Minolexin® in complex therapy of papulo-pustular acne of moderate severity (results of own research)

Abstract

The aim of the study. A retrospective analysis of the results of complex therapy of moderate papulo-pustular acne with minocycline 50 mg per day orally and 15 % azelaic acid gel topically under natural ultraviolet irradiation.

Materials and methods. In a retrospective study, data from outpatient charts and the results of studying the morpho-functional parameters of the facial skin of 61 people (31 acne patients and 30 healthy individuals) were analyzed. Patients received oral minocycline (Minolexin®) 50 mg per day for 6 weeks and topically 15 % azelaic acid gel 2 times a day for 12 weeks in the period from April to September.

Results and discussion. The therapy was effective: clinical cure occurred in 90.3 % (n = 28), clinical remission – in 9.7 % (n = 3) patients. Rapid regression of papulo-pustules was achieved through the use of minocycline, which had antibacterial and anti-inflammatory effects. After treatment, elevated values of sebumetry, skin relief, pore size, and pigmentation were normalized in the group of patients with acne, due to the action of a topical gel, as well as the absence of photosensitizing effect in minocycline. Systemic and local adverse events registered in outpatient records were of a temporary nature and did not require discontinuation of therapy.