Gender-related differences in clinical presentation of myocardial infarction and levels of laboratory markers assosiated with inflamation and endothelial dysfunction
Abstract
Purpose. To evaluate gender-related differences in clinical presentation of myocardial infarction and the results of an assessment of the laboratory biomarkers level associated with inflammation and endothelial dysfunction, depending on sex. Materials and methods. The study involved 106 patients after myocardial infarction. In addition to the general clinical examination on day 14 and 3 months later, were detected of the following markers in the blood: superoxide dismutase, interleukin-6 and interleukin-10, endothelin-1 by immunoenzyme method, the level of circulating endotheliocytes was determined by flow cytometry, the content of a highly sensitive C-reactive protein and von Willebrand factor antigen with an immuno-turbidimetric method. Results. It was found that among women such risk factors of coronary arteries diseases as age, diabetes mellitus, obesity were more frequent. The disease most often occurred at the background of chronic kidney disease, myocardial infarction more often than in men has led to the development of severe heart failure. Conclusions. In all patients regardless of gender, dysfunction of the endothelium was revealed, but its implementation in women and men was carried out with the participation of various biomarkers.
About the Authors
Z. O. Khushvaktova
North-West Federal Medical Research Centre n.a. V.A. Almazov
Russian Federation
Russian Federation
G. A. Kurharchik
North-West Federal Medical Research Centre n.a. V.A. Almazov
Russian Federation
Russian Federation
L. B. Gaykovaya
North-West Federal Medical Research Centre n.a. V.A. Almazov
Russian Federation
Russian Federation
T. V. Vavilova
North-West Federal Medical Research Centre n.a. V.A. Almazov; North-Western State Medical University n.a. I.I. Mechnikov
Russian Federation
Russian Federation
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Review
For citations:
Khushvaktova Z.O., Kurharchik G.A., Gaykovaya L.B., Vavilova T.V. Gender-related differences in clinical presentation of myocardial infarction and levels of laboratory markers assosiated with inflamation and endothelial dysfunction. Medical alphabet. 2017;2(31):17-21. (In Russ.)
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