Itchy skin, a symptom of various diseases, present in 54.4 % of patients with skin pathologies, is a rather difficult task when choosing a therapy.

Material and methods. Under observation were 45 patients (27 women and 18 men) with various dermatoses, accompanied by itching. All patients received Neotanin therapy (cream and spray) with standard topical therapy. Efficiency assessment was carried out taking into account the indices Prurindex, BRS, dermatological status indices for each nosology (SCORAD, EASI, PASI), and DIC.

Results. In patients with idiopathic skin itching, Prurindex decreased by 100 % by the end of 3rd weeks, BRS – by 96.8 %. In atopic dermatitis, the SCORAD index decreased by 78.3 %, BRS index reduced by 91.9 %, Prurindex index decreased by 95.4 %. With eczema, the EASI index decreased by 96.1 %, the BRS and Prurindex index were reduced by 100 %. In psoriasis, the PASI index decreased by 86.5 %, BRS index – by 90.8 %, Prurindex index – by 94.2 %.

Conclusions. The use of the topical Neotanin as monotherapy for idiopathic pruritus, as a part of comprehensive treatment for atopic dermatitis, eczema, psoriasis, significantly improves the quality of life of patients.

Aim. A comprehensive review of peer-reviewed publications on placental drug (PD) therapy. The objectives of this review were to study the mechanisms of action of placenta preparations, as well as their effects in dermatology and cosmetology.

Materials and methods. A search was made in the databases PubMed, EuropePMC, Web of Science, Google Scholar for the keywords human placental extract, Laennec HPE and placenta. 3,957 publications were discovered for the period up to January 2020. After analysis, 3,878 publications were excluded due to data irrelevance.

Results. We have studied more than 3,957 publications on the topic of therapy with placenta drugs in various fields of medicine (taking into account literature reviews). A total of 47 representative original studies, clinical cases, and series of clinical observations were included in the review. Most studies were from Korea, India, and Japan.

Conclusion. Analysis results show that placenta preparations (Laennec et al.) can be used in various fields of medicine. The given clinical effects of placenta extracts are a consequence of the complex molecular composition of placental preparations. Over 4 thousand different proteins were found in the placenta, including growth factors, hormones, cytochromes, fibrinolysis factors, energy metabolism enzymes, estradiol, prostaglandins, enkephalins and other neuropeptides, a number of microelements (primarily significant amounts of organic zinc) were identified. A systematic analysis of the data shows that placenta preparations have established themselves as effective agents in the treatment of many pathologies. Nevertheless, one should not forget that there are contraindications to the use of PD, for example, pregnancy and lactation, childhood, allergic reactions to drugs and others. Therefore, such therapy is carried out only after consultation with specialists. In addition, further double-blind, randomized, placebo-controlled trials are needed to examine all the possible effects of placenta preparations.

Psoriasis is a chronic immunologically associated inflammatory skin disease associated with systemic concomitant diseases, including arthritis, cardiovascular disease, kidney disease, diabetes mellitus and metabolic syndrome. The evolution of ideas about the essence of this dermatosis has led to the concept of a “psoriatic march”: psoriasis as a chronic inflammatory disease is associated with a systemic pathological process. According to numerous epidemiological studies, up to 5–7 % of the world’s population suffer from psoriasis with a continuing increase in the incidence, including severe and torpid phenotypes that lead to the most able-bodied segments of the population becoming disabled. In recent years, the question arises more often of states comorbid to psoriasis. Dermatosis is often combined with cardiovascular diseases (CVD), mental disorders, immune-mediated diseases such as Crohn’s disease, lupus erythematosus. The main factor contributing to the formation of comorbidity in psoriasis is the commonality of some links in the pathogenesis of dermatosis and the listed diseases.

Representatives of the normal microflora of intestinal biota perform a physiologically important function of maintaining the constancy of the internal environment of the body, take part in the formation of the immunobiological reactivity of the macroorganism. Violation of normocenosis contributes to the chronicity of pathological processes (in particular, atopic dermatitis).

Material and methods. Under supervision were 36 patients with atopic dermatitis. Before treatment, 86.1 % of patients had persistent or intermittent clinical symptoms of dysbiosis. Depending on the treatment, patients were divided into 2 groups: group 1 (n = 19) received an external preparation with zinc pyrithione (Cinokap® cream / spray depending on the prevailing clinical picture), specialized dermatocosmetics. In addition to topical therapy, patients of group 2 (n = 17) received Lactofiltrum® 2 tablets 3 times a day for 14 days.

Results. After 4 weeks, the total index of the DIHS index decreased in the 1st group by 78.8 %, in the 2nd group by 85.8 %, BRS decreased in the 1st group by 89.2 %, in the 2nd group by 97.1 %. By the end of the course of therapy, DIC improved by 62.4 and 84.1 %, respectively.

Conclusions. The inclusion of the drug Lactofiltrum® in the treatment complex leads to a more rapid and pronounced regression of skin rashes and subjective sensations, normalization of the gastrointestinal tract, which contributes to a significant improvement in the quality of life. The drug has a favorable safety profile, convenient to use.

Psoriasis refers to genetically deterministic chronic inflammatory dermatoses, which are characterized by systemic immuno-mediated inflammatory response with preferential activation of the IL -23/-17 axis, growth deviation and keratinocyte differentiation.

Material and methods. There were 21 patients under supervision with moderate to severe plaque psoriasis. Nine (42.8 %) patients did not receive previous systemic therapy; 3 (14.2 %) patients received apremilast at a dose of 30 mg twice a day during a year, 4 (19.0 %) patients were prescribed methotrexate at a dose of 15 mg subcutaneously weekly, for at least a year; 5 (23.8 %) patients received secukinumab at 300 mg subcutaneously once every 4 weeks for a year. All patients had a lost of effect or had developed side effects, which determined a change in therapeutic tactics.

Results. Among the patients who were earlier not receiving treatment treatment after therapy with netakimab was started, the PASI index made 3.5 ± 1.1 (decrease by 94.4 %), the PASI index at the patients who were earlier receiving sekukinumab was 4.5 ± 1.1 (decrease by 81.9 %), among the patients who were earlier receiving the methotrexate the PASI index was 8.5 ± 1.3 (decrease by 89.9 %), at the patients who were earlier receiving apremilast the PASI index was 9.5 ± 2.1 (decrease by 86.3 %).

Conclusions. Improvement in skin symptoms was accompanied by improvement of patients’ quality of life. Thus, the DLQI decreased by 77.9 % in the group of patients who had not previously received systemic therapy, by 77.4 % and 76.4 % in patients who had previously received sekukinumab and methotrexate therapy, respectively, and by 85.2 % in the group of patients who had previously received apremilast.

The article presents a historical sketch of ‘the bloody biblical’ sweat. The data of world scientific literature were analyzed: the number of recorded cases, geography, age groups. We described clinical cases of hemohydrosis, i. e. a rare pathological phenomenon and dermatitis artificial. The base of the pathogenesis is diapedesis of erythrocyte in the skin without skin lesions. The pathologic condition is often caused by nervous tension. Differential diagnostics was carried out hematohidrosis and artistic dermatitis in girls of 10 years old. Artistic dermatitis was caused by makeup paints and imitated ecchymosisis. Both cases of the skin lesion were the result of the high level of the psychoemotional stress.

The main goal of this study was to assess the frequency of effectiveness and the tolerability of therapy in the treatment of severe acne with isotretinoin (Sotret) as monotherapy. In this study, 115 patients with severe acne were examined and treated: 107 (94.69 %) with papulo-pustular acne, 7 (6.19 %) with conglobate acne, and 1 (0.88 %) with keloid acne. Evaluation of the frequency of outcomes in the treatment of severe acne with isotretinoin Sotret was studied based on data obtained during a medical examination, which evaluated the dynamics of changes in the severity of acne according to the classification adopted by the American Academy of Dermatology (AAD, 1990) and based on data from the Assessment of Psychological and Social Effect of Acne (APSEA) Questionnaire.

The article provides an overview of the use of platelet-rich plasma (PRP) for the treatment of lichen sclerosis (LS). The definition, principle of operation and main characteristics of this method are given. Studies showing the effectiveness of PRP method were analyzed. Based on our research, we believe that PRP may be an alternative to treatment with topical corticosteroids. The method is a new treatment method for LS, which requires further randomized controlled trials.

Atrophic scars after acne are a widespread condition that can have a negative impact on the patient’s quality of life. Correction methods for acne scars include chemical peeling, dermabrasion, ablative or non-ablative laser resurfacing, filler insertion and surgical techniques. Depending on the type and severity of the scar, an individual approach is required to obtain satisfactory results.

Material and methods. Under observation were 61 patients with various manifestations of post-acne. Among them 21 (34.44 %) men and 40 (65.57 %) women. Depending on the therapy, the patients were divided into two groups and two subgroups depending on the type of scar. Efficiency was evaluated using ultrasound scanning.

Results. The RF microneedle method and fractional photothermolysis have a positive effect on the epidermo-dermal structure of the skin, which is expressed in the approximation of the acoustic density and thickness of the epidermis and dermis to normal values. The most pronounced positive effect in both methods was noted in the correction of post-acne hypertrophic scars. When analyzing the results of correction of atrophic scars, more pronounced positive dynamics was observed after the use of RF microneedles.

Alopecia areata (OA) is the most common cause of hair loss, occurring in approximately 4.5 million people. The incidence of OA in the structure of dermatological diseases is approximately 2.1 %. Promising in terms of the treatment of alopecia is low-intensity laser therapy and cell technology.

Material and methods. The clinical study involved 98 patients with a verified diagnosis of focal alopecia (OA). Among them, 53 (53.9 %) women and 45 (46.1 %) men aged 18 to 52 years. Patients received combination therapy, including laser plasma therapy for lesions and percutaneous laser irradiation of blood.

Results. The use of combined laser therapy in patients with focal alopecia promotes the relief of inflammation in the foci, the growth of core hair and the restoration of trace elements, according to dermatoscopy, phototrichogram and biochemical studies of hair composition.

The article presents current data on etiology and pathogenesis rosacea, listed endogenous and exogenous provoking factors. The pathogenetic justification given of the use of botulinum toxin type A in erythematosus-teleangiectatic subtype rosacea. A study involving 32 patients with ETP was carried out, during which a combination treatment was used – a course of microcurrent therapy followed by botulinum therapy by mesotechnics (in two different breedings). According to the results of the study, a pronounced clinical effect was established in patients. The results were evaluated using an analog VAS scale as well as DIQL. We came to conclusions about the effectiveness of combined use of microcurrent therapy and botulinum therapy in erythematosus-teleangiectatic subtype rosacea and the feasibility of further study of this issue.

This article provides information about the combined method of conservative treatment of venous trophic ulcers, using phototherapy with polychromatic polarized radiation and pulsed induction magnetotherapy in addition to the standard treatment. The article presents a clinical study of the effectiveness of this method in a group of 14 patients with venous trophic ulcers.

Objective. To evaluate the incidence of onychomycosis and bacterial contamination of onychopathy in patients with psoriasis.

Material and methods. The study included 86 patients with skin psoriasis and abnormal nail plates or isolated nail psoriasis. Patients nail plates examined in laboratory using direct microscopy with 20 % KOH, mycological culture Sabourauds Dextrose Agar with chloramphenicol and сycloheximide, and bacteriological culture with indetification using the MALDI-TOF mass spectrometer.

Results. Out of 86 patients, 27 (31.4 %) had onychomycosis (KOH-positive or KOH-negative with a positive result for dermatophytes in a culture study). Of the 27 patients with onychomycosis, 9 caused by pathogenic fungi, and 18 caused by opportunistic fungi. Of the 54 patients with nail psoriasis, 9 (16.7 %) had onychomycosis, 3 had dermatophytes, and 6 had opportunistic micromycetes. A total of 97 microbiological studies were conducted in 86 patients, in which the following microorganisms were detected: Staphylococcus caprae – 28 strains, Staphylococcus lugdunensis – 26, Staphylococcus epidermidis – 26, Staphylococcus haemolyticus – 15, Staphylococcus pettenkoferi – 13, Staphylococcus simulans – 11, Staphylococcus warneri – 8, Staphylococcus aureus – 5, Staphylococcus piscifermentans – 4, corinebacteria spp. – 3, Staphylococcus hominis – 3, Staphylococcus capitis – 3, Pseudomonas aeruginosa – 3, Staphylococcus pasteuri – 1, Staphylococcus cohnii – 1, Kocuria spp. – 1, Klebsiella pneumonia – 1.

Conclusion. In our study, onychomycosis was detected in 31.4 % of patients with psoriasis who have onychodystrophy. In psoriatic onychia, onychomycosis occurred in 16.7 % cases. Pseudomonas nail infection was observed in two patients, one in combination with nail psoriasis.

Regular follow-up is the most important preventive measure in patients with high risk for the development of melanoma. Particular attention is required for patients with dysplastic nevus syndrome, in which numerous lesions must be differentiated from malignant melanoma. General principles of monitoring of clinically atypical melanocytic lesions with the use of dermoscopy and indications for a diagnostic biopsy are discussed in the article.

Introduction. BCR-ABL tyrosine kinase inhibitors are currently used to successfully treat chronic myeloid leukemia (CML). Drug therapy is carried out in a continuous daily mode throughout the patient’s life. Treatment with this group of drugs is associated with specific dermatological adverse events (dAE), which can lead to a change in the regimen of effective, vital therapy for CML patients.

Purpose. To study the characteristics of dermatological adverse events, the severity and influence on the quality of life of BCR-ABL tyrosine kinase inhibitors.

Patients and methods. The observational study included 93 patients. The clinical manifestations of dAE, their severity were evaluated, their photographs and pathomorphological studies of skin biopsy samples were performed, cases of dose reduction or drug withdrawal due to dAE were recorded. The quality of life of patients with dAE was determined based on the assessment of the dermatological index of quality of life.

Results. Imatinib therapy was accompanied by a maculopapular rash in 43.3 % of patients, nilotinib caused follicular keratosis in 12.9 % of patients. In 3.2 % of patients, dasatinib caused hyperpigmentation, in 2.2 % of patients lichenoid rashes of the II degree occurred during treatment with bosutinib. Ponatinib treatment was followed by dAE in 9.7 % of patients. All dAE have an impact on the quality of life of patients, but the maculopapular rash and dyskeratotic changes are most pronounced. In a pathomorphological study, these dAE have specific features corresponding to immuno-mediated dermatitis.

Conclusions. The most frequent and pronounced dAE that significantly affect the quality of life of patients with CML are a maculopapular rash and dyskeratotic skin changes: psoriasiform and lichenoid dermatitis. Clinical and pathomorphological characteristics of skin reactions make it possible in the future to determine effective methods of supportive therapy for dAE.

Despite the existence of many algorithms for automated diagnosis of melanoma and other skin cancers, these remain almost inaccessible to public health service. A small number of publications on the efficacy of existing artificial intelligence systems marks the problems of their implementation into current examination routines in dermatology and oncology. New algorithms and software solutions as well as studies demonstrating their diagnostic accuracy on compatible and verifiable clinical material are still in demand.

Along with the increasing number of injection cosmetic procedures using various excipients, the number of complications also increases. The purpose of this review is to describe the most common adverse events associated with filler injections, as well as to identify the main preventive and therapeutic strategies. The review is of interest to practicing cosmetologists, dermatologists and plastic surgeons.

Besnier-Boeck-Schaumann sarcoidosis is a multisystemic disease of unknown etiology. Only about 25 % of patients have cutaneous involvement. Every patient with cutaneous sarcoidosis should be evaluated for possible systemic sarcoidosis. This article contains descriptions and original images of clinical forms of the disease: miliary sarcoidosis, circinate sarcoidosis, nodular sarcoidosis, angiolupoid (Brocq-Potrier), lupus pernio (Besnier-Tennesson), erythema nodosum, subcutaneous sarcoidosis (Darier-Roussy). Differential diagnosis and treatment of patients are discussed.

Porokeratosis is a rare disease with an autosomal dominant type of inheritance. It is customary to distinguish classic Mibelli porokeratosis, as well as disseminated and localized variations of the course of dermatosis, which differ in genetic predisposition, trigger factors, and treatment approaches. The article describes the variants of the disease – eruptive itchy papular malformation that occurs on the extremities against the background of microcirculation disorders and giant, developed on the skin of the trunk. The main methods of treatment of porokeratosis are also described.