Efficacy of bilateral pallidal deep brain stimulation in treatment of patients with segmental and generalized dystonia
Abstract
We investigated 49 patients with medically refractory generalized and segmental primary dystonia. All patients underwent bilateral stereotactic electrode implantation for continuous DBS GPi. Mean follow-up ranged from 1 to 8 years. Following constant DBS GPi, all patients experienced gradual alleviation of movement disorders. Mean clinical improvement at the last follow-up was 64.0 ± 17.7% (BFMDRS, motor subscore). According to GOS, excellent and good results were observed in 88 % of patients. In conclusion, DBS GPi appeared to be an effective and a relatively safe treatment for pharmacoresistant primary dystonia. A significantly better outcome was observed in patients with minor disease duration, elder age of dystonia onset, and minor disease severity.
About the Authors
A. A. Gamaleya
National Scientific and Practical Center for Neurosurgery n.a. N.N. Burdenko
Russian Federation
Russian Federation
A. A. Tomsky
National Scientific and Practical Center for Neurosurgery n.a. N.N. Burdenko
Russian Federation
Russian Federation
A. A. Poddubskaya
National Scientific and Practical Center for Neurosurgery n.a. N.N. Burdenko
Russian Federation
Russian Federation
E. M. Salova
National Scientific and Practical Center for Neurosurgery n.a. N.N. Burdenko
Russian Federation
Russian Federation
A. V. Dekopov
National Scientific and Practical Center for Neurosurgery n.a. N.N. Burdenko
Russian Federation
Russian Federation
E. D. Isagulyan
National Scientific and Practical Center for Neurosurgery n.a. N.N. Burdenko
Russian Federation
Russian Federation
N. V. Fyodorova
Medical Academy for Postgraduate Education
Russian Federation
Russian Federation
S. B. Buklina
National Scientific and Practical Center for Neurosurgery n.a. N.N. Burdenko
Russian Federation
Russian Federation
V. A. Shabalov
National Scientific and Practical Center for Neurosurgery n.a. N.N. Burdenko
Russian Federation
Russian Federation
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For citations:
Gamaleya A.A., Tomsky A.A., Poddubskaya A.A., Salova E.M., Dekopov A.V., Isagulyan E.D., Fyodorova N.V., Buklina S.B., Shabalov V.A. Efficacy of bilateral pallidal deep brain stimulation in treatment of patients with segmental and generalized dystonia. Medical alphabet. 2017;1(2):47-55. (In Russ.)
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