic osteomyelitis and comes as basis for planning comprehensive treatment were identified.

   Issues of diagnosis, treatment, and medical rehabilitation of post-Covid syndrome in the maxillofacial area require further research. Complications after a COVID infection, which mainly affects the respiratory system, are numerous. Factors that determine the development of complications in the maxillofacial area are the virus itself, which leads to a hypercoagulability, and the drugs used in treatment, especially corticosteroids. Also significant are concomitant diseases, especially diabetes. Patients with severe purulent-necrotic lesions of the bones of the facial skull come to maxillofacial clinics.

   During operations for the removal of tumors in the maxillofacial region, aesthetic facial defects and functional disorders are formed: disorders of speech, chewing, swallowing and breathing. Removal of the right eyeball and surrounding tissues after combined treatment of basal cell carcinoma of the right orbit led to the formation of a defect that disrupted the patient’s quality of life. Closing the defect by transplanting a combined flap does not make sense in this case. The manufacture of an ectoprosthesis without supporting elements, taking into account the formed anatomy, does not allow to achieve reliable fixation of the ectoprosthesis. The use of adhesive compositions for fixation in this area is extremely limited and rarely used. Rehabilitation of patients with extensive combined defects of the maxillofacial region is carried out using implant-prosthetic structures. A clinical case of ectoprosthetics of the right orbit is presented with a detailed discussion of all aspects of the design, prototyping and manufacture of the prosthesis.

   Orbital ectoprosthesis is a complex, multifunctional problem. Removal of the right eyeball and surrounding tissues after combined treatment of basal cell carcinoma of the right orbit led to the formation of a defect that disrupted the patient’s quality of life. The key factor for successful treatment is the area of proper placement of implants in the orbit, taking into account the anatomy of the left eye, deep sinking of the surrounding tissues. The rehabilitation of a patient with a defect in the right orbit was implemented using an implant-prosthetic design. At the stages of treatment, the tasks set were solved and original solutions were developed for the full restoration of aesthetics. A clinical case of ectoprosthetics of the right orbit, aspects of design, prototyping and manufacturing of the prosthesis are presented.

   Background. The widespread occurrence of mineral metabolism disorders in the modern world, including those due to vitamin D deficiency, affects the results of patient rehabilitation performed by dental surgeons using dental implants.

   The aim of the study was to assess the state of mineral metabolism during dental implantation in young and middle-aged patients with tooth loss due to vitamin D deficiency.

   Materials and methods. From 2011 to 2024, 450 patients aged 25–50 years with tooth loss due to identified vitamin D deficiency in the absence of other somatic pathology were examined and treated at Sechenov University and a private clinic. All patients underwent laboratory examination, including assessment of mineral metabolism indicators – the level of total calcium, vitamin D (25 (OH) D), parathyroid hormone, thyroid stimulating hormone. Also, 30 randomly selected patients underwent assessment of osteogenesis markers (bone matrix formation marker P1NP, serum cross-linked C-telopeptide of type I collagen CTX). Patients were referred to an endocrinologist due to detected vitamin D deficiency, therapy was prescribed. All patients underwent dental implantation and concomitant surgeries to increase bone volume, if necessary, considering the study group: in group 1 – until reference values of vitamin D were achieved, in group 2 – after. Comparison of parameters before and after drug therapy was performed using Student’s T-test or Mann-Whitney, the results were considered statistically significant at p < 0.05.

   Results. In the examined sample, 2.1 % of patients had a pronounced deficiency of (25(OH)D) (< 10 ng/ml), 60.4 % had a deficiency (< 20 ng/ml), and 37.5 % had insufficiency (20–30 ng/ml), with the initial level of vitamin D in both study groups not statistically different (< 20 ng/ml, p < 0.05). After the treatment, the level of (25(OH)D) in all patients reached the reference values (30–60 ng/ml, p < 0.05) also without statistically significant difference when compared by groups (median 1 = 42.75 and median 2 = 43.65, respectively, p > 0.05), but was significantly higher when assessed dynamically within each
group (p < 0.05). No deviations from reference values for osteogenesis markers were found over time, although a statistically significant slight decrease in both parameters within the normal range was noted after treatment compared to the initial level (p < 0.05).

   Conclusion. In young and middle-aged patients with tooth loss due to vitamin D deficiency, no significant changes in laboratory parameters (blood calcium levels, parathyroid hormone, and osteogenesis markers over time) were found during dental implantation and concomitant surgeries.

   Introduction. The operation of resection of the tip of the tooth root is one of the main dental–preserving surgical methods of dental treatment with destructive changes in periapical tissues. Despite the high efficiency and other positive aspects, there are some disadvantages of this method of treatment, among which one can single out a long period of healing of periapical tissues, which necessitates the search for remedies that contribute to solving this problem.

   The aim is to study the possibility of using a drug based on extracellular matrix biomimetics as a means of regenerative therapy during resection of the tip of the tooth root, to evaluate its effect on the healing time of periapical tissues and the occurrence of complications.

   Materials and methods. The study involved 42 patients with indications for resection of the tip of the tooth root. The patients were randomly divided into two equal groups (n = 21): the control group, which underwent a traditional operation of resection of the tip of the tooth root, and the study group, which additionally used a drug based on extracellular matrix biomimetics. The timing of complete healing of periapical tissues and the presence of complications (in the form of lack of healing) were assessed using targeted intraoral contact radiography and percussion 6 months after the operation. The collected data were statistically analyzed. The indicators of descriptive statistics included the number of objects, the average value, the mean square deviation (SKO), 95 % confidence interval (CI95 %), median, lower (Q1) and upper (Q3) quartiles, minimum and maximum values. The comparison of the healing time in the study and control groups was carried out using the nonparametric Mann – Whitney criterion for independent groups. The comparison of the groups by the number of complications was carried out using the exact Fisher criterion.

   Results. In the study group, healing occurred on average after 129.9 days. (COE = 8.6 days), DI95 % 126.0–133.8 days, minimum healing period – 117.0 days, maximum – 151.0 days, median – 128.0 days, lower and upper quartiles 124.0 days and 133.0 days accordingly. In the control group, the average healing time was 181.5 days. (COE = 9.0 days), DI95 % 177.4–185.6 days, minimum healing period – 167.0 days, maximum – 199.0 days, median – 181.0 days, lower quartile – 175.0, upper quartile – 188.0 days. A comparison of the groups by healing time using the nonparametric Mann – Whitney criterion for independent samples showed a statistically significant difference (p = 0.00000003). In the study group, healing was faster (on average 129.9 days) than in the control group (on average 181.5 days). A comparison of the groups by the proportion (%) of complications using the exact Fisher criterion showed that there was no statistically significant difference between the groups (p = 0.49). In the study group, healing was in 21 (100 %) patients, in the control group – in 19 (90.5 %), complications were in 2 (9.5 %) patients.

   Conclusion. The results obtained during the study indicate the effectiveness of using the drug based on extracellular matrix biomimetics after resection of the tip of the tooth root: its effect reduces the time for complete healing of periapical tissues and completely prevents the occurrence of complications in the form of lack of healing.

   The article presents the results of testing the herbal-based mouthwash «Art-Dentale Expert» for compliance with regulatory requirements, including safety analysis, packaging, and labeling.

   The study aimed to evaluate the mouthwash’s safety and consumer satisfaction through a questionnaire survey.

   Findings. The «Art-Dentale Expert» mouthwash complies with the standards TRCU 009/2011 «On the Safety of Perfumery and Cosmetic Products». A survey of 70 patients with mild chronic generalized periodontitis showed significant reductions in gum bleeding and good tolerability of the product. However, 34 % of respondents expressed dissatisfaction with the need to dilute solution the mouthwash before use.

   Conclusions. The product meets various regulatory standards, including requirements for appearance, pH, toxic element content, microbial safety, packaging, and labeling. It can be recommended for use in the comprehensive treatment of chronic generalized periodontitis. Positive attributes noted by respondents included taste (87.14 %), smell (63.16 %), a pleasant feeling after use (92.86 %), gum recovery (90 %), reduction in gum bleeding (100 %), tolerability (97.14 %), and rapid therapeutic effects (72.86 %). No adverse effects were reported, but the dilution requirement was a notable drawback for some users.

   In this mathematical experiment, a comparative study of microdeformations and von Mises equivalent stresses arising in the elements of two orthopedic bridge structures with different abutment shapes was conducted using the finite element method. The strength limits of both structures were also compared. The structures under study had the same external geometry and corresponded to two premolars and the first molar. The difference between the models under study was in the superstructures that are inserted and fixed in the implants and serve as a support for artificial crowns. The first model used flat superstructures (or flat abutments), while the second model used conical superstructures (or universal multi-units). The data obtained indicate the clinical significance of choosing the optimal abutment shape when planning surgical interventions and predicting subsequent patient treatment results.

   Topicality. The specialized literature does not sufficiently present the systematization of concomitant malformations additional to congenital cleft of the maxillofacial region, the frequency of their occurrence and the species correlativity of relationships. There is no program for concretizing the interaction of specialists in different fields that ensure the unity of the processes of diagnosis and rehabilitation of patients with complex disorders of embryogenesis.

   Purpose. To present the main directions of specialized care for children with congenital cleft of the maxillofacial region in combination with malformations of other organs and systems.

   Materials and methods. A group of patients (823 people) who received treatment at the Center «Bonum» (Yekaterinburg) for a period of 25 years (1998–2022) with cleft maxillofacial region and concomitant malformations was studied. In the course of the study, the data of malformations were systematized, and correlations between congenital concomitant defects were identified. Clinical and special methods of patient examination were used in the study.

   Results. An innovative methodology for systematic monitoring and treatment of patients with maxillofacial cleft in combination with concomitant malformations has been developed based on a staged algorithm of therapeutic and corrective interactions of rehabilitation specialists of various profiles. The optimal tactics of the interacting advantages of the treatment process of concomitant congenital malformations are presented, taking into account the sequence of rehabilitation measures, the volume and duration of surgical elimination of the cleft against the background of concomitant
anomalies.

   Conclusions. The proposed methodological algorithm for the dynamic observation of 823 patients with cleft of the maxillofacial region, complicated by malformations of other organs and systems, has absorbed the fundamental directions of therapeutic and corrective interactions of specialists in various fields, concentrating knowledge and experience on this issue for a period of 25 years (1998–2022) and made it possible to minimize postoperative complications (the indicator of residual deformities of the upper lip and nose after the primary cheilorhinoplasty amounted to 16,16 %, and after velourinoplasty – 2,46 %), to successfully complete (in 73,63 % of cases) the main stages of surgical treatment of the maxillofacial region, as well as the main processes of restoring the health of this group of patients in accordance with the age periods of rehabilitation.

   Objective. To establish the effect of biotribocorrosion on the development and chronic course of pseudomembranous candidiasis.

   Materials and methods. The study was conducted at the Department of Orthopedic Dentistry and Gnatology and at the Department of Propaedeutics of Orthopedic Dentistry of the Russian University of Medicine. The study involved 80 patients with pseudomembranous candidiasis using metal dentures and 40 patients with pseudomembranous candidiasis without metal-containing structures, who made up the control group. All participants in the study measured the difference in oral biopotentials, hydrogen index, and salivation rate.

   Results. In patients of the main group, the content of Fe, Cr, Ni, Ti, Si, K, Na in saliva was significantly increased (p < 0.05) compared with the control group. It was found that dissimilar metal alloys have different effects on the duration of use of dentures. In pseudomembranous candidiasis and the presence of metal-containing structures with signs of biotribocorrosion, a more pronounced electrochemical reaction of stainless steel coated with titanium nitride and uncoated significantly reduces the life of dentures (from 3 to 5 years), compared with CCC metal-ceramic prostheses (from 2 to 10 years) and Ni-Cr-Ni-Cr (from 5 to 8 years old). The greatest pH shift to the acidic side is observed with a combination of stainless steel and Ni-Cr prostheses (pH 5.5–6.0). In pseudomembranous candidiasis, patients using metal dentures have the highest potential differences between M-M.

   Conclusions. Due to tribocorrosion, corrosion products enter the oral fluid, under their influence, a decrease in pH occurs, provoking a weakening of the protective properties of saliva, a violation of metabolic processes and structural changes in the oral mucosa. Thus, there is a favorable environment for the growth of fungi of the genus Candida, inflammation of the oral mucosa occurs. Microbial flora and fungi that stimulate the development of the inflammatory process are localized in inflammatory areas.

   Relevance. New dental materials made of zirconium dioxide include 3Y-TSP and 5Y-TSP, suitable for various clinical cases, including multilayer systems that create a transparency gradient. After milling, the pre-sintered Y-TZP frames must be subjected to final sintering in 8–10 hours, although modern technologies can reduce it to 17 minutes. However, high-speed sintering can degrade the color and transparency of finished prostheses. The new monolithic ceramic systems have increased the Y3+ content to about 4 and 5 ml. %, but the indicators of layered transparency of multilayer samples after high-speed sintering remain insufficiently studied.

   The purpose of the work. The study of layered transparency after traditional and high-speed sintering of domestic multilayer ceramics made of zirconium dioxide and its imported analog using a laboratory
spectrophotometer.

   Materials and methods. Groups of 12 samples were studied: the main one (domestic production of «Ziceram ML ET») and the control one (Chinese production of «Aidite 3D Pro»), divided into subgroups «a» (traditional sintering) and «b» (high-speed sintering). The size of all samples is 15×15×1 mm, colors A1–A3, milled by removing plates from a single layer. Subgroups «a» were fired according to traditional modes with an exposure time of 30–120 minutes. Subgroup «b» was baked in a high-speed furnace in 25 minutes. Transparency was assessed using an X-Rite Ci4200 spectrophotometer using the CIE Lab* system, calculating the ratio of the «L» luminance indicators on a white and black background.

   Conclusions. The lightness of the layers of multilayer ceramic blanks «Ziceram ML ET» and «Aidite 3D Pro» is significantly reduced after high-speed sintering compared to traditional firing. The transparency gradients of Russian and Chinese multilayer ceramics differ, with significant changes after high-speed sintering.

   Relevance: to substantiate programs for the prevention of dental diseases at nuclear industry enterprises with dangerous working conditions, comparative studies of the dental status of employees, depending on the presence or absence of previous oral sanitation, are relevant.

   The purpose of the study: clinical and radiological comparison of indicators of the dental status of nuclear power plant workers with hazardous working conditions (OT), depending on the presence or absence of previous oral sanitation.

   Materials and methods: 78 employees of the Kalinin nuclear power plant with dangerous working conditions in the key age group of 35–44 years, who underwent therapeutic and surgical sanitation of the oral cavity a year ago, were examined. For comparison, 69 workers with OT of an identical gender and age group who refused to sanitize the oral cavity during periodic medical examinations were examined. The sequence of clinical and radiological examination corresponded to the modified WHO Dental Status Assessment Map (1995).

   Results: the positive effect of oral sanitation due to the removal of destroyed teeth, treatment of caries and its complications, as well as periodontal diseases is to reduce the prevalence of signs of dysfunction of the temporomandibular joint by 52.5 %, non-carious offspring 22.7 %, diseases of the oral mucosa 24.1 %, periodontal diseases 6.0 %. As a result of sanitation, the detection of poor oral hygiene is reduced by 54.7 %. The intensity of caries and periodontal diseases a year after sanitation is 12.8 and 27.8 % lower in comparison with workers with an unsanitized oral cavity. After rehabilitation, the prevalence of orthopedic treatment increases by 43.4 %.

   Conclusions: oral sanitation significantly improves the basic indicators of dental status for workers with dangerous working conditions at nuclear power plants. The positive effect of oral sanitation is largely preserved after a year in comparison with non-sanitized workers. Oral sanitation at the age of 35–44 years does not affect the prevalence of caries.

   In this work, samples for implantation surgery based on titanium and its alloys: VT6, VT6+Ti, VT6+TiO₂, VT6+ZrO₂ were studied for biocompatibility and angiogenesis in vivo on a model of chorioallantois membrane of a chicken embryo. As a result, quantitative and qualitative characteristics of the conducted studies were obtained, the most suitable conditions and materials for further use in implantation surgery were identified, estimates of the use of materials based on titanium and its alloys were given, and the biocompatibility of samples was summarized.