Distribution and degradation of hyaluronic acid during subdermal administration
https://doi.org/10.33667/2078-5631-2021-9-67-71
Abstract
Hyaluronic acid (HA) is a viscoelastic gel. The substance has a high ability to deform. It also has properties such as plasticity, lift, ease of distribution, and tissue mobilization during facial muscle activity. The aim of the study was to evaluate the safety and effectiveness of HA at the microscopic level. The study was conducted in two stages. In the first stage, the tissue filler was injected bolus-subdermally to rats and rabbits. The second stage involved female volunteers. The drug was also administered to the problem areas on the face. In addition to the histochemical observation, the effectiveness of the procedure on the woman’s face was also evaluated. High safety was demonstrated, as well as an increase in the expression level of collagen and elastin fibers.
About the Authors
S. I. Surkichin
Central State Medical Academy of the Administrative Department of the President of Russia, Moscow
Russian Federation
Russian Federation
S. I. Surkichin, PhD Med, associate prof. at Dept of Dermatovenereology and Cosmetology
S. N. Gres
Peoples’ Friendship University of Russia, Moscow
Russian Federation
Russian Federation
S. N. Gres, assistant prof. at Dept of Public Health, Healthcare and Hygiene
References
1. Michaud T. Rheology of hyaluronic acid and dynamic facial rejuvenation: Topographical specificities. J Cosmet Dermatol. 2018; 17 (5): 736–743. DOI: 10.1111/jocd.12774
2. Sundaram H, Fagien S. Cohesive polydensified matrix hyaluronic acid for fine lines. Plast Reconstr Surg. 2015; 136 (5 Suppl): 149S-163S.
3. Sundaram H, Rohrich RJ, Liew S, et al. Cohesivity of hyaluronic acid fillers: development and clinical implications of a novel assay, pilot validation with a five-point grading scale, and evaluation of six U. S. Food and Drug Administration-approved fillers. Plast Reconstr Surg. 2015; 136 (4): 678–686.
4. La Gatta A, Salzillo R, Catalano C, et al. Hyaluronan-based hydrogels as dermal fillers: the biophysical properties that translate into a “volumetric” effect. PLoS One. 2019; 14 (6): e0218287.
5. Toole BP. Hyaluronan: from extra-cellular glue to pericellularcue. Nat Rev Cancer 2004; 4: 528–39.
6. Kogan G, Soltes L, Stern R, Gemeiner P. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications. Biotechnol Lett 2007; 29: 17–25.
7. Day AJ, Prestwitch GD. Hyaluronan-binding proteins: tying up the giant. J Biol Chem 2008; 277: 4585–8.
8. Frazer J RE, Laurent TC, Laurent UBG. Hyaluronan: its nature, distribution, functions and turn over. J Intern Med 1997; 242: 27–33.
9. Lukhashev ME, Werb Z. ECM signalling: orchestrating cell behaviour and misbehaviour.Trends Cell Biol 1998; 8: 437–41.
10. Volpi N, Schiller J, Stern R, Soltés L. Role, metabolism, chemical modifications and application of hyaluronan. Curr Med Chem 2009; 16: 1718–45.
11. Csoka AB, Frost GI, Stern R. The six hyaluronidase-like genes in the human and mouse genomes. Matrix Biol 2001; 20: 499–508.
12. Noble PW. Hyaluronan and its catabolic products in tissue injury and repair. Matrix Biol 2002; 21: 25–9.
13. Genasetti A, Vigetti D, Viola M, Karousou E, Moretto P, Rizzi M, et al. Hyaluronan and human endothelial cell behavior. Connect Tissue Res 2008; 49: 120–3.
14. Gall Y. Acide hyaluronique: structure, métabolisme et implication dans la cicatrisation. Ann Dermatol Venereol. 2010; 137 Suppl 1: S 30–S 39
Review
For citations:
Surkichin S.I., Gres S.N. Distribution and degradation of hyaluronic acid during subdermal administration. Medical alphabet. 2021;(9):67-71. (In Russ.) https://doi.org/10.33667/2078-5631-2021-9-67-71
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