Current issues in epidemiology and prevention of pneumonia associated with artificial lung ventilation
https://doi.org/10.33667/2078-5631-2025-29-25-30
Abstract
From 2016 to the present, hospital-acquired pneumonia has been the leading cause of healthcare-associated infections in the Russian Federation. Pneumonia associated with artificial lung ventilation is an independent risk factor for mortality, and the costs associated with its treatment range from $ 9,966 to EUR 20,965. A generalized strategy for the prevention of pneumonia associated with artificial lung ventilation is presented, which includes: ensuring the safety of the hospital environment, ensuring the safety of patient medical technologies, early detection of patients with signs of infectious diseases, and training of medical personnel. It is necessary to consolidate specialists from various fields to systematize best practices and develop guidelines at the national and regional levels.
About the Authors
O. A. OrlovaRussian Federation
Orlova Oksana A., Dr Med Sci (habil.), leading researcher at Laboratory of Infections Associated with Healthcare, epidemiologist, head of Dept of Epidemiology, senior researcher at the Laboratory of Opportunistic Infections
Moscow
A. V. Tutelyan
Russian Federation
Tutelyan Aleksey V., Dr Med Sci (habil.), RAS academician, head of the Laboratory of Healthcare-Associated Infections
Moscow
O. A. Abrosimova
Russian Federation
Abrosimova Olga A., head of the Epidemiological Service – Epidemiologist
Moscow
V. G. Akimkin
Russian Federation
Akimkin Vasily G., Dr Med Sci (habil.), professor, RAS academician, director
Moscow
References
1. Rosenthal V. D., Memish Z. A., Bearman G. еt al. Preventing ventilator-associated pneumonia: A position paper of the International Society for Infectious Diseases, 2024 update // Int. J. Infect. Dis. 2025. Feb:151:107305. DOI: 10.1016/j.ijid.2024.107305.
2. О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2024 году: Государственный доклад. М.: Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека, 2025. 424 с. https://www.rospotrebnadzor.ru/upload/iblock/b8a/u6lsxjabw032jkdf837nlaezxu3ue09m/GD_SEB.pdf.
3. Polibin R. V., Brusina E. B., Kovalishena O. V., et al. Epidemiological interregional multicenter study of healthcare-associated infections in intensive care units (ICUs). First results // Epidemiology and Vaccine Prevention. 2025; 24 (1): 4–9. (In Russ.). DOI.10.31631/2073-3046-2025-24-1-4-9
4. Rosenthal V. D., Yin R., Lu Y. еt al. The impact of healthcare-associated infections on mortality in ICU: a prospective study in Asia, Africa, Eastern Europe, Latin America, and the Middle East. Am. J. Infect. Control. 2023; 51 (6): 675–682. DOI: 10.1016/j.ajic.2022.08.024
5. Stone P. W. Economic burden of healthcare-associated infections: an American perspective. Expert Rev. Pharmacoecon Outcomes Res. 2009; 9 (5): 417–422. DOI: 10.1586/erp.09.53
6. Cabrera-Tejada G.G., Chico-Sanchez P., Gras-Valenti P. еt al. Estimation of additional costs in patients with ventilator-associated pneumonia. Antibiotics (Basel). 2023 Dec 19;13 (1): 2. DOI: 10.3390/antibiotics13010002
7. Klompas M., Branson R., Cawcutt K. еt al. Strategies to prevent ventilator-associated pneumonia, ventilator-associated events, and nonventilator hospital-acquired pneumonia in acute-care hospitals: 2022 Update. Infect. Control. Hosp. Epidemiol. 2022; 43(6): 687–713. DOI: 10.1017/ice.2022.88
8. Liu J., Zhang S., Chen J. et al. Risk factors for ventilator-associated events: A prospective cohort study. Am. J. Infect. Control. 2019; 47 (7): 744–749. DOI: 10.1016/j.ajic.2018.09.032
9. Perfilieva D. Yu., Miroshnichenko A. G., Perfil'ev V. Yu., et al. Clinical and epidemiological characteristics of patients with infections associated with previous hospitalization. Siberian Medical Review. 2023; 5: 81–87. (In Russ.). DOI: 10.20333/25000136-2023-5-81-87
10. Ignatenko O. V., Bykov A. O., Tyurin I. N., et al. Evaluation of the effectiveness of the protocol for the prevention of nosocomial pneumonia associated with mechanical ventilation. Saltanov Bulletin of Intensive Care. 2018; 3: 39–45. (In Russ.). DOI:0.21320/1818%474X%2018%3%39%45
11. Kudryavtseva L. G., Sergeevnin V. I., Pegushina O. G., et al. Frequency of isolation of pathogens causing nosocomial pneumonia from the respiratory tract of patients of a cardiac surgery hospital undergoing prolonged mechanical ventilation, and the effectiveness of oral cavity sanitation with chlorhexidine solution. Perm Medical Journal. 2023; 40 (3): 28–35. (In Russ.). DOI: 10.17816/pmj40328 35
12. Lokotkova A. I., Shlyapchenkova T. Yu., Mamkeev E. Kh., et al. Analysis of the etiological structure of nosocomial pneumonia associated with mechanical ventilation. Medical Almanac. 2019; 3–4 (60): 86–88. (In Russ.). DOI: 10.21145/2499–995.4-2019-3-86-88
13. Nosocomial pneumonia in adults: Russian national guidelines. Edited by Academician of the Russian Academy of Sciences B. R. Gelfand; responsible editors: Cand. Sci. (Med.), Associate Professor D. N. Protsenko, Cand. Sci. (Med.), Associate Professor B. Z. Belotserkovsky. 2nd ed., revised and enlarged. Moscow: Medical Information Agency Publishing House, 2016; 176 p. (In Russ.).
14. Karpov O. E., Gusarov V. G., Kamyshova D. A. et al. Evaluation of the effectiveness of the antibiotic resistance containment strategy: results of a ten-year study in a multidisciplinary hospital. Clinical Microbiology and Antimicrobial Chemotherapy. 2023; 25 (3): 283–295. (In Russ.). DOI:10.36488/cmac.2023.3.283295
15. Martinez-Reviejo R., Tejada S., Jansson M. et al. Prevention of ventilator-associated pneumonia through care bundles: a systematic review and meta-analysis. J. Intensive Med. 2023; 3: 352–364. DOI: 10.1016/j.jointm.2023.04.004.
16. Rehmani A. I., Au A., Montgomery C. et al. Use of nursing care bundles for the prevention of ventilator-associated pneumonia in low-middle income countries: A scoping review. Nurs Crit Care. 2024; 29 (6): 1511–1534. DOI:10.1111/nicc.13076
17. Houghton C., Meskell P., Delaney H. et al. Barriers and facilitators to healthcare workers' adherence with infection prevention and control (IPC) guidelines for respiratory infectious diseases: a rapid qualitative evidence synthesis. Cochrane Database Syst. Rev. 2020 Apr 21; 4 (4): CD 013582. DOI:10.1002/14651858.CD 013582
18. Croft K., Dallal-York J., Miller S. et al. Provision of Oral Care in the Cardiothoracic Intensive Care Unit: Survey of Nursing Staff Training, Confidence, Methods, Attitudes, and Perceived Barriers. J. Contin. Educ. Nurs. 2023; 54 (7): 313–321. DOI: 10.3928/00220124-20230620-02
19. Henriksen K., Isaacson S., Sadler B. L. et al. The role of the physical environment in crossing the quality chasm. J. Comm. J. Qual. Patient. Saf. 2007; 33 (11 Suppl): 68–80. DOI: 10.1016/s1553–7250 (07) 33114-0
20. Ulrich R., Quan X., Zimring C. P. et al. The role of the physical environment in the hospital of the 21st century: a once-in-a-lifetime opportunity. The Center for Health Design, 2004. https://healingphotoart.org/wp-content/uploads/2012/11/UlrichPhyEnviron.pdf.
21. Allegranzi B., Pittet D. Role of hand hygiene in healthcare-associated infection prevention. J. Hosp. Infect. 2009; 73 (4): 305–315. DOI: 10.1016/j.jhin.2009.04.019
22. Otchwemah R., Sons D., Senges C. et al. Observing is influencing: How hand disinfection compliance observations affect hand disinfection rates; specifics derived from an electronic monitoring system. Articles in Press June 26, 2025. DOI: 10.1016/j.ajic.2025.06.020
23. Bijarania S. K., Kaur R., Biswal M. et al. A multimedia tool for infection prevention and control practices in the intensive care unit: a participatory interventional before-after study. Infect. Prev. Pract. 2024. Dec 5; 7 (1): 100423. DOI: 10.1016/j.infpip.2024.100423
24. Brusina E. B. Microbiome of the hospital environment. Journal of Microbiology, Epidemiology and Immunobiology. 2024; 101 (3): 393–398. (In Russ.). DOI:10.36233/0372-9311-520
25. Nagolkin A. V., Volodina E. V., Akimkin V. G., et al. Modern scientific and practical trends in the field of air disinfection in medical organizations. Population Health and Habitat. 2016; 2: 47–51. (In Russ.).
26. Wu Y., Li Y, Sun M. et al. Continuous versus intermittent control cuff pressure for preventing ventilator-associated pneumonia: an updated meta-analysis. J. Intensive Care Med. 2024; 39 (9): 829–839. DOI: 10.1177/08850666241232369
27. Grotowska M., Skalec T., Wójtowicz I. et al. Early tracheostomy in ventilated COVID-19 patients reduces incidence of ventilator-associated pneumonia. Sci. Rep. 2024 Nov 27; 14 (1): 29472. DOI: 10.1038/s41598-024-81115-5.
28. Sanai S., Rahnemayan S., Javan S. et al. Comparison of closed vs open suction in prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Indian J. Crit. Care Med. 2022; 26 (7): 839–845. DOI: 10.5005/jp-journals-10071–24252
29. Tincu R. C., Cobilinschi C., Tincu I. F. et al. Efficacy of noble metal-alloy endotracheal tubes in ventilator-associated pneumonia prevention: a randomized clinical trial. Balkan. Med. J. 2022; 39: 167–171. DOI: 10.4274/balkanmedj.galenos.2021.2021-7-86
30. Damas P., Legrain C., Lambermont B. et al. Prevention of ventilator-associated pneumonia by noble metal coating of endotracheal tubes: a multi-center, randomized, double-blind study. Ann Intensive Care. 2022 Jan 4; 12 (1):1. DOI: 10.1186/s13613–021–00961-y
31. Liu C., Jiang J., Wen Z., You T. Naso-intestinal versus gastric tube for enteral nutrition in patients undergoing mechanical ventilation: a systematic review and meta-analysis. Syst. Rev. 2025 Jan 14; 14 (1): 13. DOI: 10.1186/s13643-024-02743-6
32. Orlova O. A., Gusarov V. G., Kamyshova D. A., et al. Microbiological monitoring of patients in the infectious diseases intensive care unit. Epidemiology and infectious diseases. Current issues. 2025; 1: 67–73. (In Russ.). DOI: 10.18565/epidem.2025.15.1.67–73
33. Akimkin V. G. National system of microbiological monitoring of microorganisms resistant to antimicrobial drugs. Bulletin of the Russian Academy of Sciences. 2024; 1 (94): 4–10. (In Russ.). DOI: 10.31857/S0869587324010026
34. Getahun A. B., Belsti Y., Getnet M. et al. Knowledge of intensive care nurses’ towards prevention of ventilator-associated pneumonia in North West Ethiopia referral hospitals, 2021: a multicenter, cross-sectional study. Ann. Med. Surg. (Lond). 2022 Jun 3; 78: 103895. DOI: 10.1016/j.amsu.2022.103895
35. Abramov Yu.E., Timurzieva A. B., Orlova O. A., Akimkin V. G. Improving the system of prevention of infections associated with the provision of medical care and the fight against antibiotic resistance based on optimization of the interaction of participants in the treatment and diagnostic process // Population Health and Environment. 2023; 31 (8): 88–97. (In Russ.). DOI: 10.35627/2219–5238/2023-31-8-88-97
Review
For citations:
Orlova O.A., Tutelyan A.V., Abrosimova O.A., Akimkin V.G. Current issues in epidemiology and prevention of pneumonia associated with artificial lung ventilation. Medical alphabet. 2025;(29):25-30. (In Russ.) https://doi.org/10.33667/2078-5631-2025-29-25-30
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