Experience with Netakimab and a GLP-1 agonist in patients with psoriasis and metabolic syndrome
https://doi.org/10.33667/2078-5631-2026-3-28-34
Abstract
Understanding the pathogenetic relationship between psoriasis and obesity is crucial, as excess weight can reduce the effectiveness of medications, highlighting its clinical significance not only in the context of disease severity but also in relation to therapeutic outcomes, including with the use of genetically engineered biological therapies. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a class of drugs that act on incretin hormone pathways, normalizing metabolic disorders. Clinical trials have been published on the use of GLP-1 agonists in patients with psoriasis. In this context, studying the combined use of genetically engineered drugs and GLP-1 agonists in patients with psoriasis and associated metabolic syndrome is relevant.
Material and methods. Twelve patients with psoriasis and metabolic syndrome were observed. All patients were prescribed netakimab 120 mg and tirzepatide according to the package insert.
Results. The PASI index (PASI) scores were statistically significant (p<0.001) from pre-treatment to week 26, reaching PASI 90 and 100 in all patients, indicating a significant clinical response to therapy. In the study group, the median weight loss was 14 kg (95% CI: 12.00–15.00), with a minimum weight loss of 10 kg and a maximum of 15 kg. The average percentage weight loss was 13.02±1.23.
Conclusions. A comprehensive approach to treating patients with severe psoriasis and associated metabolic syndrome with significant excess body weight is the most appropriate strategy, as this category of patients is at risk of an insufficient response to genetically engineered drugs. This observational study demonstrated the high efficacy and safety of a genetically engineered IL-17A blocker (netakimab) and tirzepatide.
About the Authors
L. S. Kruglova
Central State Medical Academy of the Administrative Department of the President of the Russian Federation
Russian Federation
Russian Federation
Kruglova Larisa S., Dr Med Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, rector
Moscow
A. S. Bridan-Rostovskaya
Central State Medical Academy of the Administrative Department of the President of the Russian Federation
Russian Federation
Russian Federation
Bridan-Rostovskaya Anna S., postgraduate student at Dept of Dermatovenereology and Cosmetology
Moscow
E. A. Shatokhina
Central State Medical Academy of the Administrative Department of the President of the Russian Federation ; Medical Scientific and Educational Institute of the Lomonosov Moscow State University
Russian Federation
Russian Federation
Shatokhina Evgeniya A., Dr Med Sci (habil.), professor at Dept of Dermatovenereology and Cosmetology, professor at Dept of Multidisciplinary Clinical Training, leading researcher at Dept of Internal Medicine
Moscow
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For citations:
Kruglova L.S., Bridan-Rostovskaya A.S., Shatokhina E.A. Experience with Netakimab and a GLP-1 agonist in patients with psoriasis and metabolic syndrome. Medical alphabet. 2026;(3):28-34. (In Russ.) https://doi.org/10.33667/2078-5631-2026-3-28-34
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