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The effect of Sedimentum Lateritium of the 16th century reveals the role of renal dysfunction in the comorbidity of diseases of the 21st century
https://doi.org/10.33667/2078-5631-2024-4-50-55
Abstract
For the purpose of studying the diagnostic effectiveness of the Sedimentum lateritium phenomenon, known since the XVI century, on the basis of a formed laboratory model for registering the formation of sediment in urine during cooling – a cold urine sample (CPM), by methods of dynamic light scattering and Z-potential measurement, the mechanism of formation of “cryogel” in urine during polymerization of pathological isoforms of uromodulin (UMD) was verified, characteristic of patients with urolithiasis.
As a result of the analysis of a “non-core” cohort of individuals with cardiological and pulmonological profiles, the described sol-gel phase transition was detected with a frequency of 21–31 %, respectively. A hypothesis has been put forward about comorbidity due to the metabolism of various UMD isoforms: in urolithiasis, as a result of violations of apical posttranslational processing of oligo-polymer isoforms of UMD and, as a result of exposure to xenobiotics and damage to intracellular metabolism with destruction of the basement membrane and the release of monomeric isoforms of UMD into the interstitium of the kidneys, initiating inflammation and subsequent fibrosis with increased intrarenal pressure, reducing GFR, i. e. the development of CKD.
Conclusion: the described biophysical technology can be considered as a screening method for preclinical verification of the cascade of metabolic consequences along the “cardio-hepatorenal” continuum that forms the comorbidity of diseases in the population.
About the Authors
A. V. Iakovleva
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Iakovleva Anastasiia V., head of laboratory, clinical laboratory diagnostics physician
St. Petersburg
K. T. Momynaliev
Russian Scientific and Research Institute for Medical Engineering
Russian Federation
Russian Federation
Momynaliev Kuvat T., Dr Bio Sci, associate professor, assistant general director
Moscow
M. G. Zalesky
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Zaleskiу Mikhail G., PhD Bio Sci
St. Petersburg
N. A. Verlov
Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Centre “Kurchatov Institute”
Russian Federation
Russian Federation
Verlov Nikolay A., PhD Bio Sci, head of Resource Center of Dept of Molecular and Radiation Biophysics
Leningrad region, Gatchina
I. I. Skibo
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Skibo Irina I., clinical laboratory diagnostics physician of the highest category, assistant of Dept of Clinical Laboratory Diagnostics with a Course in Molecular Medicine
St. Petersburg
V. L. Emanuel
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Emanuel Vladimir L., DM Sci (habil.), professor, head of Dept of Clinical Laboratory Diagnostics with a Course in Molecular Medicine
St. Petersburg
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Review
For citations:
Iakovleva A.V., Momynaliev K.T., Zalesky M.G., Verlov N.A., Skibo I.I., Emanuel V.L. The effect of Sedimentum Lateritium of the 16th century reveals the role of renal dysfunction in the comorbidity of diseases of the 21st century. Medical alphabet. 2024;(4):50-55. (In Russ.) https://doi.org/10.33667/2078-5631-2024-4-50-55
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