medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2026-3-23-26medalphabet-4943Research ArticleСтатьиРегенерация кожи с помощью плазмы: обзор современных представлений о технологии, механизмах действия и клинической эффективности (обзор литературы)Skin regeneration with plasma: a review of current concepts on technology, mechanisms of action, and clinical efficacy (literature review)https://orcid.org/0009-0007-7692-6888СодельО. С.SodelO. S.

Содель Ольга Сергеевна, врач косметолог, главный врач клиники

Москва

Sodel Olga S., cosmetologist, chief physician of the Clinic

Moscow

Osod515@gmail.comhttps://orcid.org/0000-0003-0641-8232АхмедбаеваИ. А.AkhmedbaevaI. A.

Ахмедбаева Инга Александровна, к.м.н., доцент кафедры дерматовенерологии и косметологии

Москва

Akhmedbaeva Inga A., PhD Med Sc, associate professor at Dept of Dermatovenereology and Cosmetology

Moscow

ingapm@yandex.ruhttps://orcid.org/0000-0003-3437-5233ГрязеваН. В.GryazevaN. V.

Грязева Наталья Владимировна, д.м.н., профессор кафедры дерматовенерологии и косметологии

Москва

Gryazeva Natalya V., Dr Med Sci (habil.), professor at Dept of Dermatovenereology and Cosmetology

Moscow

tynrik@yandex.ruКосметологическая клиника «Skin Lift Clinic»РоссияSkin Lift ClinicRussian FederationФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy of the Administrative Department of the President of Russian FederationRussian Federation20261404202603Дерматология (1)2326Copyright © Содель О.С., Ахмедбаева И.А., Грязева Н.В., 20262026Содель О.С., Ахмедбаева И.А., Грязева Н.В.Sodel O.S., Akhmedbaeva I.A., Gryazeva N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4943

Регенерация кожи плазмой (PSR) представляет собой современную неаблативную технологию аппаратного омоложения, основанную на использовании контролируемого термического воздействия ионизированного газа (плазмы). В обзоре систематизированы фундаментальные физические принципы метода, в частности, ключевые различия между двумя основными типами используемой плазмы – азотной (N2) и гелиевой (He), определяющие особенности механизма их действия. Подробно рассмотрены уникальные гистологические изменения, индуцируемые PSR,– формирование зоны термического повреждения (ZTD) и зоны термической модификации (ZTM), что лежит в основе патогенеза последующей реэпителизации и неоколлагенеза. Приведены данные о динамике восстановления тканей и основных клинических эффектах, включая эффект «биологической повязки», улучшение текстуры кожи и лифтинг. Приведены сравнительные данные PSR с аблятивным CO2-лазером, определены показания клинического применения каждой технологии. В статье обсуждаются показания к применению PSR, профиль безопасности, возможные осложнения и противопоказания. Сделан вывод о том, что PSR занимает важное место в арсенале эстетической медицины как метод, обеспечивающий предсказуемый омолаживающий эффект при относительно коротком периоде реабилитации и высоком уровне безопасности для различных фототипов кожи.

Plasma-assisted skin regeneration (PSR) is a modern non-ablative hardware-assisted rejuvenation technology based on the controlled thermal action of ionized gas (plasma). This review systematizes the fundamental physical principles of the method, in particular, the key differences between the two main types of plasma used – nitrogen (N2) and helium (He), which determine the features of their mechanism of action. The unique histological changes induced by PSR are considered in detail – the formation of the zone of thermal damage (ZTD) and the zone of thermal modification (ZTM), which underlie the pathogenesis of subsequent re-epithelialization and neocollagenesis. Data on the dynamics of tissue regeneration and the main clinical effects are presented, including the «biological dressing» effect, improved skin texture, and lifting. Comparative data of PSR with an ablative CO2 laser are presented, and the clinical indications for each technology are determined. The article discusses the indications for the use of PSR, its safety profile, possible complications, and contraindications. It is concluded that PSR occupies an important place in the arsenal of aesthetic medicine as a method that provides a predictable rejuvenating effect with a relatively short recovery period and a high level of safety for various skin phototypes.

плазменная регенерация кожиPSRнеаблативное омоложениеазотная плазмагелиевая плазматепловое повреждениеколлагенгистологияplasma skin regenerationPSRnon-ablative rejuvenationnitrogen plasmahelium plasmathermal damagecollagenhistologyReferencesFoster K.W., Moy R.L., Fincher E.F. Advances in plasma skin regeneration / K.W. Foster, R.L. Moy, E.F. Fincher // Journal of Cosmetic Dermatology. 2008. Vol. 7, iss. 3. P. 169–179.Foster K.W., Moy R.L., Fincher E.F. Advances in plasma skin regeneration / K.W. Foster, R.L. Moy, E.F. Fincher // Journal of Cosmetic Dermatology. 2008. Vol. 7, iss. 3. P. 169–179.Bentkover S.H. Plasma skin resurfacing: Personal experience and long-term results / S.H. Bentkover // Facial Plastic Surgery Clinics of North America. 2012. Vol. 20, iss. 2. P. 145–162.Bentkover S.H. Plasma skin resurfacing: Personal experience and long-term results / S.H. Bentkover // Facial Plastic Surgery Clinics of North America. 2012. Vol. 20, iss. 2. P. 145–162.Kilmer S., Semchyshyn N., Shah G., Fitzpatrick R. A pilot study on the use of a plasma skin regeneration device (Portrait PSR3) in full facial rejuvenation procedures / S. Kilmer, N. Semchyshyn, G. Shah, R. Fitzpatrick // Lasers in Medical Science. 2007. Vol. 22, iss. 2. P. 101–109.Kilmer S., Semchyshyn N., Shah G., Fitzpatrick R. A pilot study on the use of a plasma skin regeneration device (Portrait PSR3) in full facial rejuvenation procedures / S. Kilmer, N. Semchyshyn, G. Shah, R. Fitzpatrick // Lasers in Medical Science. 2007. Vol. 22, iss. 2. P. 101–109.Elsaie M.L., Kammer J.N. Evaluation of plasma skin regeneration technology for cutaneous remodeling / M.L. Elsaie, J.N. Kammer // Journal of Cosmetic Dermatology. 2008. Vol. 7, iss. 4. P. 309–311.Elsaie M.L., Kammer J.N. Evaluation of plasma skin regeneration technology for cutaneous remodeling / M.L. Elsaie, J.N. Kammer // Journal of Cosmetic Dermatology. 2008. Vol. 7, iss. 4. P. 309–311.Bogle M.A., Arndt K.A., Dover J.S. Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation / M.A. Bogle, K.A. Arndt, J.S. Dover // Archives of Dermatology. 2007. Vol. 143, iss. 2. P. 168–174.Bogle M.A., Arndt K.A., Dover J.S. Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation / M.A. Bogle, K.A. Arndt, J.S. Dover // Archives of Dermatology. 2007. Vol. 143, iss. 2. P. 168–174.Holcomb J.D., Schucker A. Helium Plasma Skin Regeneration: Evaluation of Skin Tissue Effects in a Porcine Model and Comparison to Nitrogen Plasma Skin Regeneration / J.D. Holcomb, A. Schucker // Lasers in Surgery and Medicine. 2020. Vol. 52, iss. 1. P. 23–32.Holcomb J.D., Schucker A. Helium Plasma Skin Regeneration: Evaluation of Skin Tissue Effects in a Porcine Model and Comparison to Nitrogen Plasma Skin Regeneration / J.D. Holcomb, A. Schucker // Lasers in Surgery and Medicine. 2020. Vol. 52, iss. 1. P. 23–32.Current J.D. Physics Related to Anesthesia: учебник / J.D. Current; ред. J.D. Current. 2nd ed. 1999. Гл. 3: Vaporization [Heat Capacity]. С. [указать страницы].Current J.D. Physics Related to Anesthesia: учебник / J.D. Current; ред. J.D. Current. 2nd ed. 1999. Гл. 3: Vaporization [Heat Capacity]. С. [указать страницы].Fitzpatrick R., Bernstein E.F., Harris D.M., Kilmer S.M. A Histopathologic Evaluation of the Plasma Skin Regeneration System (PSR) Versus a Standard Carbon Dioxide Resurfacing Laser in an Animal Model / R. Fitzpatrick, E.F. Bernstein, D.M. Harris, S.M. Kilmer // Lasers in Surgery and Medicine. 2008. Vol. 40, iss. 2. P. 93–99.Fitzpatrick R., Bernstein E.F., Harris D.M., Kilmer S.M. A Histopathologic Evaluation of the Plasma Skin Regeneration System (PSR) Versus a Standard Carbon Dioxide Resurfacing Laser in an Animal Model / R. Fitzpatrick, E.F. Bernstein, D.M. Harris, S.M. Kilmer // Lasers in Surgery and Medicine. 2008. Vol. 40, iss. 2. P. 93–99.Lee R.C. Tissue injury from exposure to power frequency electrical fields / R.C. Lee // Advances in Electromagnetic Fields in Living Systems / ed. by J.C. Lin. Plenum Press, 1994. Т. 1. С. 81–127.Lee R.C. Tissue injury from exposure to power frequency electrical fields / R.C. Lee // Advances in Electromagnetic Fields in Living Systems / ed. by J.C. Lin. Plenum Press, 1994. Т. 1. С. 81–127.Olhoffer I.H., Leffell D.J. Bipolar radiofrequency for facial rejuvenation / I.H. Olhoffer, D.J. Leffell // Aesthetic Dermatology and Cosmetic Surgery. 1999. Vol. 1, iss. 1. P. 31–33.Olhoffer I.H., Leffell D.J. Bipolar radiofrequency for facial rejuvenation / I.H. Olhoffer, D.J. Leffell // Aesthetic Dermatology and Cosmetic Surgery. 1999. Vol. 1, iss. 1. P. 31–33.Pedroso J.D., Pedroso A.C. D., Nahas S.C., Ribeiro U.R. Thermal effect of J-Plasma in a porcine tissue model: Implications for minimally invasive surgery / J.D. Pedroso, A. C.D. Pedroso, S.C. Nahas, U.R. Ribeiro // Surgical Technology International. 2017. Vol. 30. P. 19–24.Pedroso J.D., Pedroso A.C. D., Nahas S.C., Ribeiro U.R. Thermal effect of J-Plasma in a porcine tissue model: Implications for minimally invasive surgery / J.D. Pedroso, A. C.D. Pedroso, S.C. Nahas, U.R. Ribeiro // Surgical Technology International. 2017. Vol. 30. P. 19–24.Flint M.H., Lyons M.F. The effect of heating and denaturation on the staining of collagen by the Masson trichome procedure / M.H. Flint, M.F. Lyons // Histochemical Journal. 1975. Vol. 7, iss. 6. P. 547–555.Flint M.H., Lyons M.F. The effect of heating and denaturation on the staining of collagen by the Masson trichome procedure / M.H. Flint, M.F. Lyons // Histochemical Journal. 1975. Vol. 7, iss. 6. P. 547–555.Potter M.J., Harrison D.M., Bennett R.G. Facial acne and fine lines: Transforming patient outcomes with plasma skin regeneration / M.J. Potter, D.M. Harrison, R.G. Bennett // Annals of Plastic Surgery. 2007. Vol. 58, iss. 6. P. 608–613.Potter M.J., Harrison D.M., Bennett R.G. Facial acne and fine lines: Transforming patient outcomes with plasma skin regeneration / M.J. Potter, D.M. Harrison, R.G. Bennett // Annals of Plastic Surgery. 2007. Vol. 58, iss. 6. P. 608–613.Theppornpitak N., Kamanamool C., Udompatikul P., Srisawat M. Nitrogen plasma skin regeneration for the treatment of mild-to-moderate peri-orbital wrinkles / N. Theppornpitak, C. Kamanamool, P. Udompatikul, M. Srisawat // Journal of Cosmetic Dermatology. 2019. Vol. 18, iss. 1. P. 163–168.Theppornpitak N., Kamanamool C., Udompatikul P., Srisawat M. Nitrogen plasma skin regeneration for the treatment of mild-to-moderate peri-orbital wrinkles / N. Theppornpitak, C. Kamanamool, P. Udompatikul, M. Srisawat // Journal of Cosmetic Dermatology. 2019. Vol. 18, iss. 1. P. 163–168.Holcomb J.D. Nitrogen plasma skin regeneration and aesthetic facial surgery: Multicenter evaluation of concurrent treatment / J.D. Holcomb // Archives of Facial Plastic Surgery. 2009. Vol. 11, iss. 3. P. 184–193.Holcomb J.D. Nitrogen plasma skin regeneration and aesthetic facial surgery: Multicenter evaluation of concurrent treatment / J.D. Holcomb // Archives of Facial Plastic Surgery. 2009. Vol. 11, iss. 3. P. 184–193.Kono T., Chan A.R., Groff H.H., Yamaki T. Treatment of traumatic scars using plasma skin regeneration (PSR) system / T. Kono, A.R. Chan, H.H. Groff, T. Yamaki // Lasers in Surgery and Medicine. 2009. Vol. 41, iss. 2. P. 128–130.Kono T., Chan A.R., Groff H.H., Yamaki T. Treatment of traumatic scars using plasma skin regeneration (PSR) system / T. Kono, A.R. Chan, H.H. Groff, T. Yamaki // Lasers in Surgery and Medicine. 2009. Vol. 41, iss. 2. P. 128–130.Ross E.V., McKinlay J. R., Anderson R.R. Comparison of carbon dioxide laser, erbium: YAG laser, dermabrasion, and dermatome: a study of thermal damage, wound contraction, and wound healing in a live pig model: implications for skin resurfacing / E.V. Ross, J.R. McKinlay, R.R. Anderson // Archives of Dermatology. 1999. Vol. 135, iss. 4. P. 444–454.Ross E.V., McKinlay J. R., Anderson R.R. Comparison of carbon dioxide laser, erbium: YAG laser, dermabrasion, and dermatome: a study of thermal damage, wound contraction, and wound healing in a live pig model: implications for skin resurfacing / E.V. Ross, J.R. McKinlay, R.R. Anderson // Archives of Dermatology. 1999. Vol. 135, iss. 4. P. 444–454.Avram M.M., Tope T.S. H., Yu T., Dover J.S., Anderson R.R. Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing / M.M. Avram, T. S.H. Tope, T. Yu, J.S. Dover, R.R. Anderson // Lasers in Surgery and Medicine. 2009. Vol. 41, iss. 3. P. 185–188.Avram M.M., Tope T.S. H., Yu T., Dover J.S., Anderson R.R. Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing / M.M. Avram, T. S.H. Tope, T. Yu, J.S. Dover, R.R. Anderson // Lasers in Surgery and Medicine. 2009. Vol. 41, iss. 3. P. 185–188.Bernstein E.F., Brown D.B., Kenkel J., Burns A.J. Resurfacing of different types of facial acne scars with short-pulsed, variable-pulsed, and dual-mode Er: YAG laser / E.F. Bernstein, D.B. Brown, J. Kenkel, A.J. Burns // Dermatologic Surgery. 1999. Vol. 25, iss. 10. P. 739–744.Bernstein E.F., Brown D.B., Kenkel J., Burns A.J. Resurfacing of different types of facial acne scars with short-pulsed, variable-pulsed, and dual-mode Er: YAG laser / E.F. Bernstein, D.B. Brown, J. Kenkel, A.J. Burns // Dermatologic Surgery. 1999. Vol. 25, iss. 10. P. 739–744.Eggleston T.A., Godar P.M., Sliney H.F. Comparison of two porcine skin models for in vivo near-infrared laser exposure / T.A. Eggleston, P.M. Godar, H.F. Sliney // Comparative Medicine. 2000. Vol. 50, iss. 4. P. 391–397.Eggleston T.A., Godar P.M., Sliney H.F. Comparison of two porcine skin models for in vivo near-infrared laser exposure / T.A. Eggleston, P.M. Godar, H.F. Sliney // Comparative Medicine. 2000. Vol. 50, iss. 4. P. 391–397.

The authors declare that there are no conflicts of interest present.