Study of polymorphous marker’s (+1267A>G) association with risk of hypertension in patients with long-term stress

Abstract

Hypertension is a socially significant disease. The effects of psychological stress is one of the risk factors for hypertension. The expression of the heat shock protein gene 70 (HSP70) and its polymorphic marker + 1267A>G (rs754888705) in the HSP70 gene was studied in 72 women, exposed to prolonged stress due to the oncological disease of the child. The control group included 63 women without long-term stress factors. The expression of the HSP70 gene in women with episodes of high blood pressure (BP) was studied. In women under the influence of prolonged psychological stress an increase level of the HSP70 gene s expression was revealed. The statistically significant prevalence of the A allele in the gene HSP70-2 J267A>G (rs754888705) was revealed in the group of mothers with stress and BP elevation; prevalence of the allele G noted in the control group.