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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-18</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Возможность применения в неврологической практике ишемического прекондиционирования</article-title><trans-title-group xml:lang="en"><trans-title>Possibility of application of ischemic preconditioning in neurological practice</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Камчатнов</surname><given-names>П. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamchatnov</surname><given-names>P. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абусуева</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abusuev</surname><given-names>B. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исмаил-Заде</surname><given-names>Э. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ismail-Zadeh</surname><given-names>E. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Манышева</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Manysheva</surname><given-names>K. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian National Research Medical University n.a. N.I. Pirogov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dagestan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>19</day><month>01</month><year>2017</year></pub-date><volume>1</volume><issue>2</issue><issue-title>Неврология и психиатрия</issue-title><fpage>23</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Камчатнов П.Р., Абусуева Б.А., Исмаил-Заде Э.Н., Манышева К.Б., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Камчатнов П.Р., Абусуева Б.А., Исмаил-Заде Э.Н., Манышева К.Б.</copyright-holder><copyright-holder xml:lang="en">Kamchatnov P.R., Abusuev B.A., Ismail-Zadeh E.N., Manysheva K.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/18">https://www.med-alphabet.com/jour/article/view/18</self-uri><abstract><p>Цереброваскулярные заболевания представляют собой ведущую причину летальности и стойкой инвалидизации. Созданы и внедрены в клиническую практику большое число лекарственных и оперативных способов их лечения и профилактики, многие из которых продемонстрировали свою высокую эффективность. Перспективной является разработка новых способов терапии, основанных на использовании мобилизации собственных ресурсов организма. Значительный интерес представляет повышение толерантности тканей к ишемии - ишемическое прекондиционирование (ИПК). В основе данного метода лежит возможность повышения толерантности мозгового вещества к ишемии вследствие перенесенных эпизодов его обратимой ишемии, не приведшей к развитию его структурного повреждения. Представлены результаты анализа современных исследований, посвященных изучению протективного эффекта ИПК у больных с коронарной и цереброваскулярной патологией. Рассматривается возможность клинического применения ИПК.</p></abstract><trans-abstract xml:lang="en"><p>Cerebrovascular diseases present the leading cause of mortality and permanent disability. A large number of medicinal and surgical methods of treatment and prevention, many of which showed its high efficiency, were created and introduced in clinical practice. The development of new therapies based on the use of mobilizing own resources of organism is promising. The increased tolerance of tissues to ischemia, that is, is considerably interesting. The method is based on the possibility of increasing the tolerance of the medulla to ischemia due to its reversible episodes of ischemia, which have not led to the development of its structural damage. Results of the analysis of modern researches devoted to the study of the protective effects of ischemic preconditioning in patients with coronary and cerebrovascular diseases are shown. The possibility of clinical application of ischemic preconditioning is considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемия головного мозга</kwd><kwd>ишемический инсульт</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>транзиторная ишемическая атака</kwd><kwd>ишемическое прекондиционирование</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cerebral ischemia</kwd><kwd>ischemic stroke</kwd><kwd>ischemic heart disease</kwd><kwd>transient ischemic attack</kwd><kwd>ischemic preconditioning</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Хочачка П., Сомеро Дж. Стратегия биохимической адаптации. Москва. Мир 1977. 398 с.</mixed-citation><mixed-citation xml:lang="en">Хочачка П., Сомеро Дж. Стратегия биохимической адаптации. Москва. Мир 1977. 398 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Щербак Н.С., Галагудза М.М., Баранцевич Е.Р. и соавт. Новый способ моделирования обратимой глобальной ишемии головного мозга у крыс. Бюллетень экспериментальной биологии и медицины. 2011; 152; 11: 592-595.</mixed-citation><mixed-citation xml:lang="en">Щербак Н.С., Галагудза М.М., Баранцевич Е.Р. и соавт. Новый способ моделирования обратимой глобальной ишемии головного мозга у крыс. Бюллетень экспериментальной биологии и медицины. 2011; 152; 11: 592-595.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hougaard K., Hjort N., Zeidler D. et al. Remote ischemic preconditioning as an adunct therapy to thrombolysis inpatients with acute ischemic stroke: a randomized trial. Stroke. 2014; 45(1): 159-67.</mixed-citation><mixed-citation xml:lang="en">Hougaard K., Hjort N., Zeidler D. et al. Remote ischemic preconditioning as an adunct therapy to thrombolysis inpatients with acute ischemic stroke: a randomized trial. Stroke. 2014; 45(1): 159-67.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Janoff A. Alterations in lysosomes (intracellular enzymes) during shock: Effects of preconditioning (tolerance) and protective drugs. Int. Anesthesiol. Clin. 1964; 2: 251-269.</mixed-citation><mixed-citation xml:lang="en">Janoff A. Alterations in lysosomes (intracellular enzymes) during shock: Effects of preconditioning (tolerance) and protective drugs. Int. Anesthesiol. Clin. 1964; 2: 251-269.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Koch S., Katsnelson M., Dong C., Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage: a phase Ib study of safety and feasibility. Stroke. 2011; 42: 1387-1391.</mixed-citation><mixed-citation xml:lang="en">Koch S., Katsnelson M., Dong C., Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage: a phase Ib study of safety and feasibility. Stroke. 2011; 42: 1387-1391.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Meng R., Asmaro K., Meng L. et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012; 79 (18): 1853-61.</mixed-citation><mixed-citation xml:lang="en">Meng R., Asmaro K., Meng L. et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012; 79 (18): 1853-61.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Meng R., Ding Y., Asmaro K. et al. Ischemic Conditioning Is Safe and Effective for Octo-and Nonagenarians in Stroke Prevention and Treatment. Neurotherapeutics. 2015; 12 (3): 667-77.</mixed-citation><mixed-citation xml:lang="en">Meng R., Ding Y., Asmaro K. et al. Ischemic Conditioning Is Safe and Effective for Octo-and Nonagenarians in Stroke Prevention and Treatment. Neurotherapeutics. 2015; 12 (3): 667-77.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Siebert G., Gessner B., Klasser M. Energy supply of the central nervous system. Biblthca. Nutr. Dieta. 1986; 38: 1-26.</mixed-citation><mixed-citation xml:lang="en">Siebert G., Gessner B., Klasser M. Energy supply of the central nervous system. Biblthca. Nutr. Dieta. 1986; 38: 1-26.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Weih M., Kallenberg K., Bergk A. et al. Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke. 1999; 30 (9): 1851-4.</mixed-citation><mixed-citation xml:lang="en">Weih M., Kallenberg K., Bergk A. et al. Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain? Stroke. 1999; 30 (9): 1851-4.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto H., Bogousslavsky J., van Melle G. Different predictors of neurological worsening in different causes of stroke. Arch Neurol. 1998; 55: 481-486.</mixed-citation><mixed-citation xml:lang="en">Yamamoto H., Bogousslavsky J., van Melle G. Different predictors of neurological worsening in different causes of stroke. Arch Neurol. 1998; 55: 481-486.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
