Analysis of C-reactive protein and lactoferrin levels in patients with myocardial infarction with chronic obstructive pulmonary disease depending on presence of complications
https://doi.org/10.33667/2078-5631-2023-16-30-33
Abstract
Purpose. To analyze the levels of C-reactive protein (CRP) and lactoferrin (LF) in patients with myocardial infarction (MI) with chronic obstructive pulmonary disease (COPD) depending on the presence of acute MI complications.
Materials and methods. In total were examined 325 patients with MI: 195 patients with acute MI + COPD and 130 MI patients without COPD and 110 healthy somatic subjects. Complications of acute MI were observed in 84 (43.1 %) MI + COPD patients and in 32 (24.6 %) MI patients without COPD.
Results of the study. The level of inflammatory markers we studied was elevated in all observation groups relative to controls. In MI + COPD patients and in MI patients without COPD the level of highly sensitive CRP was statistically significantly higher in the presence of acute period complications. LF levels did not depend on the presence of complications in any of the observation groups.
Conclusions. Increased inflammatory markers in MI patients without COPD and in MI + COPD groups indicate the significance of the inflammatory component in the pathogenesis of MI. In patients with MI + COPD the severity of systemic inflammation is maximal. CRP is informative as an indicator of inflammatory response in MI. The highest CRP level was observed in patients with complicated MI.
About the Author
T. V. Prokofieva
Astrakhan State Medical University
Russian Federation
Russian Federation
Prokofieva Tatiana V., PhD Med, associate professor at Dept of Internal Medicine of Pediatric Faculty
Astrakhan
References
1. Polunina O. S., Uklistaya T. A., Polunina E. A. Prevalence of comorbid combination of chronic obstructive pulmonary disease and cardiovascular pathology according to retrospective analysis. Astrakhan Medical Journal. 2018; 13 (2): 90–96.
2. Andersson Ch., Hansen P. W., Steffensen I. E., Andreasen Ch., Weeke P. E., Køber L., Gislason G. H., Torp-Pedersen Ch. Mortality associated with cardiovascular drugs in patients with chronic obstructive pulmonary disease and right-sided heart failure: A danish nationwide registry-based study. European Journal of Internal Medicine. 2019; 63: 56–61. DOI: 10.1016/j.ejim.2019.02.014.
3. Chaulin A. M., Grigoryeva Y. V., Dulyakov D. V. Comorbidity: Chronic obstructive pulmonary disease and cardiovascular disease. Practical Medicine. 2020; 18 (1): 26–31.
4. Shishkina Ye.A., Khlynova O. V., Tuev A. V., Novikova I. A., Nekrutenko L. A. Possible prediction of recurrent myocardial infarction in patients of working age. Russian Journal of Cardiology. 2020; 25 (8): 3909. DOI: 10.15829/1560–4071–2020–3909.
5. Zafiraki V. K., Kosmacheva E. D., Mirzaev S. G., Shulzhenko L. V., Ramazanov D. M., Omarov A. A., Imetova J. B., Pershukov I. V. Chronic obstructive pulmonary disease in patients with coronary heart disease worsens the long-term prognosis after percutaneous coronary interventions. Cardiology. 2021; 61 (11): 24–32. DOI: 10.18087/cardio.2021.11.n1820.
6. Strelnikova M. V., Sineglazova A. V. Interrelation of inflammation and oxidative stress with the severity of acute coronary syndrome in men. Modern problems of science and education. 2020; 3. URL: https://science-education.ru/ru/article/view?id = 29803 (date of accession: 13.05.2023).
7. Afanasyeva A. N. Demyanov S. V., Repin A. N., Afanasyev S. A., Markov V. A., Evtushenko V. A. Laboratory evaluation of endogenous intoxication in patients with myocardial infarction. Russian Journal of Cardiology. 2007; 12 (3): 36–40.
8. Provotorov V. M., Budnevsky A. V., Semenkova G. G., Shishkina E. S. Pro-inflammatory cytokines in combination of CHD and CHD. Clinical Medicine. 2015; 2: 5–9.
9. Khlynova O. V., Shishkina E. A., Abgaryan N. I. Cytokine status of patients with myocardial infarction as a possible predictor of the degree of coronary atherosclerosis. Cardiovascular Therapy and Prevention. 2020; 19 (3): 155–160. DOI: 10.15829/1728–8800–2020–2316.
10. Belokoneva K. P. Prognostic value of lactoferrin and cytokines in the assessment of adverse outcomes in patients with Q-wave myocardial infarction who died of acute heart failure. Cardiology: News, opinions, and teaching. 2016; 10 (3): 75–82.
11. The fourth universal definition of myocardial infarction. 2018; URL: https://russjcardiol.elpub.ru/jour/article/viewFile/3259/2531
12. Acute myocardial infarction with ST segment elevation of the electrocardiogram. Clinical guidelines. Ministry of Health of the Russian Federation, Society of Specialists in Emergency Cardiology. 2016; 56 p.
13. Diagnostics and treatment of patients with acute coronary syndrome without an electrocardiogram ST segment elevation. Clinical guidelines. Ministry of Health of the Russian Federation, Society of Specialists in Emergency Cardiology. 2015; 95 p.
Review
For citations:
Prokofieva T.V. Analysis of C-reactive protein and lactoferrin levels in patients with myocardial infarction with chronic obstructive pulmonary disease depending on presence of complications. Medical alphabet. 2023;(16):30-33. (In Russ.) https://doi.org/10.33667/2078-5631-2023-16-30-33
Views:
133
Email this article 