The article presents the results of the evaluation of the clinical efficacy of the herbal preparation Chophytol in the complex therapy of prolonged neonatal jaundice of various etiologies with indirect hyperbilirubinemia and the risk of developing cholestasis syndrome.

The incidence of different gastroenterological diseases (gastroesophageal reflux disease, chronic gastritis, gallstones, gallbladder cancer, non-alcoholic fatty liver disease, non-alcoholic fatty pancreas disease, neoplasms of the colonic mucosa) in obese patients is investigated in a review article. There are the epidemiological dates, the flow characteristics of these pathologies, forecast, mechanisms of influence of the obesity on the pathogenesis of the gastroenterological diseases, the approaches of treatment.

Complex mechanisms of therapy of non-alcoholic fatty liver disease, the role of L-ornithine-L-aspartate in the level of human growth hormone, with physical loads of various intensify, stress, fatigue, alcohol intake and sleep disorders are considered in the article. The results of the study of clinical efficacy of L-orni-thine-L-aspartate in 96 patients with non-alcoholic steatohepatitis are presented.

The article gives up-to-date information about the most frequent, clinical pictures, diagnostics methods, differential diagnostics and treatment pancreatitis during pregnancy.

The article presents a definition of anorexia, features of the questioning and examining the patient, the logic of diagnostics and differential diagnostics. The main pathogenetic variants of anorexia and the tactics of their treatment are analyzed.

The aim of the study: evaluation of liver function abnormalities in patients with chronic acalculous cholecystitis and their correction. Materials and methods: 101 patients with chronic acalculous cholecystitis were examined at the age of 45.47 ± 1.37 years; the comparison group consisted of 30 practically healthy people. Patients underwent a complex study of the organs of the hepatobiliary tract and esophagogastroduodenal zone using laboratory and instrumental diagnostic methods. Results: Transaminase values did not exceed the limits of reference indices; however they were significantly higher than in patients of the comparison group. The level of indices of cholestasis syndrome (alkaline phosphatase, gamma glutamyltranspeptidase, cholesterol) was significantly higher in the patients of the observation group and exceeded the reference values. instrumental diagnostic methods revealed an increase in the V fraction of bile in multifractional duodenal sounding and a slowdown in the excretion of radiopharmaceuticals in dynamic hepatoscintigraphy. To correct the revealed violations to the standard therapy of HNH, the drug ademethionine was added. Conclusions: the use of ademetionine in the complex therapy of patients with chronic acalculous cholecystitis with functional liver disorders had a positive therapeutic effect in the form of improved clinical, laboratory and instrumental indices.

The review article presents modern information on the pathogenesis of the most common functional diseases of the digestive system (functional dyspepsia and irritable bowel syndrome), as well as the combined functional pathology - overlap syndrome. The article describes modern concepts of violations of the interaction between the central nervous system and the enteral nervous system, the role of various mediators in the development of functional disorders, describes the motor activity of the stomach and intestine, the phenomenon of visceral hypersensitivity and the role of genetic factors. A number of associations between pathogenic processes and the development of clinical symptoms of functional diseases were observed. Particular attention is paid to the role of the intestinal microbiota and its metabolites in the development of functional pathology of the gastrointestinal tract, and the biopsychosocial model of functional disorders.

Review. Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal problems worldwide. GERD is frequently associated with respiratory diseases chronic without a causal link can be claimed. The diagnosis and management of this condition is challenging. We review the current dilemma in this area and discuss the latest studies.

The article represents contemporary data on the illness development mechanisms, the main disease manifestation forms and the treatment methods of the alcoholic liver disease. It also covers the disease progression reasons and the main risk factors.