LPS-adsorber in patients with septic shock

20 patients with gram-negative sepsis were enrolled in the study. The criteria for including patients into the study were as follows: clinical signs of septic shock, procalcitonin blood concentration more than 2 ng/ml. The patients received from 1 to 6 hemoperfusion procedures applying LPS-adsorber Duration of each procedure was 2 hours. The following values were determined in the patients before and after each hemoperfusion procedure: the values of IL-4, IL-6, IL-8, IL-10, IL-18 in serum and washout from LPS-adsorber; concentrations of LPS in serum LPS-adsorber were measured by LAL-test and modified micro gel clot test. The decrease in the level of LPS was accompanied by the normalization of clinical and laboratory indicators. In particular, in the group of surviving patients there was a significant increase in mean arterial pressure, a decrease in body temperature and a decrease in the catecholamine load and the PCT level. LPS-adsorber (Alteco) is able to eliminate from the bloodstream not only LPS, but excess cytokines. The obtained data testify to the prospects of further randomized studies of the efficacy of LPS-adsorbers in patients with sepsis and septic shock to clarify the indications for their use.

LPS-адсорбер Alteco, sepsis, septic shock, Alteco LPS adsorber, LPS, interleukins

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