In the International Classification of Diseases (ICD‑10), the diagnosis of chronic pain is not presented, which makes it difficult to conduct accurate epidemiological studies and prevents the development of an adequate diagnosis and multimodal therapy strategy. ICD‑11 will be the first version to include chronic pain as a diagnosis. According to the new concept, chronic pain is a real disease associated with multiple changes in the nervous, endocrine and immune systems. Developing a comprehensive treatment plan is of paramount importance and requires a multimodal plan that includes non‑drug and pharmacotherapeutic strategies for pain management. One of the promising areas of pharmacotherapy is the use of complex therapy regimens: meloxicam (Amelotex) – tolperisone (Calmirex) – B vitamins (compliments B).

The article focuses on the basic principles of diagnosis and treatment of migraine at the stage of primary health care. The diagnostic criteria of migraine, common diagnostic errors and alarming symptoms that are indications for instrumental investigations are given. The main treatment strategies of migraine are described: behavioral therapy, attack relief, and preventive therapy. Special attention is being paid to the treatment of a migraine attack, depending on its severity, including the features of the use of simple analgesics and triptans – specific drugs that have a pathogenetic antimigrenous effect. The principles of the use of tryptans that provide a high effect of relieving a migraine attack are being listed. The advantages of eletriptan as a last‑generation triptan, which is highly effective in relieving migraine attacks and is safer than other drugs in this class, are highlighted. Among the modern classes of drugs that have an evidence base in migraine prevention, those that can be successfully used by general practitioners are indicated.

The novel coronavirus (SARS‑CoV‑2) infection manifested by a pandemic and has a wide range of complications, including the nervous system’s complications. Despite the fact that older people with comorbidities are more at risk of developing complications from the sequelae of previous COVID‑19 disease, a significant link between the novel coronavirus infection and cerebrovascular disorders in young and middle‑aged people is increasingly mentioned in the literature. The development of cerebrovascular complications in these people not only depends on the damaging effect of the novel coronavirus infection on the macroorganism, but also on a number of other factors, in particular, on the genetic factors of the blood coagulation system. Further study of the possible influence the novel coronavirus infection on the development of cerebrovascular complications, taking into account the genetic factors of the blood coagulation system in young and middle‑aged people will provide early prevention and timely correction of cerebrovascular disorders.

Huntington's disease (HD) is a steadily progressive neurodegenerative disease caused by a mutation in the huntingtin gene, with progressive motor, cognitive and mental impairments.

The aim of the study is to determine the validity of the North‑East Visual Hallucinations Interview (NEVHI) in a Russian sample of patients.

Materials and methods. 78 subjects were examined: 26 patients at the manifest stage of HD, 21 pre‑manifest carriers of the HD gene and 31 volunteers of the control group.

Results. The low incidence of visual hallucinations according to the NEVHI does not allow us to conclude about their specificity for HD. Failure to achieve the level of statistical significance in this case suggests a high risk of type II error associated with the low occurrence of the symptom and the relatively small group size.

Conclusion. The study showed that the NEVHI questionnaire can serve as an adequate method for the diagnosis of visual hallucinations in HD.

The article presents the review of Russian and foreign literature, with the aim to summarize the results of the researches for the purpose of identification of the most perspective modern techniques of non‑invasive measurement of intracranial pressure. The methods of assessment of intracranial pressure based on morphological and functional features of intracranial organs are described: transcranial Doppler imaging, evaluation of tympanic membrane displacement, evaluation of blood pressure in retinal veins, evaluation of optic nerve diameter, CT imaging and magnetic resonance tomography. The attention is paid to merits and demerits of the presented methods, a possibility of their use in clinical practice.

Central and peripheral neurological pathology, which affects the thermal pattern and thermoreactions of the hands, is diverse both in etiology and pathogenesis, and in the nature and severity of thermal imaging signs, depending on the localization, severity and duration of the disease, individual adaptive and compensatory features, and a number of other reasons. The variants of the temperature distribution on the surface of the hands and its changes under the influence of specialized functional tests in injuries and diseases of the peripheral nerves of the upper limb, as well as in disorders of segmental and suprasegmental genesis, studied with the help of thermal imaging, are the subject of this article.