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Radiation therapy in the combined/complex treatment of patients with breast cancer I–IIA, in stages after subcutaneous/skin-preserving mastectomies with simultaneous reconstruction
https://doi.org/10.33667/2078-5631-2024-32-55-59
Abstract
Background. Currently, after subcutaneous/skin-preserving mastectomies with simultaneous reconstruction in cancer of stages I–II, the need for radiation therapy is debatable, especially in the presence of favorable subtypes or when complete clinical regression is achieved after neoadjuvant polychemotherapy.
Materials and methods. A retrospective non-randomized study was conducted, which included 1135 breast cancer patients who received treatment at the P.A. Herzen Moscow State Medical Institute from 2014 to 2023, in all patients the surgical stage included subcutaneous/skinpreserving mastectomies with simultaneous reconstruction. The patients were divided into 2 groups – with and without radiation therapy.
Results. Relapses were analyzed by groups depending on the clinical and morphological features of tumors, with a detailed analysis of the data obtained.
Conclusion. Among patients I–IIA, In the stages of breast cancer after PME/CME with reconstruction included in the study, the risk of recurrence over 5 years was 4.3± 0.1% of cases. The recurrence in the group with radiation therapy was 2.5±0.6%, without radiation therapy 6.9±1.2% (p0.05), thus radiation therapy reduces the risk of recurrence by 4.4%. In our study, the following criteria were identified for the appointment of radiation therapy in the postoperative period: resection margin R1, luminal/non-luminal NONR2 positive type, rN1.
About the Authors
E. A. Rasskazova
Moscow Research Institute n.a. P.A. Herzen – a Branch of the National Medical Research Centre of Radiology
Russian Federation
Russian Federation
Rasskazova Elena A., PhD Med, researcher at Dept of Oncology and Reconstructive Plastic Surgery of the Breast and Skin
Moscow
A. D. Zikiryakhodjaev
Moscow Research Institute n.a. P.A. Herzen – a Branch of the National Medical Research Centre of Radiology ; I.M. Sechenov First Moscow State Medical University (Sechenov University) ; Peoples’ Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Zikiryakhodjaev Azizjon D., DM Sci (habil.), professor, head of Dept of Oncology and Reconstructive Plastic Surgery of the Breast and Skin, professor at Dept of Oncology, professor at Dept of Oncology
Moscow
A. D. Kaprin
Moscow Research Institute n.a. P.A. Herzen – a Branch of the National Medical Research Centre of Radiology ; I.M. Sechenov First Moscow State Medical University (Sechenov University) ; Peoples’ Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Kaprin Andrey D., academician of the Russian Academy of Sciences, DM Sci (habil.), professor, director
Moscow
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Review
For citations:
Rasskazova E.A., Zikiryakhodjaev A.D., Kaprin A.D. Radiation therapy in the combined/complex treatment of patients with breast cancer I–IIA, in stages after subcutaneous/skin-preserving mastectomies with simultaneous reconstruction. Medical alphabet. 2024;(32):55-59. (In Russ.) https://doi.org/10.33667/2078-5631-2024-32-55-59
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