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Pregnancy, labor, postpartum and neonatal outcomes in women with new coronavirus infection and preterm labor

https://doi.org/10.33667/2078-5631-2024-8-48-53

Abstract

We retrospectively analyzed 148 cases of new coronavirus infection in pregnant women in the second half of pregnancy between May 2020 and December 2021. Groups were divided according to gestational age: comparison group I (n=104) – deliveries from 37 weeks and over, term; main group II (n=44) – deliveries from 22 to 36+6 weeks preterm. Among pregnancy complications, women in the preterm labour group were 6.5 times more likely to have moderate anaemia than those in the term labour group (95% CI: 1.2–35.1). Severe pneumonia and its progression associated with SARS-CoV‑2 infection was the main indication for premature delivery. Consequently, the odds of caesarean section were 12.6 times higher (95% CI: 4.2–37.8) in the preterm labour group than in the on-time delivery group. Of these, the proportion of emergency caesarean section was 100% (44) (χ2 =3.61; p=0.13). Postpartum endometritis was 13.2 times more frequent in women in the preterm labour group than in the term labour group (95% CI: 1.4–11.6). Cases of sepsis in the postpartum period were recorded only in the preterm labour group – 6.8% (n=3), p<0,05. Newborns in the preterm labour group had lower birth weight and Apgar scores, which was primarily due to prematurity and required respiratory support and longer hospital treatment. In the preterm group, the odds of neonatal malformations were 4.6 times higher than in the term group (95% CI: 1.75–12.90). The new coronavirus infection in the absence of infection in the placenta was detected in one case 2.3% (n=1).

About the Authors

E. E. Chernaya
Khanty-Mansiysk State Medical Academy
Russian Federation

Chernaya Ekaterina E., PhD Med, assistant professor,

Khanty-Mansiysk.



E. I. Kutefa
District Clinical Hospital
Russian Federation

Kutefa Elena I., Head Doctor at the Hospital, Obstetrician-gynecologist, 

Khanty-Mansiysk.



A. E. Kasparova
Khanty-Mansiysk State Medical Academy
Russian Federation

Kasparova Angelika E., DM Sci (habil.), Assistant Professor, Professor, Head of the Dept of Obstetrics and Gynecology,

Khanty-Mansiysk.



E. N. Vasilkovskaya
District Clinical Hospital
Russian Federation

Vasilkovskaya Elena N., Deputy Head for Obstetrics and Gynecology,

Khanty-Mansiysk.



L. A. Chegus
Khanty-Mansiysk State Medical Academy
Russian Federation

Chegus Larisa A, PhD Med, Assistant Professor,

Khanty-Mansiysk.



S. I. Semenchenko
Khanty-Mansiysk State Medical Academy; District Clinical Hospital
Russian Federation

Semenchenko Sergey I., PhD Med, Assistant Professor; Obstetrician-gynecologist,

Khanty-Mansiysk.



References

1. Ashish K.C., Gurung R., Kinney M.V., Sunny A.K., Moinuddin M., Basnet O., Målqvist M. Effect of the COVID‑19 pandemic response on intrapartum care, stillbirth, and neonatal mortality outcomes in Nepal: A prospective observational study. The Lancet Global Health. 2020; 8 (10): e1273–e1281.

2. Khalil A., von Dadelszen P., Draycott T., Ugwumadu A., O’Brien P., Magee L. Change in the incidence of stillbirth and preterm delivery during the COVID‑19 pandemic. The Journal of the American Medical Association. 2020; 324 (7): 705–706.

3. Karimi L, Vahedian-Azimi A, Makvandi S, Sahebkar A. A Systematic Review of 571 Pregnancies Affected by COVID‑19. Adv. Exp. Med. Biol. 2021; 1321: 287–298. DOI: 10.1007/978–3–030–59261–5_26. PMID: 33656734.

4. Conde-Agudelo A., Romero R. SARS-CoV‑2 infection during pregnancy and risk of preeclampsia: A systematic review and meta-analysis. Am. J. Obstet. Gynecol. 2021. DOI: 10.1016/j.ajog.2021.07.009

5. Al Hashmi I, Khalaf A, Seshan V, Alsabti H, Al Omari O, Yehia D, Baqer M, Al Khadhuri J. Maternal and Neonatal Outcomes of Healthy Pregnant Women With COVID‑19 Versus High-risk Pregnant Women: A Multi-Center Case-Control Comparison Study. Clin. Nurs. Res. 2022 May; 31 (4): 702–712. DOI: 10.1177/10547738211064027. Epub 2021 Dec 26. PMID: 34955040.

6. Antoun L., Taweel N.E., Ahmed I., Patni S., Honest H. Maternal COVID‑19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2020; 252: 559–562. https://doi.org/10.1016/j.ejogrb.2020.07.008

7. Rottenstreich A., Tsur A., Braverman N., Kabiri D., Porat S., Benenson S., Oster Y., Kam H.A., Walfisch A., Bart Y., et al. Vaginal delivery in SARS-CoV‑2-infected pregnant women in Israel: A multicenter prospective analysis. Arch. Gynecol. Obstet. 2020; 303: 1401–1405. DOI: 10.1007/s00404–020–05854–2

8. Parazzini F, Bortolus R, Mauri PA, Favilli A, Gerli S, Ferrazzi E. Delivery in pregnant women infected with SARS-CoV‑2: A fast review. Int J. Gynaecol Obstet. 2020 Jul; 150 (1): 41–46. DOI: 10.1002/ijgo.13166. Epub 2020 May 1. PMID: 32271947; PMCID: PMC9087752.

9. Ashokka B, Mai-Han L, Tan CH, Su LL, Young BE, Lye DC, et al. Care of the pregnant woman with COVID‑19 in labor and delivery: anesthesia, emergency cesarean delivery, differential diagnosis in the acutely ill parturient, care of the newborn, and protection of the healthcare personnel. Am. J. Obstet. Gynecol. 2020.

10. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395: 497–506.

11. Akhtar H., Patel C., Abuelgasim E., Harky A. COVID‑19 (SARS-CoV‑2) infection in pregnancy: A systematic review. Gynecologic and Obstetric Investigation. 2020; 85 (4): 295–306. https://doi.org/10.1159/000509290

12. Li N., Han L., Peng M., Lv Y., Ouyang Y., Liu K., Yue L., Li Q., Sun G., Chen L., Yang L. Maternal and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID‑19) pneumonia: A case-control study. Clinical Infectious Diseases. 2020; 71 (16): 2035–2041. https://doi.org/10.1093/cid/ciaa352

13. Wang Y., Wang Y., Han X., Ye J., Li R. Potential effect of COVID‑19 on maternal and infant outcome: Lesson from SARS. Frontiers in Pediatrics. 2020; 8: 511. https://doi.org/10.3389/fped.2020.00511

14. Wei S. Q., Bilodeau-Bertrand M., Liu S., Auger N. The impact of COVID‑19 on pregnancy outcomes: A systematic review and meta-analysis. CMAJ: Canadian Medical Association journal = journal de l’Association medicale canadienne. 2021; 193 (16): E540–E548. https://doi.org/10.1503/cmaj.202604

15. Morán Antolín E, Broullón Molanes JR, de la Cruz Conty ML, Encinas Pardilla MB, Guadix Martín MDP, Sainz Bueno JA, Forcén Acebal L, Pintado Recarte P, Álvarez Bartolomé A, Martínez Cendán JP, Martínez-Pérez Ó, On Behalf of The Spanish Obstetric Emergency Group. SARS-CoV‑2 Infection and C-Section: A Prospective Observational Study. Viruses. 2021 Nov 22; 13 (11): 2330. DOI: 10.3390/v13112330. PMID: 34835136; PMCID: PMC8622813.

16. Methodological recommendations. Organization of medical care for pregnant women, women in labor, delivery women and newborns with new coronavirus infectionCOVID‑19. Version 4.0. 05.07.2021. (In Russian)

17. Ji X, Wu C, Chen M, Wu L, Li T, Miao Z, Lv Y, Ding H. Analysis of risk factors related to extremely and very preterm birth: a retrospective study. BMC Pregnancy Childbirth. 2022 Nov 5; 22 (1): 818. DOI: 10.1186/s12884–022–05119–7. PMID: 36335328; PMCID: PMC9636775.

18. Gurol-Urganci I, Jardine JE, Carroll F, Draycott T, Dunn G, Fremeaux A, Harris T, Hawdon J, Morris E, Muller P, Waite L, Webster K, van der Meulen J, Khalil A. Maternal and perinatal outcomes of pregnant women with SARS-CoV‑2 infection at the time of birth in England: national cohort study. Am. J. Obstet. Gynecol. 2021 Nov; 225 (5): 522.e1–522. e11. DOI: 10.1016/j.ajog.2021.05.016. Epub 2021 May 20. PMID: 34023315; PMCID: PMC8135190.

19. Dotters-Katz SK, Hughes BL. Considerations for Obstetric Care during the COVID‑19 Pandemic. Am.J. Perinatol. 2020 Jun; 37 (8): 773–779. DOI: 10.1055/s‑0040–1710051. Epub 2020 Apr 17. PMID: 32303077; PMCID: PMC7356077.

20. Mullins E, Perry A, Banerjee J, Townson J, Grozeva D, Milton R, Kirby N, Playle R, Bourne T, Lees C; PAN-COVID Investigators. Pregnancy and neonatal outcomes of COVID‑19: The PAN-COVID study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2022 Sep; 276: 161–167. DOI: 10.1016/j.ejogrb.2022.07.010. Epub 2022 Jul 19. PMID: 35914420; PMCID: PMC9295331.

21. Komine-Aizawa S, Takada K, Hayakawa S. Placental barrier against COVID‑19. Placenta. 2020 Sep 15; 99: 45–49. DOI: 10.1016/j.placenta.2020.07.022. Epub 2020 Jul 25. PMID: 32755724; PMCID: PMC7381919.

22. De Rose DU, Piersigilli F, Ronchetti MP, Santisi A, Bersani I, Dotta A, Danhaive O, Auriti C. Novel Coronavirus disease (COVID‑19) in newborns and infants: what we know so far. Ital. J. Pediatr. 2020; 46: 1–8.

23. Li M., Chen L., Zhang J., Xiong C., Li X. The SARS-CoV‑2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. PLoS One. 2020; 15: 1–12. DOI: 10.1371/journal.pone.023029


Review

For citations:


Chernaya E.E., Kutefa E.I., Kasparova A.E., Vasilkovskaya E.N., Chegus L.A., Semenchenko S.I. Pregnancy, labor, postpartum and neonatal outcomes in women with new coronavirus infection and preterm labor. Medical alphabet. 2024;(8):48-53. (In Russ.) https://doi.org/10.33667/2078-5631-2024-8-48-53

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ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)