medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2026-3-107-109medalphabet-4962Research ArticleСтатьиПероральная коллагенотерапия в коррекции инволютивных изменений кожи: анализ фармакокинетики и клинической эффективностиOral collagen therapy in the correction of involutional skin changes: analysis of pharmacokinetics and clinical efficacyhttps://orcid.org/0000-0002-5044-5265КругловаЛ. С.KruglovaL. S.

Круглова Лариса Сергеевна, д.м.н., профессор, зав. кафедрой дерматовенерологии и косметологии, ректор

Москва

Kruglova Larisa S., Dr Med Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, rector

Moscow 

kruglovals@mail.ruhttps://orcid.org/0000-0003-3437-5233ГрязеваН. В.GryazevaN. V.

Грязева Наталья Владимировна, д.м.н., профессор кафедры дерматовенерологии и косметологии

Москва

Gryazeva Natalya V., Dr Med Sci (habil.), professor at Dept of Dermatovenereology and Cosmetology

tynrik@yandex.ruhttps://orcid.org/0000-0003-0521-0333СуркичинС. И.SurkichinS. I.

Суркичин Сергей Иванович, д.м.н., заведующий отделением дерматовенерологии

Москва

Surkichin Sergey I., Dr Med Sci (habil.), head of Dept of Dermatovenereology 

Moscow 

surkichunsi24@mail.ruhttps://orcid.org/0009-0006-8451-1183ШайхалиеваР. А.ShaikhalievaR. A.

Шайхалиева Рита Абдрахмановна, врач косметолог 

Москва

Shaikhalieva Rita A., cosmetologist 

Moscow 

ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy of the Administrative Department of the President of Russian FederationRussian FederationФГБУ «Поликлиника № 2» Управления делами Президента Российской ФедерацииРоссияPolyclinic No. 2 of the Administrative Department of the President of Russian FederationRussian FederationЦентр здоровья и красоты «Романов»РоссияHealth and Beauty Center "Romanov”Russian Federation20261404202603Дерматология (1)107109Copyright © Круглова Л.С., Грязева Н.В., Суркичин С.И., Шайхалиева Р.А., 20262026Круглова Л.С., Грязева Н.В., Суркичин С.И., Шайхалиева Р.А.Kruglova L.S., Gryazeva N.V., Surkichin S.I., Shaikhalieva R.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4962

Коллаген является основным структурным белком соединительной ткани, определяющим биомеханические свойства кожи и ее целостность. В настоящей работе представлен анализ современных данных о физиологической роли коллагена в дерме, а также описаны молекулярные механизмы хронологического и фотостарения. Особое внимание уделено роли матриксных металлопротеиназ (ММП) в процессе фрагментации коллагенового каркаса. Рассматриваются современные данные об эффективности перорального приема гидролизованного коллагена для поддержания здоровья кожи и других соединительных тканей. Особое внимание уделено анализу целесообразности применения комплексных добавок, содержащих коллаген I, II и III типов. Проводится критический обзор механизмов абсорбции и действия биоактивных пептидов, данных клинических исследований и метаанализов, а также разбираются распространенные мифы, связанные с раздельным приемом разных типов коллагена.

Collagen is the main structural protein of connective tissue, determining the biomechanical properties and integrity of the skin. This paper presents an analysis of current data on the physiological role of collagen in the dermis and describes the molecular mechanisms of chronological and photoaging. Particular attention is paid to the role of matrix metalloproteinases (MMPs) in the process of collagen scaffold fragmentation. Current data on the effectiveness of oral hydrolyzed collagen for maintaining healthy skin and other connective tissues are reviewed. Particular attention is paid to analyzing the feasibility of using complex supplements containing collagen types I, II, and III. A critical review of the absorption mechanisms and action of bioactive peptides, clinical trial data, and meta-analyses is provided, and common myths associated with the separate use of different types of collagen are addressed.

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The authors declare that there are no conflicts of interest present.