Quality of life dynamics in patients with knee osteoarthritis on intra-articular therapy with bioactive concentrate of small sea fish and domestically produced sodium hyaluronate

Introduction. The quality of life in patients with osteoarthritis (OA) depends on the severity of functional disorders, pain syndrome and the efficacy of their pharmacological correction.

Purpose of the study. To evaluate the dynamics of the life quality in patients with knee osteoarthritis treated with intra-articular injections of domestically produced sodium hyaluronate (synovial fluid prosthesis) or with bioactive concentrate of small sea fish (BACSSF).

Materials and methods. 180 patients with knee osteoarthritis were examined. The study group consisted of 50 patients who received injections of sodium hyaluronate (prosthesis synovial fluid), intra-articularly. Comparison group included 30 patients treated with BACSSF 2 ml No. 5 intraarticularly. Control group consisted of 100 patients who received BACSSF intramuscularly 1 ml No. 20. Study design: duration 12 months with prospective monitoring of quality of life according to the SF-36 scale, six visits.

Results. When included in the study, the level of physical and mental health components between the groups of patients differed statistically insignificantly (p = 0.369 and p = 0.089). According to the study results, used pharmacotherapy improved quality of life in all groups. However, the groups differed statistically significantly in the speed of achieving an analgesic effect, the severity of pain reduction and the duration of maintenance of the therapy effect. The best dynamics of the physical and mental components of health was in a group of patients with knee osteoarthritis treated with intra-articular sodium hyaluronate.

Conclusions. In real clinical practice, it is not always possible to improve the quality of life of patients with knee osteoarthritis. Symptomatic delayed-release medications (SYSADOA) are effective in the early stages of the disease. The positive clinical effect of intra-articular therapy with sodium hyaluronate develops earlier and lasts longer than therapy with another SYSADOA (BACSSF).

1. Poduzov A. A., Yazykova V. S. On the possibilities of assessing the subjective quality of life. Studies on Russian Economic Development. 2019; 5 (176). (In Russ.) https://cyberleninka.ru/article/n/o-vozmozhnostyah-otsenki-subektivnogo-kachestva-zhizni

2. Sivordova L.E., Polyakova Yu.V., Papichev E.V., et al. Assessment of the quality of life of patients with gonarthrosis treated with a prosthesis of synovial fluid of domestic production. Medical Council. 2023; 17 (13): 166–174. (In Russ.) https:// doi.org/10.21518/ms2023–256

3. Balabanova R.M., Dubinina T.V. Five-year (2013–2017) trends in the incidence and prevalence of musculoskeletal system diseases among the adult population of Russia. Modern Rheumatology Journal. 2019; 13 (4): 11–17. (In Russ.) https://doi.org/10.14412/1996–7012–2019–4–11–17

4. Polyakova Yu.V., Papichev E. V., Akhverdyan Y. R., Sivordova L. E., Zavodovskii B.V. New Coronavirus infection – direct and indirect impact on patients with diseases of the musculoskeletal system and connective tissue. Modern Problems of Science and Education. 2021; 6: 147–147 (In Russ.) http://doi.org/10.17513/spno.31342

5. Lazebnik LB, Konev Yu V. Chronic pain features in the elderly. Clin Gerontol. 2021; 27 (1–2): 64–68. https://doi.org/10.26347/1607–2499202101–02064–068

6. Polyakova YU.V., Sivordova L. E., Ahverdyan Yu.R., et al. Correction of body weight as an effective treatment for osteoarthritis. Attending Physician. Lvrach.ru. 2015; 4: 32. (In Russ.) https://www.lvrach.ru/2015/04/15436199

7. Matveev R.P., Bragina S.V. Social characteristics of outpatients with knee joint Osteoartrosis. Ekologiya cheloveka (Human Ecology). 2011; 4: 50–5. (In Russ.) https://cyberleninka.ru/article/n/sotsialnaya-harakteristika-ambulatornyh-bolnyh-osteoartrozom-kolennogo-sustava

8. Finageev S.A., Korolik O.D., Polyakova Yu.V., et al. Circulating visfatin/Nampt levels in patients with osteoarthritis and comorbid diseases. Preventive medicine. 2021; 24 (8): 44–48. (In Russ.) https://doi.org/10.17116/profmed20212408144

9. Gur'yanova E.A., Rechapova E. A., Sidyakina E. S. Effectiveness of comprehensive geriatric assessment to improve the quality of life of older people and relieve the burden on their caregivers. Acta Medica Eurasica. 2021; 4: 79–90. (In Russ.) http://doi.org/10.47026/2413–4864–2021–4–79–90

10. Ware J. E., Kosinski M., Keller S. D. SF-36 Physical and Mental Health Summary Scales: A User's Manual. Health Institute, New England Medical Center. Boston: Mass, 1994. 188. https://www.researchgate.net/publication/292390260_SF-36_Physical_and_Mental_Health_Summary_Scales_a_User's_Manual

11. Zborovskaya I.А., Aleksandrov А.V., Aleksandrov V.A., et al. Dynamics of quality-of-life indicators during personalized rehabilitation in patients with Rheumatoid arthritis with Arterial hypertension. Modern Problems of Science and Education. 2021; 6: 146. (In Russ.) http://doi.org/10.17513/spno.31286

12. Clinical recommendations of the Ministry of Health of the Russian Federation. Gonarthrosis. 2021. https://cr.minzdrav.gov.ru/recomend/667

13. Lila A.M., Alekseeva L.I., Taskina E.A., et al. Clinical guidelines (project) for the diagnostics and treatment of primary Osteoarthritis for primary care specialists (General practitioners, therapists). Therapy. 2023; 9, 1 (63): 7–22. (In Russ.) https://doi.org/10.18565/therapy.2023.1.7–22

14. Pham T., Van der Heijde D., Altman R.D., et al. OMERACT-OARSI Initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthritis and Cartilage. 2014; 12 (5): 389–399. http://doi.org/10.1016/j.joca.2004.02.001

15. Lushpaeva Yu.A. A patient with osteoarthritis at an outpatient appointment. Unresolved problems. Lechaschi Vrach (The Attending Physician). 2021; 10 (24): 50–55. (In Russ.) https://doi.org/10.51793/os.2021.24.10.009

16. Sivordova L. E., Polyakova J. V., Papichev E. V., et al. Clinical efficiency and safety of innovative synovial fluid prosthesis in the treatment of gonarthritis. Meditsinskiy sovet. Medical Council. 2022 (21): 127–136. (In Russ.) https://doi.org/10.21518/2079–701x-2022–16–21–127–136