Chronic viral infection and toxic epidermal necrolisis (Lyell´s syndrome)
A. B. Krivosheev,
T. V. Ermachenko,
P. P. Khavin,
K. V. Zakharov,
A. A. Okrugina,
I. A. Krivosheeva,
I. V. Ammosova https://doi.org/10.33667/2078-5631-2022-28-15-18
Abstract
Two cases of toxic epidermal necrolysis (Lyell's syndrome) are described. The introduction discusses the relevance of this problem. Emphasis is placed on the differential diagnosis of Lyell's syndrome with Stevens-Johnson syndrome, since both syndromes are difficult to distinguish in the debut. As differential diagnostic criteria, it is recommended to take into account the presence of Nikolsky's symptom and the area of involvement in the pathological process of the skin more than 30%. In the manifestation of Lyell's syndrome, the role of genetic predisposition is not excluded. The presented observations indicate that the first clinical symptoms are identical. In both cases, the disease was triggered by medications first used. The common background was viral infection: long-term chronic HCV-infection in combination with herpes zoster and HIV-infection without antiretroviral therapy. Our observations expand our understanding of the likely predisposing factors of Lyell's syndrome, which can include acute and long-term chronic viral infections.
About the Authors
A. B. Krivosheev
Novosibirsk State Medical University
Russian Federation
Russian Federation
Krivosheev Alexander B., DM Sci (habil.), professor at Dept of Faculty Therapy n.a. professor G.D. Zalessky
Novosibirsk
T. V. Ermachenko
City Clinical Hospital No. 1
Russian Federation
Russian Federation
Ermacheko Tamara V., physician of superior expert category, pulmologist, head of Pulmonology Dept
Novosibirsk
P. P. Khavin
City Clinical Hospital No. 1
Russian Federation
Russian Federation
Khavin Pavel P., PhD Med, physician of superior expert category, pulmologist
Novosibirsk
K. V. Zakharov
City Clinical Hospital No. 1
Russian Federation
Russian Federation
Zakharov Kirill V., pulmologist of Pulmonology Dept
Novosibirsk
A. A. Okrugina
City Clinical Hospital No. 1
Russian Federation
Russian Federation
Okrugina Anastasia A., pulmologist of Pulmonology Dept
Novosibirsk
I. A. Krivosheeva
City Clinical Hospital No. 1
Russian Federation
Russian Federation
Krivosheeva Inga A., PhD Med, physician of superior expert category, honored doctor of the Russian Federation
Novosibirsk
I. V. Ammosova
City Clinical Hospital No. 1
Russian Federation
Russian Federation
Ammosova Irina V., physician of superior expert category, pulmologist, resident physician of Pulmonology Dept
Novosibirsk
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For citations:
Krivosheev A.B., Ermachenko T.V., Khavin P.P., Zakharov K.V., Okrugina A.A., Krivosheeva I.A., Ammosova I.V. Chronic viral infection and toxic epidermal necrolisis (Lyell´s syndrome). Medical alphabet. 2022;1(28):15-18. (In Russ.) https://doi.org/10.33667/2078-5631-2022-28-15-18
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