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Clinical Case of Acute Analgesic Nephropathy in a 14-Year-Old Child
N. V. Teplova,
S. S. Postnikov,
J. D. Tramova,
E. K. Petrosyan,
M. N. Kostyleva,
A. N. Grazzianskaya,
L. B. Belousova,
D. Yu. Dalakyan https://doi.org/10.33667/2078-5631-2023-23-62-66
Abstract
Medications are responsible for more than a quarter of cases of acute kidney failure (AKF) in both outpatient and hospital practice. This is often due to underestimating the safety of prescribed drugs, the over-the-counter availability of medications, insufficient justification for prescriptions, and uncontrolled use. In 70–90 % of cases, acute drug-induced kidney damage presents as acute tubulointerstitial nephritis (ATIN), with a mortality rate of around 10 %. This article presents a case of acute kidney injury in a teenage girl following the use of sodium metamizole during the postoperative period. The timely application of two hemodialysis sessions helped avoid disaster, and subsequent monitoring of the patient (enalapril 2.5 mg twice daily, levocarnitine 20 % 1 teaspoon twice daily, dietary restrictions) over nearly two years showed slow recovery of kidney function, which indicates the severe nature of the kidney damage.
About the Authors
N. V. Teplova
Department of Clinical Pharmacology named after Yu. B. Belousov, Institute of Clinical Medicine, N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Teplova Natalia V., DM Sci (habil.), professor, head of Dept of Clinical Pharmacology, Institute of Clinical Medicine
Moscow
S. S. Postnikov
Department of Clinical Pharmacology named after Yu. B. Belousov, Institute of Clinical Medicine, N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Postnikov Sergey S., DM Sci (habil.), professor at Department of Clinical Pharmacology, Institute of Clinical Medicine
Moscow
J. D. Tramova
Russian Children’s Clinical Hospital, branch of N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Tramova Zhanetta D., physician of Dept of Reconstructive and Thoracic Surgery
Moscow
E. K. Petrosyan
Department of Clinical Pharmacology named after Yu. B. Belousov, Institute of Clinical Medicine, N. I. Pirogov Russian National Research Medical University; Russian Children’s Clinical Hospital, branch of N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Petrosyan Edita K., DM Sci (habil.), professor at Dept of Hospital Pediatrics named after V. A. Tabolin, Institute of Maternity and Childhood, head of Nephrology Dept
Moscow
M. N. Kostyleva
Department of Clinical Pharmacology named after Yu. B. Belousov, Institute of Clinical Medicine, N. I. Pirogov Russian National Research Medical University; Russian Children’s Clinical Hospital, branch of N. I. Pirogov Russian National Research Medical
University
Russian Federation
Russian Federation
Kostyleva Maria N., PhD Med, associate professor at Dept of Clinical Pharmacology, Institute of Clinical Medicine, head the Dept of Clinical Pharmacology
Moscow
A. N. Grazzianskaya
Department of Clinical Pharmacology named after Yu. B. Belousov, Institute of Clinical Medicine, N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Gratsianskaya Anna N., PhD Med, associate professor at Dept of Clinical Pharmacology, Institute of Clinical Medicine
Moscow
L. B. Belousova
Department of Clinical Pharmacology named after Yu. B. Belousov, Institute of Clinical Medicine, N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Belousova Lyudmila B., 6th-year student of the Faculty of Pediatrics
Moscow
D. Yu. Dalakyan
Department of Clinical Pharmacology named after Yu. B. Belousov, Institute of Clinical Medicine, N. I. Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Dalakyan Daria Yu., 6th year student of the pediatric faculty
Moscow
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Review
For citations:
Teplova N.V., Postnikov S.S., Tramova J.D., Petrosyan E.K., Kostyleva M.N., Grazzianskaya A.N., Belousova L.B., Dalakyan D.Yu. Clinical Case of Acute Analgesic Nephropathy in a 14-Year-Old Child. Medical alphabet. 2024;(23):62-66. (In Russ.) https://doi.org/10.33667/2078-5631-2023-23-62-66
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