Cardiovascular diseases are socially imporfanf. A major role in fheir pafhogenesis is assigned fo risk facfors, inflammation and heredifary predisposifion. Associafions of polymorphisms of fhe genes AROA1, APOE, ACE, REN, AGT, AGTR 1, AGTR 2, BDKRB 2, MTHFR, ADRB 2, IRS, IL-10 and TNF-a wifh cardiovascular diseases risk facfors: obesify, diabefes melifus, dyslipidemia, have been sfudied. The associafion of fhe genes of fhe inflammafory sysfem wifh risk facfors also has been sfudied. The resulfs of fhe sfudy revealed a cross-associafion of gene polymorphisms wifh risk facfors, as well as fhe inferrelafion of all risk facfors wifh fhe genes of fhe inflammafory sysfem.

The article presents the latest recommendations of the American Heart Association (AHA), the American College of Cardiology (ACC) and the recommendations of the European Society for Hypertension (ESH) and the European Society of Cardiology (ESC) 2013 on the treatment of hypertension. The analysis of Pythagoras studies 2-4 on the frequency of the usage and the efficiency of monotherapy and the use of various groups of antihypertensive drugs in Russia has been carried out. The results of clinical studies of the effectiveness of calcium antagonists have been reviewed. Particular attention has been paid to a representative of calcium channel blockers of the third generation - the original amlodipine (Norvasc).

Individual choice of antihypertensive therapy depends on gender characteristics of patients. The article discusses the use of triple fixed combination of antihypertensive drugs amlodipine/ indapamide/perindopril in individually selected doses in hypertensive patients of high and very high risk. The effectiveness of the fixed combination, depending on the gender of the patients, was analyzed.

24-hour variability and the parameters of blood pressure (BP) circadian rhythm, i.e. the lack of BP decrease during nocturnal hours are independent risk factors for cardiovascular adverse events. Artificial light at night (ALAN) disrupts biological clock and predisposes to the development of complex metabolic disorders. Nevertheless, the role of the physical activity and sleep on the structure of variability and parameters of the circadian blood pressure rhythm and its ultradian variability studied yet fragmentally and the research on the effect of ALAN on blood pressure is even scarcer. In this paper, we present the results of a comparative study of the role of activity, sleep and ambient light on the circadian rhythm of blood pressure. We show that ALAN not only serves as a factor of sleep disturbance, but also has an effect on blood pressure. In addition, the response of physiological parameters to light is gender-dependent. In women, the reaction of blood pressure (elevation) and body temperature (delay of decrease) on the ambient light is more pronounced. We also assessed the physiological effect of melatonin on the background of exposure to ALAN. Sleep is necessary to reduce diastolic BP and heart rate; melatonin alone is not able to reduce diastolic BP and heart rate while maintaining the effect of light, at least, with a single dosage. At the same time, 1.5 mg melatonin reduces the systolic BP for 1.5-3.5 hours. This effect is not associated with the sleep and can subsequently contribute to a decrease in blood pressure in the morning.

Purpose. The present study explores albuminuria levels and its correlations with blood pressure (BP), uric acid level, and glomerular filtration rate (GFR) in randomized representatives of Krasnoyarsk Krai population. Methods. 66 people aged 31-69 were included in the study. 11 (16.7 %) of them were males and 55 (83.3 %) were females. All study participants completed the questionnaire and underwent anthropometry, routine blood and urine analyses. Additional laboratory analysis included blood uric acid, glucose, and creatinine (with Jaffe kinetic method) levels assessment along with im-munoturbidimetric albuminuria test. In case of the indications present, the renal ultrasound scanning was performed. The results of statistical calculations performed with IBM SPSS v.22 and StatSoft Statistica v.10 were considered significant at p ≤ 0.01. Results. 35 (53 %) of the study participants appeared hypertensive. 2 (3 %) people had diabetes mellitus, and they were hypertensive too. In 18 (27.23 %) people, the uric acid level was elevated. Albuminuria had the strong direct correlation (p ≤ 0.001) with both systolic and diastolic BP levels. The reverse correlation (p < 0.001) was present between GFR and BP levels. However, the reverse correlation between GFR and uric acid level appeared weak (p = 0.014). Conclusion. The present study elucidated the strong direct correlation between albuminuria and BP levels along with the reverse correlation between GFR and BP levels. Both correlations were applicable for either hypertensive and normotensive people. The correlation between GFR and uric acid level appeared weak.

Most patients have psychological stress in the preoperative period. The consequence of exposure to stress is an increased risk of complications in the perioperative period. Due to the individual characteristics, resistance to stress in patients is different. The purpose of the study was to identify gender differences in stress resistance. The study of test data and the level of stress hormone cortisol revealed a lower stress resistance to psychological preoperative stress in women.

Purpose. To determine the frequency of early vascular aging syndrome (EVA- syndrome) occurrence in young and middle age patients with hypertension and coronary artery disease (CAD). Materials and methods. The study involved 59 young and middle age (52 [46.5; 55.0], years) patients (men) with hypertension level of 1-3 in combination with stable angina pectoris 1^tt-3^rd class. The anamnestic data, results of coronary angiography, metabolic parameters, ultrasound of the heart and brachiocephalic arteries, relative telomere length, direct and indirect indices of vascular wall stiffness were evaluated. Results. EVA-syndrome was detected in 43 (72.9 %) patients with hypertension in combination with CAD. Patients were divided into subgroups depending on EVA-syndrome presence or absence. Two independent statistically significant predictors of EVA-syndrome - cardio-ankle vascular index (CAVI) (p = 0.011) and shortened telomeres (p = 0.035) were revealed. Increase of CAVI by one unit increases the EVA-syndrome chances of at 5.09 [1.78; 24.37] times, compared with patients with median values of all predictors included in the optimal model. The presence of shortened telomeres increases the chances of EVA-syndrome at60.69 [3.31; 8481.46] times. Conclusion. Independent predictors of EVA-syndrome in young and middle age patients with hypertension and CAD as CAVI and the shortened telomeres presence are revealed, the latter increase the probability syndrome presence.

Resistant hypertension (RH) can be defined as arterial hypertension not controlled by the use of three antihypertensive medicines (one being a diuretic) at optimal doses provided changed lifestyle. The present review summarizes the modern approaches to RH classification, diagnostic algorithm, differential diagnoses, and treatment. Special attention is paid to ambulatory blood pressure monitoring as essential tool for distinguishing specific hypertension types and pseudoresistance verification. Both traditional and new options of medicinal and interventional therapies are presented. Controversial issues of interventional techniques for RH correction are also discussed.

In troduction. Patients who had coronary artery bypass surgery are at high risk for shunt thrombosis. Objective of the study is to determine the role of hypertension in combination with other factors in causing the state of thrombotic preparedness in patients who had coronary artery bypass surgery. Materials and methods. 69 patients suffering from arterial hypertension and atherosclerotic cardiovascular disease who had coronary artery bypass surgery were examined. All patients underwent a study of the content of fibrinogen, von Willebrand factor, induced platelet aggregation and lupus anticoagulant in the blood on the 12th day after the surgery. Results. It was detected that long-term increase in arterial blood pressure, degree of increase in diastolic blood pressure and smoking caused the progression of state of thrombotic preparedness. The detection of circulating lupus anticoagulant after coronary artery bypass surgery did not depend on long-term increase in arterial blood pressure and its degree, but it was connected with myocardial infarction which patiens had previously. The degree of arterial sclerotic disease of coronary artery in patients suffering from arterial hypertension correlated with long-term increase in arierial blood pressure. Conclusion. Long-standing history of arterial hypertension and high diastolic blood pressure can cause the state of thrombotic preparedness at the early postoperative period after coronary artery bypass surgery.

Arterial hypertension is one of the most common diseases in the world. Among the factors influencing the risk of developing arterial hypertension and its complications, the stress effect is singled out. The study investigated the effect of prolonged psychological stress in mothers of children with cancer, on daily monitoring of blood pressure and cortisol levels. The results of the study revealed a rise in the level of anxiety and depression, an increase in the level of cortisol, a direct correlation between the level of pulse blood pressure and the duration of stress in women exposed to prolonged stress. The results of the study suggest that the effect of prolonged psychoemotional stress affects the mechanisms of development of arterial hypertension.

During the analysis of randomly selected 1,000 ambulatory cards of patients with arterial hypertension, consisting of dispensary observation in the Tyumen region, the features of antihypertensive therapy in the Tyumen region were assessed. It has been shown that RAAS blockers (97.2 %), diuretics (70.1 %) and BAB (69.2 %) are prescribed most often in the out-patient-polyclinic stage of medical care for AH patients in the Tyumen region. CCB and central action drugs are recommended for regular admission in 45.1 and 12.6 % of cases, respectively. The frequency of recommendation of fixed combinations of AHP (23.0 %), as well as statins for primary prevention of cardiovascular complications, is unjustifiably low.