Study of liposomal form of alpha-lipoic acid effect on human hemostatic system
Abstract
The study of the effect of the liposomal form of α-lipoic acid on the human blood coagulation system. There was no significant effect of phosphatidylcholine liposomes containing and not containing а-lipoic acid on the plasma link of haemostasis. it is shown that the liposomal form of α-lipoic acid at concentrations of 0.2-0.4 mg/ml dose-dependent inhibits platelet aggregation in the platelet-rich human blood plasma induced by arachidonic acid, and prevents the reduction of platelet granularity.
About the Authors
V. A. Shchelkonogov
Russian National Research Medical University n. a. N. I. Pirogov; MIREA - Russian Technological University
Russian Federation
Russian Federation
K. S. Savras
Russian National Research Medical University n. a. N. I. Pirogov
Russian Federation
Russian Federation
K. N. Zhigalova
Russian National Research Medical University n. a. N. I. Pirogov
Russian Federation
Russian Federation
A. V. Chekanov
Russian National Research Medical University n. a. N. I. Pirogov
Russian Federation
Russian Federation
O. A. Baranova
Russian National Research Medical University n. a. N. I. Pirogov
Russian Federation
Russian Federation
K. D. Kazarinov
Fryazino Branch of the Institute of Radio Engineering and Electronics n. a. V. A. Kotelnikov
Russian Federation
Russian Federation
Г. Сорокоумова
ФГБОУ ВО «МИРЭА - Российский технологический университет» Минобрнауки России
Russian Federation
Russian Federation
Н. Шастина
ФГБОУ ВО «МИРЭА - Российский технологический университет» Минобрнауки России
Russian Federation
Russian Federation
V. P. Mudrov
ФГБУ «9-й лечебно-диагностический центр» Минобороны России
Russian Federation
Russian Federation
E. Yu. Solovyova
Russian National Research Medical University n. a. N. I. Pirogov
Russian Federation
Russian Federation
A. I. Fedin
Russian National Research Medical University n. a. N. I. Pirogov
Russian Federation
Russian Federation
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Review
For citations:
Shchelkonogov V.A., Savras K.S., Zhigalova K.N., Chekanov A.V., Baranova O.A., Kazarinov K.D., , , Mudrov V.P., Solovyova E.Yu., Fedin A.I. Study of liposomal form of alpha-lipoic acid effect on human hemostatic system. Medical alphabet. 2018;3(26):52-57. (In Russ.)
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