Chronic alcoholic pancreatitis: focus on state ofintestinal digestion
Abstract
The article presents data on the state of intestinal digestion in patients with chronic alcoholic pancreatitis, whose disorders serve as an additional pathogenetic mechanism for the progression of exocrine pancreatic insufficiency in these patients. Aim of the study. To study the state of intestinal digestion in patients with chronic alcoholic pancreatitis. Materials and methods. The state of intestinal hydrolysis was studied in 37 patients with alcoholic pancreatitis based on studies of amylolytic activity of the small intestine mucosa, the activity of enzymes in the membrane stage of intestinal digestion, the regulatory function of intestinal enzymes and the protein content in small intestine mucosa. In 30 patients, the ultrastructure of the intestinal epithelium was studied. Results and discussion. It was noted that in patients with alcoholic pancreatitis there was a violation of both cavitary and membrane intestinal digestion. The latter was associated with low protein supply of small intestine mucosa, weakening of the regulatory function of intestinal enzymes. The morphological substrate of the disturbed intestinal digestion was the destruction of the brush border elements. Сonclusion. Disorder of intracavitary and membrane stages of intestinal digestion can cause the development and progression of symptoms of exocrine pancreatic insufficiency in patients with alcoholic pancreatitis.
About the Authors
E. Yu. Eryomin
Министерство здравоохранения Республики Мордовия
Russian Federation
Russian Federation
O. A. Strokova
National Research Mordovian State University n.a. N. P. Ogarev
Russian Federation
Russian Federation
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For citations:
Eryomin E.Yu., Strokova O.A. Chronic alcoholic pancreatitis: focus on state ofintestinal digestion. Medical alphabet. 2018;3(30):18-21. (In Russ.)
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