Acute respiratory viral infections are of great socio-economic importance due to their high prevalence and severe consequences. The article presents recommendations for the treatment of various forms of influenza and other acute respiratory viral infections. Considered tactics of patient management, depending on the severity and the presence of complications, determined the indications for hospitalization, discussed the issues of pathogenetic and symptomatic therapy. Immunoprophylaxis is important in reducing the incidence and mortality from influenza. The article describes the indications for vaccination, risk groups, features of modern vaccines.

Viruses that cause acute respiratory infections are currently widespread and are reported worldwide. Among the most dangerous among them are influenza viruses, with a difficult to predict course and the possibility of rapidly developing life-threatening complications that can lead to death.

The purpose of the research work: to analyze the effectiveness and safety of the treatment of community-acquired viral-bacterial pneumonia in hospital patients using only antibacterial therapy as an etiotropic treatment in comparison with the combined use of antibacterial therapy and the antiviral drug Kagocel®.

Materials and methods. An open, prospective comparative study was conducted (from January 1 to December 31, 2018) to study the effectiveness of monotherapy compared with combination therapy with the antiviral drug Kagocel® for 60 patients diagnosed with community-acquired pneumonia who were admitted during the period of an epidemic rise in the incidence of acute respiratory viral infections and influenza. All patients were treated in the infectious ward of the Regional Clinical Hospital No. 2, (Vladivostok, Russia). Patients were divided into 2 groups, 30 people each, comparable in age, gender and timing of admission to the hospital. The age of patients ranged from 18 to 65 years. The first group consisted of patients who received an antibacterial drug (control group) as an etiotropic therapy, the second group — those who received a combination of antibacterial and antiviral (Kagocel®) drugs (experimental group).

Results. In the group of patients receiving both antibacterial and antiviral therapy with Kagocel®, there was a significant reduction in the duration of the febrile period and catarrhal manifestations compared with patients taking only antibiotics as part of etiotropic therapy. An analysis of the data showed that the use of Kagocel® in the treatment of viral-bacterial pneumonia significantly facilitates the patient’s condition during the illness, shortens the duration of the disease, reduces the duration of the main clinical symptoms of pneumonia, namely the duration of intoxication, catarrhal syndromes, and physical changes in the lungs.

Conclusions. The use of the antiviral drug Kagocel® in the treatment of community-acquired viral-bacterial pneumonia leads to a more rapid relief of the main symptoms of the disease and reduces the duration of the disease. Good tolerance of the therapy, the absence of adverse reactions was noted.

Statistics from around the world show a steady increase in morbidity and mortality from chronic obstructive pulmonary disease. Currently, quite a promising direction is to assess the relationship of immunosuppression of the respiratory system and inflammatory response. Imbalance in the immune system often leads to recurrent, sluggish exacerbation of the disease, deterioration of prognosis and quality of life. The duration of the disease is directly related to more severe violations of cellular and humoral immunity. From this perspective, it is promising to assess the effectiveness of immunomodulators in the treatment of chronic obstructive pulmonary disease.

Diverticular disease of the colon is one of the common diseases of the intestine, which is caused by the formation of bag-shaped diverticula in the wall of the colon. The article discusses the clinic, diagnosis, treatment of various clinical forms of diverticular disease. A review of clinical trials of the efficacy of the nonabsorbable antibiotic Rifaximin-alpha is presented. The concept of a microbiome and its functions is given. The article substantiates the appointment of dietary fiber for diverticular disease.

Summary In pregnant women with different clinical options for arterial hypertension, highly selective beta-blockers may be the drugs of choice from the second trimester of pregnancy. The drugs of this group according to the FDA (US Food and Drug Administration) are classified as category C. Their purpose corresponds to the principle of risks and benefits. One of the highly effective and safe drugs in this group is bisoprolol. However, for early detection of the possible negative effects of beta-blockers on the fetus (a newborn), the probability of occurrence of which is extremely low, it is advisable to monitor the vital functions of the fetus (a newborn), the level of glycemia.

The article gives a definition, classification and mechanisms for the development of edema (increased hydrostatic pressure, increased capillary permeability, decreased colloidal osmotic pressure). The main diseases accompanied by edematous syndrome are considered, diagnostic search algorithms are given. The clinic and treatment of edema of the lower extremities due to lymphatic and venous insufficiency are separately discussed. The data of a clinical study of the effectiveness of drugs based on diosmin and hesperidin in the treatment of chronic venous insufficiency are presented.

Psychoemotional stress is a risk factor for cardiovascular diseases, including arterial hypertension and coronary heart disease. Neurohumoral mechanisms are involved in the development of hypertensive reactions to stress. The severity of stress reactions depends on the stress resistance of people. The study of stress resistance is carried out in industrial sectors associated with the impact of professional psycho-emotional stress. Studies in locomotive drivers reveal a high level of cardiovascular disease. Stress helps to reduce vitamin D. Vitamin D deficiency helps reduce stress resistance. Studies conducted among locomotive drivers have revealed a high prevalence of vitamin D deficiency, requiring medical correction.

Binswanger’s disease is a rare one. Its cause is vascular damage to the brain. The article discusses the clinic, diagnosis, treatment of Binswanger’s disease on the example of a clinical case.

The article discusses the clinic, the main systemic manifestations, diagnostic methods for systemic lupus erythematosus. The given clinical case demonstrates the difficulty of managing a patient with pneumonia and systemic lupus erythematosus (SLE). The use of glucocorticosteroids in patients with SLE with developed pneumonia is discussed.