Skin regeneration with plasma: a review of current concepts on technology, mechanisms of action, and clinical efficacy (literature review)
https://doi.org/10.33667/2078-5631-2026-3-23-26
Abstract
Plasma-assisted skin regeneration (PSR) is a modern non-ablative hardware-assisted rejuvenation technology based on the controlled thermal action of ionized gas (plasma). This review systematizes the fundamental physical principles of the method, in particular, the key differences between the two main types of plasma used – nitrogen (N2) and helium (He), which determine the features of their mechanism of action. The unique histological changes induced by PSR are considered in detail – the formation of the zone of thermal damage (ZTD) and the zone of thermal modification (ZTM), which underlie the pathogenesis of subsequent re-epithelialization and neocollagenesis. Data on the dynamics of tissue regeneration and the main clinical effects are presented, including the «biological dressing» effect, improved skin texture, and lifting. Comparative data of PSR with an ablative CO2 laser are presented, and the clinical indications for each technology are determined. The article discusses the indications for the use of PSR, its safety profile, possible complications, and contraindications. It is concluded that PSR occupies an important place in the arsenal of aesthetic medicine as a method that provides a predictable rejuvenating effect with a relatively short recovery period and a high level of safety for various skin phototypes.
About the Authors
O. S. Sodel
Skin Lift Clinic
Russian Federation
Russian Federation
Sodel Olga S., cosmetologist, chief physician of the Clinic
Moscow
I. A. Akhmedbaeva
Central State Medical Academy of the Administrative Department of the President of Russian Federation
Russian Federation
Russian Federation
Akhmedbaeva Inga A., PhD Med Sc, associate professor at Dept of Dermatovenereology and Cosmetology
Moscow
N. V. Gryazeva
Central State Medical Academy of the Administrative Department of the President of Russian Federation
Russian Federation
Russian Federation
Gryazeva Natalya V., Dr Med Sci (habil.), professor at Dept of Dermatovenereology and Cosmetology
Moscow
References
1. Foster K.W., Moy R.L., Fincher E.F. Advances in plasma skin regeneration / K.W. Foster, R.L. Moy, E.F. Fincher // Journal of Cosmetic Dermatology. 2008. Vol. 7, iss. 3. P. 169–179.
2. Bentkover S.H. Plasma skin resurfacing: Personal experience and long-term results / S.H. Bentkover // Facial Plastic Surgery Clinics of North America. 2012. Vol. 20, iss. 2. P. 145–162.
3. Kilmer S., Semchyshyn N., Shah G., Fitzpatrick R. A pilot study on the use of a plasma skin regeneration device (Portrait PSR3) in full facial rejuvenation procedures / S. Kilmer, N. Semchyshyn, G. Shah, R. Fitzpatrick // Lasers in Medical Science. 2007. Vol. 22, iss. 2. P. 101–109.
4. Elsaie M.L., Kammer J.N. Evaluation of plasma skin regeneration technology for cutaneous remodeling / M.L. Elsaie, J.N. Kammer // Journal of Cosmetic Dermatology. 2008. Vol. 7, iss. 4. P. 309–311.
5. Bogle M.A., Arndt K.A., Dover J.S. Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation / M.A. Bogle, K.A. Arndt, J.S. Dover // Archives of Dermatology. 2007. Vol. 143, iss. 2. P. 168–174.
6. Holcomb J.D., Schucker A. Helium Plasma Skin Regeneration: Evaluation of Skin Tissue Effects in a Porcine Model and Comparison to Nitrogen Plasma Skin Regeneration / J.D. Holcomb, A. Schucker // Lasers in Surgery and Medicine. 2020. Vol. 52, iss. 1. P. 23–32.
7. Current J.D. Physics Related to Anesthesia: учебник / J.D. Current; ред. J.D. Current. 2nd ed. 1999. Гл. 3: Vaporization [Heat Capacity]. С. [указать страницы].
8. Fitzpatrick R., Bernstein E.F., Harris D.M., Kilmer S.M. A Histopathologic Evaluation of the Plasma Skin Regeneration System (PSR) Versus a Standard Carbon Dioxide Resurfacing Laser in an Animal Model / R. Fitzpatrick, E.F. Bernstein, D.M. Harris, S.M. Kilmer // Lasers in Surgery and Medicine. 2008. Vol. 40, iss. 2. P. 93–99.
9. Lee R.C. Tissue injury from exposure to power frequency electrical fields / R.C. Lee // Advances in Electromagnetic Fields in Living Systems / ed. by J.C. Lin. Plenum Press, 1994. Т. 1. С. 81–127.
10. Olhoffer I.H., Leffell D.J. Bipolar radiofrequency for facial rejuvenation / I.H. Olhoffer, D.J. Leffell // Aesthetic Dermatology and Cosmetic Surgery. 1999. Vol. 1, iss. 1. P. 31–33.
11. Pedroso J.D., Pedroso A.C. D., Nahas S.C., Ribeiro U.R. Thermal effect of J-Plasma in a porcine tissue model: Implications for minimally invasive surgery / J.D. Pedroso, A. C.D. Pedroso, S.C. Nahas, U.R. Ribeiro // Surgical Technology International. 2017. Vol. 30. P. 19–24.
12. Flint M.H., Lyons M.F. The effect of heating and denaturation on the staining of collagen by the Masson trichome procedure / M.H. Flint, M.F. Lyons // Histochemical Journal. 1975. Vol. 7, iss. 6. P. 547–555.
13. Potter M.J., Harrison D.M., Bennett R.G. Facial acne and fine lines: Transforming patient outcomes with plasma skin regeneration / M.J. Potter, D.M. Harrison, R.G. Bennett // Annals of Plastic Surgery. 2007. Vol. 58, iss. 6. P. 608–613.
14. Theppornpitak N., Kamanamool C., Udompatikul P., Srisawat M. Nitrogen plasma skin regeneration for the treatment of mild-to-moderate peri-orbital wrinkles / N. Theppornpitak, C. Kamanamool, P. Udompatikul, M. Srisawat // Journal of Cosmetic Dermatology. 2019. Vol. 18, iss. 1. P. 163–168.
15. Holcomb J.D. Nitrogen plasma skin regeneration and aesthetic facial surgery: Multicenter evaluation of concurrent treatment / J.D. Holcomb // Archives of Facial Plastic Surgery. 2009. Vol. 11, iss. 3. P. 184–193.
16. Kono T., Chan A.R., Groff H.H., Yamaki T. Treatment of traumatic scars using plasma skin regeneration (PSR) system / T. Kono, A.R. Chan, H.H. Groff, T. Yamaki // Lasers in Surgery and Medicine. 2009. Vol. 41, iss. 2. P. 128–130.
17. Ross E.V., McKinlay J. R., Anderson R.R. Comparison of carbon dioxide laser, erbium: YAG laser, dermabrasion, and dermatome: a study of thermal damage, wound contraction, and wound healing in a live pig model: implications for skin resurfacing / E.V. Ross, J.R. McKinlay, R.R. Anderson // Archives of Dermatology. 1999. Vol. 135, iss. 4. P. 444–454.
18. Avram M.M., Tope T.S. H., Yu T., Dover J.S., Anderson R.R. Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing / M.M. Avram, T. S.H. Tope, T. Yu, J.S. Dover, R.R. Anderson // Lasers in Surgery and Medicine. 2009. Vol. 41, iss. 3. P. 185–188.
19. Bernstein E.F., Brown D.B., Kenkel J., Burns A.J. Resurfacing of different types of facial acne scars with short-pulsed, variable-pulsed, and dual-mode Er: YAG laser / E.F. Bernstein, D.B. Brown, J. Kenkel, A.J. Burns // Dermatologic Surgery. 1999. Vol. 25, iss. 10. P. 739–744.
20. Eggleston T.A., Godar P.M., Sliney H.F. Comparison of two porcine skin models for in vivo near-infrared laser exposure / T.A. Eggleston, P.M. Godar, H.F. Sliney // Comparative Medicine. 2000. Vol. 50, iss. 4. P. 391–397.
Review
For citations:
Sodel O.S., Akhmedbaeva I.A., Gryazeva N.V. Skin regeneration with plasma: a review of current concepts on technology, mechanisms of action, and clinical efficacy (literature review). Medical alphabet. 2026;(3):23-26. (In Russ.) https://doi.org/10.33667/2078-5631-2026-3-23-26
Views:
77
JATS XML
Email this article 