Possibility of application of ischemic preconditioning in neurological practice
Abstract
Cerebrovascular diseases present the leading cause of mortality and permanent disability. A large number of medicinal and surgical methods of treatment and prevention, many of which showed its high efficiency, were created and introduced in clinical practice. The development of new therapies based on the use of mobilizing own resources of organism is promising. The increased tolerance of tissues to ischemia, that is, is considerably interesting. The method is based on the possibility of increasing the tolerance of the medulla to ischemia due to its reversible episodes of ischemia, which have not led to the development of its structural damage. Results of the analysis of modern researches devoted to the study of the protective effects of ischemic preconditioning in patients with coronary and cerebrovascular diseases are shown. The possibility of clinical application of ischemic preconditioning is considered.
About the Authors
P. R. Kamchatnov
Russian National Research Medical University n.a. N.I. Pirogov
Russian Federation
Russian Federation
B. A. Abusuev
Dagestan State Medical University
Russian Federation
Russian Federation
E. N. Ismail-Zadeh
Dagestan State Medical University
Russian Federation
Russian Federation
K. B. Manysheva
Dagestan State Medical University
Russian Federation
Russian Federation
References
1. Хочачка П., Сомеро Дж. Стратегия биохимической адаптации. Москва. Мир 1977. 398 с.
2. Щербак Н.С., Галагудза М.М., Баранцевич Е.Р. и соавт. Новый способ моделирования обратимой глобальной ишемии головного мозга у крыс. Бюллетень экспериментальной биологии и медицины. 2011; 152; 11: 592-595.
3. Hougaard K., Hjort N., Zeidler D. et al. Remote ischemic preconditioning as an adunct therapy to thrombolysis inpatients with acute ischemic stroke: a randomized trial. Stroke. 2014; 45(1): 159-67.
4. Janoff A. Alterations in lysosomes (intracellular enzymes) during shock: Effects of preconditioning (tolerance) and protective drugs. Int. Anesthesiol. Clin. 1964; 2: 251-269.
5. Koch S., Katsnelson M., Dong C., Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage: a phase Ib study of safety and feasibility. Stroke. 2011; 42: 1387-1391.
6. Meng R., Asmaro K., Meng L. et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012; 79 (18): 1853-61.
7. Meng R., Ding Y., Asmaro K. et al. Ischemic Conditioning Is Safe and Effective for Octo-and Nonagenarians in Stroke Prevention and Treatment. Neurotherapeutics. 2015; 12 (3): 667-77.
8. Siebert G., Gessner B., Klasser M. Energy supply of the central nervous system. Biblthca. Nutr. Dieta. 1986; 38: 1-26.
9. Weih M., Kallenberg K., Bergk A. et al. Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke. 1999; 30 (9): 1851-4.
10. Yamamoto H., Bogousslavsky J., van Melle G. Different predictors of neurological worsening in different causes of stroke. Arch Neurol. 1998; 55: 481-486.
Review
For citations:
Kamchatnov P.R., Abusuev B.A., Ismail-Zadeh E.N., Manysheva K.B. Possibility of application of ischemic preconditioning in neurological practice. Medical alphabet. 2017;1(2):23-27. (In Russ.)
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