Herbal remedies as a way to treat benign pathology of the mammary gland
https://doi.org/10.33667/2078-5631-2022-24-31-37
Abstract
Violations of neuroendocrine homeostasis under stressful conditions against the background of increased estrogen presence in tissues can become a stimulus for the development of benign breast pathology, both in the form of pain syndrome – cyclic mastalgia, less often non-cyclic mastalgia, and in the form of benign breast dysplasia (DMDM), one of symptoms of which can also be mastalgia. The diagnosis and treatment of benign breast pathology has been the responsibility of a gynecologist since 2009. This is correct, the pathogenetic commonality of pain syndromes and diseases associated with abnormal proliferation is obvious in gynecological practice. The goal of treating mastalgia is to improve the quality of life of the patient, but if mastalgia has a morphological substrate in the form of DMDM, then in addition to pain relief. It is necessary to provide for curbing the progression of the disease to reduce the risk of developing breast cancer. Hormonal treatment has limited possibilities here and the search for therapeutic concepts is usually carried out in the direction of therapy with plant-derived molecules that can influence the metabolism of estrogens in tissues. In addition to this lever of influence on the abnormal proliferation processes abnormal proliferation in the mammary gland, there are other targets involved in the pathophysiology of abnormal proliferation and pain in the mammary gland, in particular, oxidative stress, the immune system, etc. In this regard, molecules with pleiotropic biological effects are of interest, such as resveratrol, simultaneously exhibiting the properties of phytoestrogen, antioxidant, insulin sensitizer, etc. The combination of resveratrol and indole-3-carbinol for the treatment of cyclic mastalgia and DMDM seems to be an attractive option for improving the quality of life and preventing malignant neoplasms.
About the Author
I. V. Kuznetsova
Medical Corporation ‘RHANA’
Russian Federation
Russian Federation
Kuznetsova Irina V., DM Sci (habil.), professor
Moscow
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Kuznetsova I.V. Herbal remedies as a way to treat benign pathology of the mammary gland. Medical alphabet. 2022;(24):31-37. (In Russ.) https://doi.org/10.33667/2078-5631-2022-24-31-37
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