Dynamics of blood lipid-phospholipid profile indicators in elderiy patients with stroke

Abstract

Objective. To study dynamics of blood lipid-phospholipid profile indicators in elderly patients with stroke for criteria optimization of differential diagnosis, treatment and prognosis.

Material and methods. Sixty patients, aged from 60 to 74 years with new-onset hemispheric stroke were examined. 34 patients of them were diagnosed with ischemic stroke (IS); 26 patients had intracerebral hemorrhage (ICH). Patient’s status was assessed using the NIHSS, the Rivermead mobility index, the modified Renkin scale, the Barthel ADL index. We measured blood levels of phosphotidylinosits in patients with acute IS and ICH. The percentage absorption of lipid-phospholipid complexes was also studied in the infrared spectrum of blood serum. The control group consisted of 20 healthy individuals.

Results. Dynamics of lipid-phospholipid complexes in blood serum is associated with the type of stroke. The blood levels of phosphotidylinosits in patients with acute IS and ICH were strongly correlated with degree of neurological deficit, levels of daily activity and functional independence (p < 0,05–0,01).

Conclusion. The received data may be important for individualization of diagnostics and therapeutic interventions in elderly patients with acute IS and ICH.