Difficulties in differential diagnosis of myasthenia gravis (clinical case)
https://doi.org/10.33667/2078-5631-2022-32-13-16
Abstract
Myasthenia gravis is a rare autoimmune disease, the clinical picture of myasthenia gravis is manifested by fluctuating weakness, pathological muscle fatigue and it is difficult for clinicians to diagnose it appropriately. The article presents a clinical case of misdiagnosis of late-onset myasthenia gravis, it provides a chronology of the development of symptoms of the disease and an analysis of the difficulties of differential diagnosis. Despite the typical manifestations of myasthenia gravis, the patient did not receive propriate pathogenetic therapy for a long time, while he was prescribed drugs that block neuromuscular conduction and worsen the course of the disease.
About the Authors
S. V. LobzinRussian Federation
Lobzin Sergei V., DM Sci (habil.), professor, head of Dept of Neurology n. a. academician S. N. Davidenkov. eLibrary SPIN: 7274–6327
St. Peterburg
A. R. Alibekov
Russian Federation
Alibekov Ailer R., postgraduate student of Dept of Neurology n. a. academician S. N. Davidenkov, neurologist. eLibrary SPIN: 1112–9540
St. Peterburg
Vsevolozhsk
E. G. Klocheva
Russian Federation
Klocheva Elena G., DM Sci (habil.), professor at Dept of Neurology n. a. academician S. N. Davidenkov. eLibrary SPIN: 6220–5349
St. Peterburg
A. L. Sharapova
Russian Federation
Sharapova Anna L., neurologist at Dept of Neurology
Velikiy Novgorod
V. V. Goldobin
Russian Federation
Goldobin Vitaliy V., DM Sci (habil.), professor, head of Dept of Neurology n. a. academician S. N. Davidenkov. eLibrary SPIN: 4344–5782
St. Peterburg
References
1. Myasthenia gravis: diagnosis and treatment. Ed. S.V. Lobzin. St. Petersburg: SpecLit, 2015. 160 p.
2. Sanadze A.G. Myasthenia gravis and myasthenic syndromes. M.: GEOTAR-Media, 2019. 256 p.
3. Alekseeva T.M., Kryuchkova V.V., Stuchevskaya T.R., Khalmurzina A.N. Epidemiologic studies of myasthenia gravis: literature review. Nervno-myshechnye bolezni = Neuromuscular Diseases 2018; 8 (3): 12–18.
4. Breiner A., Widdifield J., Katzberg H.D., et al. Epidemiology of myasthenia gravis in Ontario, Canada. Neuromuscul Disord. 2016; 26 (1): 41–46. DOI: 10.1016/j.nmd.2015.10.009.
5. Martinka I., Fulova M., Spalekova M., Spalek P. Epidemiology of myasthenia gravis in Slovakia in the years 1977–2015. Neuroepidemiology. 2018; 50 (3–4): 153–159. DOI: 10.1159/000487886.
6. Maddison P., Ambrose P.A., Sadalage G., et al. Prospective study of the incidence of myasthenia gravis in the East Midlands of England. Neuroepidemiology. 2019; 53 (1–2): 93–991–7. DOI: 10.1159/000500268.
7. Engstrom J. Myasthenia gravis: diagnostic mimics. Seminars in Neurology. 2004; 24 (2): 141–147. DOI: 10.1055/s-2004–830903. PMID: 15257510.
8. Al-Asmi A., Nandhagopal R., Jacob P.C., Gujjar A. Misdiagnosis of myasthenia gravis and subsequent clinical implication. A case report and review of literature. Sultan Qaboos Univ Med J. 2012; 12 (1): 103–108. DOI: 10.12816/0003095. PMID: 22375266.
9. Akkaya Ö.F., Şahin H.A., Şenel A., et al. Brain stem lesion mimicking myasthenia gravis. Clinical Neurology and Neurosurgery. 2005; 107 (3): 246–248. DOI: 10.1016/j.clineuro.2004.06.007.
10. Basiri K., Ansari B., Okhovat A.A. Life-threatening misdiagnosis of bulbar onset myasthenia gravis as a motor neuron disease: How much can one rely on exaggerated deep tendon reflexes. Adv Biomed Res. 2015; 4 (58). DOI: 10.4103/2277–9175.151874.
11. Shcherbakova N. I., Piradov M.A., Pavlova E. M., et al. The causes, risk factors and predictors of myasthenia gravis crisis. Nevrologicheskiy zhurnal = Neurological Journal. 2013; 18 (2): 11–19.
12. Kon'kova, D. Yu. Early diagnostics and differential diagnostics of myasthenia gravis: Methodical manual. Blagoveshchensk. 2016. 21 p.
13. Khurshilov A.B. Clinical and epidemiological characteristics of myasthenia gravis in the Leningrad region [dissertation]. St. Petersburg, 2017. 116 p.
14. Khalmurzina A.N. Clinical, diagnostic and therapeutic aspects of myasthenia gravis with onset in old age [dissertation]. St. Petersburg, 2020. 114 p.
15. Fisman K.G., Kott H.S. Myasthenia gravis mimicking stroke in elderly patients. Mayo Clin Proc. 1998; 73 (11): 1077–8. DOI: 10.4065/73.11.1077.
16. Libman R., Benson R., Einberg K. Myasthenia mimicking vertebrobasilar stroke. Journal of Neurology. 2002; 249 (11): 1512–1514. DOI: 10.1007/s00415–002–0858–2.
17. Aarli J.A. Myasthenia gravis in the elderly: Is it different? Ann NY Acad Sci. 2008; 1132: 238–243. DOI: 10.1196/annals.1405.040.
Review
For citations:
Lobzin S.V., Alibekov A.R., Klocheva E.G., Sharapova A.L., Goldobin V.V. Difficulties in differential diagnosis of myasthenia gravis (clinical case). Medical alphabet. 2022;1(32):13-16. (In Russ.) https://doi.org/10.33667/2078-5631-2022-32-13-16