Oral collagen therapy in the correction of involutional skin changes: analysis of pharmacokinetics and clinical efficacy
https://doi.org/10.33667/2078-5631-2026-3-107-109
Abstract
Collagen is the main structural protein of connective tissue, determining the biomechanical properties and integrity of the skin. This paper presents an analysis of current data on the physiological role of collagen in the dermis and describes the molecular mechanisms of chronological and photoaging. Particular attention is paid to the role of matrix metalloproteinases (MMPs) in the process of collagen scaffold fragmentation. Current data on the effectiveness of oral hydrolyzed collagen for maintaining healthy skin and other connective tissues are reviewed. Particular attention is paid to analyzing the feasibility of using complex supplements containing collagen types I, II, and III. A critical review of the absorption mechanisms and action of bioactive peptides, clinical trial data, and meta-analyses is provided, and common myths associated with the separate use of different types of collagen are addressed.
About the Authors
L. S. Kruglova
Central State Medical Academy of the Administrative Department of the President of Russian Federation
Russian Federation
Russian Federation
Kruglova Larisa S., Dr Med Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, rector
Moscow
N. V. Gryazeva
Central State Medical Academy of the Administrative Department of the President of Russian Federation
Russian Federation
Russian Federation
Gryazeva Natalya V., Dr Med Sci (habil.), professor at Dept of Dermatovenereology and Cosmetology
S. I. Surkichin
Polyclinic No. 2 of the Administrative Department of the President of Russian Federation
Russian Federation
Russian Federation
Surkichin Sergey I., Dr Med Sci (habil.), head of Dept of Dermatovenereology
Moscow
R. A. Shaikhalieva
Health and Beauty Center "Romanov”
Russian Federation
Russian Federation
Shaikhalieva Rita A., cosmetologist
Moscow
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Review
For citations:
Kruglova L.S., Gryazeva N.V., Surkichin S.I., Shaikhalieva R.A. Oral collagen therapy in the correction of involutional skin changes: analysis of pharmacokinetics and clinical efficacy. Medical alphabet. 2026;(3):107-109. (In Russ.) https://doi.org/10.33667/2078-5631-2026-3-107-109
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