Study of biointegration and biodegradation of collagen matrix on in vivo model under orthotopic implantation conditions

Abstract

The development of effective and safe methods and materials for increasing the volume of soft tissues is an important part of modern experimental implantology and periodontics. Soft tissue repair has long been a field of fundamental and clinical research. The widespread introduction of materials for the restoration of soft tissue volume in surgical dentistiy is primarily due to their aesthetic demand.Currentty, a lot of scaffolds from various biological and synthetic materials are proposed. Collagen materials occupy an important place among them. Collagen is the main glycoproteins of connective tissues. They make up 25 % of all proteins in the human body and provide resistance to stretching. To date, 27 types of collagen have been established. Type I and type III collagen are included in the group of fibrillating collagen and are part of the bone, skin, ligaments and vessels. The extracellular collagen matrix is an extracellular framework and surrounds cells in almost all tissues. Biomaterial is obtained by chemical and biological treatment of tissues of xenogenic origin. It consists of fibrillar proteins (mainly type I collagen and elastin) that provide elastic and durable spatial architectonics. Contains in its composition of biologically active molecules, glycoproteins (fibronectin and laminin), glycosaminoglycans (hyaluronic acid and chondroitin sulfate A), proteoglycans (decorin and heparan-sulfate).