Epidemiological situation of enterovirus infection in the Russian Federation and neighboring countries
S. N. Ionov,
O. A. Pivovarova,
A. A. Akhtanina,
F. N. Paleev,
A. A. Kotova,
А. V. Glotov,
O. V. Koroleva,
N. V. Mirzonova https://doi.org/10.33667/2078-5631-2025-34-36-42
Abstract
Acute intestinal infections (AII) constitute a significant proportion of the global burden of infectious diseases, ranking second only to acute respiratory viral infections in terms of economic impact. In the Russian Federation (RF), the incidence of AII of established and unspecified etiology in 2024 was 456.56 per 100,000 population, with the overall incidence among children reaching 1,534.1 per 100,000 population. In 2024, viral AII outbreaks continued to predominate, with noroviruses accounting for 42.2 % (302 outbreaks) and rotaviruses for 14.7 % (105 outbreaks). A notable feature of the past year's group morbidity was an increased proportion of enterovirus infection (EVI) foci within the overall structure of foci with a fecal-oral transmission mechanism, placing EVI foci second in the overall structure at 24.9 % (178 foci) [1]. This article analyzes statistical data from domestic and foreign authors on the epidemiology of enterovirus infection (EVI). A comparative analysis of the infectious process caused by different enterovirus serotypes, the prevalence of the disease in the Russian Federation and worldwide, and recommendations for preventive measures are provided. Based on the conducted reviews, a forecast for the expected incidence of enterovirus infection in the Russian Federation is presented.
About the Authors
S. N. Ionov
State University of Education
Russian Federation
Russian Federation
Ionov Stanislav N., Dr Bio Sci (habil.), professor
Moscow
O. A. Pivovarova
State University of Education
Russian Federation
Russian Federation
Pivovarova Oksana A., Dr Med Sci (habil.), professor
Moscow
A. A. Akhtanina
State University of Education
Russian Federation
Russian Federation
Akhtanina Alena A., assistant
Moscow
F. N. Paleev
State University of Education
Russian Federation
Russian Federation
Paleev Filipp N., Dr Med Sci (habil.), RAS corresponding membe, professor
Moscow
A. A. Kotova
State University of Education
Russian Federation
Russian Federation
Kotova Alevtina A., PhD Med, associate professor
Moscow
А. V. Glotov
State University of Education
Russian Federation
Russian Federation
Glotov Andrey V., Dr Med Sci (habil.), professor
Moscow
O. V. Koroleva
State UniverOsity of Education
Russian Federation
Russian Federation
Koroleva Olga V., assistant
Moscow
N. V. Mirzonova
State University of Education
Russian Federation
Russian Federation
Mirzonova Nadezhda V., medical student
Moscow
References
1. On the state of sanitary and epidemiological well-being of the population in the Russian Federation in 2024: State report. Moscow: Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 2025. 424p. (In Russ.).
2. Sanitary and epidemiological requirements for the prevention of infectious diseases: Sanitary rules and norms SanPiN 3.3686–21. M., 2021. 995 p. (In Russ.).
3. Enterovirus (non-polio) infectious diseases / E. I. Petrova et al. Tomsk: SibGMU Publishing House, 2023. 76 p. (In Russ.).
4. Romanenkova N. I., Bichurina M. A., Golitsyna L. N. Non-poliomyelitis enteroviruses that caused an increase in enterovirus infection incidence in several regions of Russia in 2016. Journal of Infectology. 2017; 3 (9): 98–108. (In Russ.).
5. Harvala H., Broberg E., Benschop K. et al. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe / H. Harvala, E. Broberg, K. Benschop [et al.]. Journal of clinical virology. 2018; 101: 11–17.
6. Helfferich J., Meiners L. C., Brouwer O. F. Acute flaccid weakness associated with enterovirus D 68 / J. Helfferich, L. C. Meiners, O. F. Brouwer. European journal of paediatric neurology. 2017; 21 (3): 594–595.
7. Kanbayashi D., Kaida A., Yamamoto S. P. et al. Impact of Coxsackievirus A6 emergence on hand, foot, and mouth disease epidemic in Osaka City, Japan / D. Kanbayashi, A. Kaida, S. P. Yamamoto [et al.]. Journal of medical virology. 2017; 89 (12): 2116–2121.
8. Magnelli D., Zammarchi L., Antonelli A. et al. Atypical hand, foot and mouth disease due to Coxsackievirus A6 in a traveler returning from Indonesia to Italy / D. Magnelli, L. Zammarchi, A. Antonelli [et al.]. Journal of travel medicine. 2017; 24 (5). DOI: 10.1093/jtm/tax029
9. Messacar K., Asturias E. J., Hixon A. M. et al. Enterovirus D 68 and acute flaccid myelitis – evaluating the evidence for causality / K. Messacar, E. J. Asturias, A. M. Hixon [et al.]. The Lancet. Infectious diseases. 2018. DOI: 10.1016/S1473-3099(18)30094-X
10. Butakova L. V., Trotsenko O. E., Sapega E. Yu. Enterovirus infection: overview of the current global situation in the context of intensified migration flows. Public Health and Life. 2018; (4): 55–60. (In Russ.).
11. Sapega E. Yu., Yanovich V. A., Trotsenko O. E., Onishchenko G. G., Korita T. V. et al. Epidemiological features of enterovirus infection during flooding in the territory of the Jewish Autonomous Region. Problems of Particularly Dangerous Infections. 2014; (1): 71–74. (In Russ.).
12. Incidence, etiological structure, and prevention issues of enterovirus infection // Information Bulletin of the Reference Center for Monitoring Enterovirus Infections. Federal State Budgetary Institution «NNIEM named after Academician I. N. Blokhina» of Rospotrebnadzor, May 2023, Nizhny Novgorod. 30 p. Authors: Novikova N. A., Golitsyna L. N. (In Russ.).
13. Romanenkova N. I., Bichurina M. A., Golitsyna L. N. Non-poliomyelitis enteroviruses that caused an increase in enterovirus infection incidence in several regions of Russia in 2016. Journal of Infectology. 2017; 3 (9): 98–108. (In Russ.).
14. Harvala H., Broberg E., Benschop K. et al. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe / H. Harvala, E. Broberg, K. Benschop [et al.]. Journal of clinical virology. 2018; 101: 11–17.
15. Helfferich J., Meiners L. C., Brouwer O. F. Acute flaccid weakness associated with enterovirus D 68 / J. Helfferich, L. C. Meiners, O. F. Brouwer. European journal of paediatric neurology. 2017; 21 (3): 594–595.
16. Kanbayashi D., Kaida A., Yamamoto S. P. et al. Impact of Coxsackievirus A6 emergence on hand, foot, and mouth disease epidemic in Osaka City, Japan / D. Kanbayashi, A. Kaida, S. P. Yamamoto [et al.]. Journal of medical virology. 2017; 89 (12): 2116–2121.
17. Magnelli D., Zammarchi L., Antonelli A. et al. Atypical hand, foot and mouth disease due to Coxsackievirus A6 in a traveler returning from Indonesia to Italy / D. Magnelli, L. Zammarchi, A. Antonelli [et al.]. Journal of travel medicine. 2017; 24 (5). DOI: 10.1093/jtm/tax029
18. Messacar K., Asturias E. J., Hixon A. M. et al. Enterovirus D 68 and acute flaccid myelitis – evaluating the evidence for causality / K. Messacar, E. J. Asturias, A. M. Hixon [et al.]. The Lancet. Infectious diseases. 2018. DOI: 10.1016/S1473-3099(18)30094-X
19. Onishchenko G. G., Popova A. Yu., Yezhlova E. B., Smolensky V. Yu., Demina Yu.V. et al. Enterovirus infection in the southern subjects of the Russian Federation (epidemiology, diagnosis, clinic, prevention). Edited by G. G. Onishchenko. Rostov-on-Don, 2016. (In Russ.).
20. Zayats N. A., Zhiteneva E. V., Serova Yu.S., Khitrova M. A. Dynamics of enterovirus infection incidence in the Saratov region // Bulletin of Medical Internet Conferences. 2019; 9 (12): 529. (In Russ.).
21. Romanenkova N. I., Bichurina M. A., Golitsyna L. N. Non-poliomyelitis enteroviruses that caused an increase in enterovirus infection incidence in several regions of Russia in 2016 // Journal of Infectology. 2017; 3 (9): 98–108. (In Russ.).
22. Internet resource. Official WHO website. https://www.who.int/ru/emergencies/disease-outbreak-news/item/2023-DON474
Review
For citations:
Ionov S.N., Pivovarova O.A., Akhtanina A.A., Paleev F.N., Kotova A.A., Glotov А.V., Koroleva O.V., Mirzonova N.V. Epidemiological situation of enterovirus infection in the Russian Federation and neighboring countries. Medical alphabet. 2025;1(34):36-42. (In Russ.) https://doi.org/10.33667/2078-5631-2025-34-36-42
Views:
136
JATS XML
Email this article 