Complications of migraine
https://doi.org/10.33667/2078-5631-2025-32-7-11
Abstract
Migraine is a common and benign disease that does not shorten the life and does not lead to disability of patients. Migraine complications are extremely rare and in most cases occur in patients suffering from migraine with aura, with the exception of status migrainosus. The International Classification of headaches in 2018 identifies as complications: status migrainosus, persistent aura without infarction, migrainous infarction and migraine aura-triggered seizure; the appendix discusses visual snow and migraine aura status. The article is of an overview nature, which presents diagnostic criteria, features of differential diagnosis, as well as currently available theoretical approaches to migraine complications. Treatment of status migrainosus, clinical features and therapy of persistent aura without infarction, diagnosis and differential diagnosis of migrainous infarction and ischemic stroke of other causes, differential diagnosis of migraine aura status with organic neurological syndromes, as well as clinical features, pathogenesis and comorbidity of «visual snow» described in the article, are important for the clinical practice of neurologists.
About the Author
E. G. Filatova
Sechenov First Moscow State Medical University (Sechenov University); Clinic of Headache and Autonomic Disorders named after Academician Alexander Wein
Russian Federation
Russian Federation
Filatova Elena G., Dr Med Sci (habil.), professor at Dept of Nervous Diseases, Institute of Professional Education; neurologist
Moscow
References
1. Rasmussen B. K., Jensen R., Schroll M., Olesen J. Epidemiology of headache in a general population – a prevalence study. J Clin Epidemiol. 1991; 44: 1147–1157.
2. Ayzenberg I., Katsarava Z., Sborowski A. et al. The prevalence of primary headache disorders in Russia: A countrywide survey. Cephalalgia. 2012; 32 (5): 373–381.
3. Lebedeva E. R., Kobzeva N. R., Gilev D. V., Olesen E. Analysis of the quality of diagnosis and treatment of primary headaches in various social groups of the Ural region. Neurology, neuropsychiatry, psychosomatics. 2015; 1: 19–26. (In Russ.).
4. Vos T, Abajobir AA, Abate KH, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017; 390: 1211–59.
5. The International Classification of Headache Disorders, 3rd edition (ICHD‑3). Cephalalgia. 2018; 38 (1): 1–211.
6. Amelin A. V. and others. Efficacy of zolmitriptan nasal spray in adult patients with migraine. Medical advice. 2023;17; 13: 65–71. (In Russ.).
7. David Dodick 1, Jan Brandes, Arthur Elkind, Ninan Mathew, Lawrence Rodichok. Speed of onset, efficacy and tolerability of zolmitriptan nasal spray in the acute treatment of migraine: a randomised, double-blind, placebo-controlled study CNS Drugs. 2005; 19 (2): 125–36.
8. Migraine in adults. Clinical recommendations of the Ministry of Health of the Russian Federation 2022. (In Russ.).
9. Chen WT, Lin YY, Fuh JL, Hämäläinen MS, Ko YC, Wang SJ. Sustained visual cortex hyperexcitability in migraine with persistent visual aura. Brain. 2011; 134 (8): 2387–2395. DOI: 10.1093/brain/awr157. [PubMed] [CrossRef] [Google Scholar]
10. de Almeida RF, Leão IA, Gomes JB, da Silva AA Jr, Teixeira AL. Migraine with persistent visual aura: response to furosemide. Clinics. 2009; 64: 375–376. [PMC free article] [PubMed] [Google Scholar]
11. Gryglas A., Smigiel R. Migraine and Stroke: What’s the Link? What to Do? Curr Neurol Neurosci Rep. 2017; 17: 22. DOI: 10.1007/s11910-017-0729-y
12. Borończyk et al. The Journal of Headache and Pain. 2025; 26: 39. https://doi.org/10.1186/s10194–025–01973-w
13. Ischemic stroke and transient ischemic attack. Clinical recommendations of the Ministry of Health of the Russian Federation 2022. (In Russ.).
14. Kremenchugskaya M. R., Oknin V. Yu., Sokolov P. L., Filatova E. G. Features of the formation of bioelectric activity of the brain in paroxysmal and chronic forms of primary headaches. Journal of Neurology and Psychiatry named after S. S. Korsakov. 2003; 103 (10): 38–42. (In Russ.).
15. Azimova Yu.E., Tabeeva G. R. Migraine and epilepsy. Epilepsy and paroxysmal states. 2009; 1: 21–25. (In Russ.).
16. Mazurenko E. V., Selitsky M. M., Boyko A. V. Posterior reversible encephalopathy syndrome – Literature review and own clinical observation. Medical News. 2023; 2: 29–33. (In Russ.).
17. Kalashnikova L. A., Konovalov R. N., Dobrynina L. A. Reversible cerebral vasospasm syndrome and ischemic stroke. S. S. Korsakov Journal of Neurology and Psychiatry. Special editions. 2023; 123 (12–2): 17–23. (In Russ.).
18. Kalashnikova L. A. Dissection of internal carotid and vertebral arteries: clinic, diagnosis and treatment. Neurology, neuropsychiatry, psychosomatics. 2013; 2; 40–44. (In Russ.).
19. Klein A., Schankin C. J., Visual Snow Syndrome as a Network Disorder: A Systematic Review. Front Neurol. 2021 Oct 4; 12: 724072. DOI: 10.3389/fneur.2021.724072. eCollection 2021
Review
For citations:
Filatova E.G. Complications of migraine. Medical alphabet. 2025;(32):7-11. (In Russ.) https://doi.org/10.33667/2078-5631-2025-32-7-11
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