medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2025-23-40-42medalphabet-4647Research ArticleСтатьиПатогенетически направленное действие дерматокосметики при акнеPathogenetically directed action of dermatocosmetics in acnehttps://orcid.org/0000-0002-5044-5265КругловаЛ. С.KruglovaL. S.

Круглова Лариса Сергеевна, д.м.н., профессор, заведующая кафедрой дерматовенерологии и косметологии, проректор по учебной работе

Москва

Kruglova Larisa S., DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology, vice‑rector for Academic Affairs

Moscow 

kruglovals@mail.ruhttps://orcid.org/0000-0003-3437-5233ГрязеваН. В.GryazevaN. V.

Грязева Наталья Владимировна, д.м.н., профессор кафедры дерматовенерологии и косметологии

Москва 

Gryazeva Natalya V., DM Sci (habil.), professor at Dept of Dermatovenereology and Cosmetology

Moscow

tynrik@yandex.ruФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy of the Administrative Department of the President of Russian FederationRussian Federation202511112025123Дерматология (2)4042Copyright © Круглова Л.С., Грязева Н.В., 20252025Круглова Л.С., Грязева Н.В.Kruglova L.S., Gryazeva N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4647

В статье описаны основные этиопатогенетические факторы развития акне, включая гормональные механизмы. Современные достижения в области дерматологии и эндокринологии позволяют разрабатывать новые, более эффективные и безопасные методы лечения, основанные на молекулярном и клиническом анализе каждого пациента. Персонализированный подход, интеграция данных о гормональном статусе, липидном профиле и микробиоте открывают перспективы для индивидуализации терапии, повышения ее результативности и улучшения прогноза заболевания.

The article describes the main etiopathogenetic factors of acne development, including hormonal mechanisms. Modern advances in dermatology and endocrinology make it possible to develop new, more effective and safer treatment methods based on the molecular and clinical analysis of each patient. A personalized approach, integration of data on hormonal status, lipid profile and microbiota opens up prospects for individualizing therapy, increasing its effectiveness and improving the prognosis of the disease.

акнепатогенезгормональные нарушениядерматокосметикаacnepathogenesishormonal disordersdermatocosmeticsReferencesZouboulis, C.C. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions / C.C. Zouboulis, E. Jourdan, M. Picardo // J Eur Acad Dermatol Venereol. 2014; 28 (5): 527–532.Zouboulis, C.C. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions / C.C. Zouboulis, E. Jourdan, M. Picardo // J Eur Acad Dermatol Venereol. 2014; 28 (5): 527–532.Leyden, J. The evolving role of Propionibacterium acnes in acne / J. Leyden // Semin Cutan Med Surg. 2001; 20 (3): 139–143.Leyden, J. The evolving role of Propionibacterium acnes in acne / J. Leyden // Semin Cutan Med Surg. 2001; 20 (3): 139–143.Atsugi, T. Holocrine secretion occurs outside the tight junction barrier in multicellular glands: Lessons from claudin 1–deficient mice / T. Atsugi, M. Yokouchi, T. Hirano [et al.] // Journal of Investigative Dermatology. 2020; 140 (2): 298–308.Atsugi, T. Holocrine secretion occurs outside the tight junction barrier in multicellular glands: Lessons from claudin 1–deficient mice / T. Atsugi, M. Yokouchi, T. Hirano [et al.] // Journal of Investigative Dermatology. 2020; 140 (2): 298–308.Mattii, M. Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells / M. Mattii, M. Lovászi, N. Garzorz [et al.] // British Journal of Dermatology. 2018; 178 (3): 722–730.Mattii, M. Sebocytes contribute to skin inflammation by promoting the differentiation of T helper 17 cells / M. Mattii, M. Lovászi, N. Garzorz [et al.] // British Journal of Dermatology. 2018; 178 (3): 722–730.Krause, K. Corticotropin releasing hormone skin signaling is receptor mediated and is predominant in the sebaceous glands / K. Krause, A. Schnitger, S. Fimmel [et al.] // Hormone and metabolic research. 200; 39 (2): 166–170.Krause, K. Corticotropin releasing hormone skin signaling is receptor mediated and is predominant in the sebaceous glands / K. Krause, A. Schnitger, S. Fimmel [et al.] // Hormone and metabolic research. 200; 39 (2): 166–170.Zouboulis, C.C. Sexual hormones in human skin / C.C. Zouboulis, W.C. Chen, M.J. Thornton [et al.] // Horm Metab Res. 2007; 39 (2): 85–95.Zouboulis, C.C. Sexual hormones in human skin / C.C. Zouboulis, W.C. Chen, M.J. Thornton [et al.] // Horm Metab Res. 2007; 39 (2): 85–95.Mirdamadi, Y. Insulin and insulin like growth factor 1 can modulate the phosphoinositide 3 kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro / Y. Mirdamadi, A. Thielitz, A. Wiede [et al.] // Mol Cell Endocrinol. 2015; 415: 32–44.Mirdamadi, Y. Insulin and insulin like growth factor 1 can modulate the phosphoinositide 3 kinase/Akt/FoxO1 pathway in SZ95 sebocytes in vitro / Y. Mirdamadi, A. Thielitz, A. Wiede [et al.] // Mol Cell Endocrinol. 2015; 415: 32–44.Thiboutot, D. Changes in the management of acne: 2009–2019 / D. Thiboutot, B. Dréno, V. Sanders [et al.] // J Am Acad Dermatol. 2020; 82 (5): 1268–1269.Thiboutot, D. Changes in the management of acne: 2009–2019 / D. Thiboutot, B. Dréno, V. Sanders [et al.] // J Am Acad Dermatol. 2020; 82 (5): 1268–1269.Margolis, D. Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross sectional and prospective cohort study / D. Margolis // Arch Dermatol. 2012; 148 (3): 326–332.Margolis, D. Association of pharyngitis with oral antibiotic use for the treatment of acne: a cross sectional and prospective cohort study / D. Margolis // Arch Dermatol. 2012; 148 (3): 326–332.Mirdamadi, Y. Effects of isotretinoin on the phosphoinositide 3 kinase/Akt/FoxO1 pathway and molecular functions of SZ95 sebocytes / Y. Mirdamadi, A. Thielitz, A. Wiede [et al.] // J. Clin. Exp. Dermatol. Res. 2017; 8: 1000399.Mirdamadi, Y. Effects of isotretinoin on the phosphoinositide 3 kinase/Akt/FoxO1 pathway and molecular functions of SZ95 sebocytes / Y. Mirdamadi, A. Thielitz, A. Wiede [et al.] // J. Clin. Exp. Dermatol. Res. 2017; 8: 1000399.Sanam, M. Desogestrel+ ethinylestradiol versus levonorg estrel+ ethinylestradiol / M. Sanam, O. Ziba // Saudi Med J. 2011; 32 (1): 23–26.Sanam, M. Desogestrel+ ethinylestradiol versus levonorg estrel+ ethinylestradiol / M. Sanam, O. Ziba // Saudi Med J. 2011; 32 (1): 23–26.Araviiskaia, E. The role of topical dermocosmetics in acne vulgaris / E. Araviiskaia, B. Dreno // J Eur Acad Dermatol Venereol. 2016; 30: 926–935.Araviiskaia, E. The role of topical dermocosmetics in acne vulgaris / E. Araviiskaia, B. Dreno // J Eur Acad Dermatol Venereol. 2016; 30: 926–935.

The authors declare that there are no conflicts of interest present.