Distinctive features of multidimensional relationships of hypercalcemia associated with dynamics of bone metabolism markers

Abstract

The use of the method of visualization of multidimensional connections, as an auxiliary method in the analysis of the obtained laboratory data, significantly increases their informativeness. At the same time, it becomes possible to identify the leading factors that influence the overall structure of the ratios of the indicators of the selected panel and their «relationship» with each other. This paper presents the results of a discussion of the connections obtained using the method of visualization of multidimensional connections inside the panel of electrolyte ratios, demonstrating the possibility of identifying functional relationships of bone metabolism and hypocalcemia. At the same time, the authors, including, provide individual observations in which, against the background of normal calcium indicators, relationship are recorded indicating a marked decrease in its functional activity. The authors suggest that a highly significant negative (correlation coefficient) effect of calcium in the integral panel of the electrolyte ratio at its normal values reveal the manifestation of intense individual adaptive adjustment in the network of factors supporting the physiological values of the ion. However, it prolonged predominance can lead to the occurrence of certain disorders, including bone metabolism. It is concluded that the definition of a complex of multidimensional relationships in individual cases will allow not only to personalize the differential diagnosis of hypocalcemia, but also to choose targets for targeted therapy and subsequent monitoring of the effectiveness of the treatment.