Antibiotic-associated diarrhea in hospital: frequency and prophylaxis
https://doi.org/10.33667/2078-5631-2021-20-35-37
Abstract
The aim. To analyze the prevalence of antibiotic-associated diarrhea (AAD) caused by Clostridium difficile in a hospital setting.
Materials and methods. 93 patients with 3 or more episodes of unformed stool (diarrhea) for two consecutive days or more, developed after the use of antibiotics, were monitored. All patients underwent rapid stool analysis for the presence of Clostridium difficile A and B toxins using the X/pert C. diff toxin A/B test.
Results. Toxins A and/or B of Clostridium difficile were detected in 32 patients (34.4 %). The remaining patients (n = 61; 65.6 %) had idiopathic AAD. The most of the patients who were found to have Clostridium difficile toxins in the feces were in the infarction department, cardiology intensive care and trauma departments, i. e. they had severe diseases associated with reduced immunity and inactivity.
Conclusions. The prevalence of AAD caused by Clostridium difficile in hospital settings is high. It is recommended to prescribe drugs for the correction of disorders of the gastrointestinal microflora from the first day of antibiotic therapy, since this will significantly reduce the prevalence of clinical manifestation of diarrhea associated with Clostridium difficile.
About the Authors
Yu. P. Uspenskiy
Saint Petersburg State Pediatric Medical University; First Saint Petersburg State Medical University n. a. I. P. Pavlov
Russian Federation
Russian Federation
Uspensky Yuri P., DM Sci, professor, head of Dept of Faculty Therapy; professor at Dept of Internal Medicine of Faculty of Dentistry
N. V. Baryshnikova
First Saint Petersburg State Medical University n. a. I. P. Pavlov; Institute for Experimental Medicine
Russian Federation
Russian Federation
Baryshnikova Natalia V., PhD Med, associate professor at Internal Diseases Dept of Stomatological Faculty; researcher
Saint Petersburg
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Review
For citations:
Uspenskiy Yu.P., Baryshnikova N.V. Antibiotic-associated diarrhea in hospital: frequency and prophylaxis. Medical alphabet. 2021;(20):35-37. (In Russ.) https://doi.org/10.33667/2078-5631-2021-20-35-37
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