Preview

Medical alphabet

Advanced search

Pathogenetically directed action of dermatocosmetics in acne

https://doi.org/10.33667/2078-5631-2025-23-40-42

Abstract

The article describes the main etiopathogenetic factors of acne development, including hormonal mechanisms. Modern advances in dermatology and endocrinology make it possible to develop new, more effective and safer treatment methods based on the molecular and clinical analysis of each patient. A personalized approach, integration of data on hormonal status, lipid profile and microbiota opens up prospects for individualizing therapy, increasing its effectiveness and improving the prognosis of the disease.

About the Authors

L. S. Kruglova
Central State Medical Academy of the Administrative Department of the President of Russian Federation
Russian Federation

Kruglova Larisa S., DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, vice‑rector for Academic Affairs

Moscow 



N. V. Gryazeva
Central State Medical Academy of the Administrative Department of the President of Russian Federation
Russian Federation

Gryazeva Natalya V., DM Sci (habil.), professor at Dept of Dermatovenereology and Cosmetology

Moscow



References

1. Zouboulis, C.C. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions / C.C. Zouboulis, E. Jourdan, M. Picardo // J Eur Acad Dermatol Venereol. 2014; 28 (5): 527–532.

2. Leyden, J. The evolving role of Propionibacterium acnes in acne / J. Leyden // Semin Cutan Med Surg. 2001; 20 (3): 139–143.

3. Atsugi, T. Holocrine secretion occurs outside the tight junction barrier in multicellular glands: Lessons from claudin 1–deficient mice / T. Atsugi, M. Yokouchi, T. Hirano [et al.] // Journal of Investigative Dermatology. 2020; 140 (2): 298–308.

4. Mattii, M. Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells / M. Mattii, M. Lovászi, N. Garzorz [et al.] // British Journal of Dermatology. 2018; 178 (3): 722–730.

5. Krause, K. Corticotropin releasing hormone skin signaling is receptor mediated and is predominant in the sebaceous glands / K. Krause, A. Schnitger, S. Fimmel [et al.] // Hormone and metabolic research. 200; 39 (2): 166–170.

6. Zouboulis, C.C. Sexual hormones in human skin / C.C. Zouboulis, W.C. Chen, M.J. Thornton [et al.] // Horm Metab Res. 2007; 39 (2): 85–95.

7. Mirdamadi, Y. Insulin and insulin like growth factor 1 can modulate the phosphoinositide 3 kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro / Y. Mirdamadi, A. Thielitz, A. Wiede [et al.] // Mol Cell Endocrinol. 2015; 415: 32–44.

8. Thiboutot, D. Changes in the management of acne: 2009–2019 / D. Thiboutot, B. Dréno, V. Sanders [et al.] // J Am Acad Dermatol. 2020; 82 (5): 1268–1269.

9. Margolis, D. Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross sectional and prospective cohort study / D. Margolis // Arch Dermatol. 2012; 148 (3): 326–332.

10. Mirdamadi, Y. Effects of isotretinoin on the phosphoinositide 3 kinase/Akt/FoxO1 pathway and molecular functions of SZ95 sebocytes / Y. Mirdamadi, A. Thielitz, A. Wiede [et al.] // J. Clin. Exp. Dermatol. Res. 2017; 8: 1000399.

11. Sanam, M. Desogestrel+ ethinylestradiol versus levonorg estrel+ ethinylestradiol / M. Sanam, O. Ziba // Saudi Med J. 2011; 32 (1): 23–26.

12. Araviiskaia, E. The role of topical dermocosmetics in acne vulgaris / E. Araviiskaia, B. Dreno // J Eur Acad Dermatol Venereol. 2016; 30: 926–935.


Review

For citations:


Kruglova L.S., Gryazeva N.V. Pathogenetically directed action of dermatocosmetics in acne. Medical alphabet. 2025;1(23):40-42. (In Russ.) https://doi.org/10.33667/2078-5631-2025-23-40-42

Views: 9


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)