Evaluated serum levels of brain-derived neurotrophic factor (bdnf) in elderly patients with acute ischemic stroke
https://doi.org/10.33667/2078-5631-2019-1-2(377)-48-51
Abstract
Objective. To find relationships between serum levels of BDNF and clinical characteristics of elderly patients with acute ischemic stroke. Material and methods. We measured serum levels of BDNF in elderly patients with acute ischemic stroke (n = 39), in elderly patients with chronic brain ischemia (CBI) (n = 28) and in gender and age matched healthy controls (n = 26). Patient’s status was assessed using the NIHSS, the Rivermead mobility index, the modified Renkin scale, the Barthel ADL index. Results. The serum levels of BDNF were significantly lower in acute ischemic stroke patients (6,585.39 x 10 ng/ml) as compared to patients with CBI (8,449.84 x 10 ng/ml) and healthy controls (16,565.65 x 10 ng/ml) (р < 0.01). The serum levels of BDNF in acute ischemic stroke patients were strongly correlated with degree of neurological deficit, levels of daily activity and functional independence (p < 0.01). The received data may be important for individualization of diagnostics and therapeutic interventions in elderly patients with acute ischemic stroke.
About the Authors
Yu. V. Abramenko
Tver State Medical University
Russian Federation
Russian Federation
T. A. Slyusar
Tver State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Abramenko Yu.V., Slyusar T.A. Evaluated serum levels of brain-derived neurotrophic factor (bdnf) in elderly patients with acute ischemic stroke. Medical alphabet. 2019;1(2):48-51. (In Russ.) https://doi.org/10.33667/2078-5631-2019-1-2(377)-48-51
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