Evaluation of the proliferative activity of cell cultures on nanostructured coatings for dental implants

The success of implantation treatment largely depends on osseointegration – a stable connection of bone tissue cells with the implant surface. One of the key technical factors on which successful osseointegration depends is the biocompatible surface of the implant.

Materials and methods. The authors investigated three series of coatings on prototypes (samples) of titanium implants for biological compatibility: titanium dioxide (TiO₂) films obtained by plasma activated atomic layer deposition (PEALD); titanium dioxide (TiO₂) films obtained by sol-gel method; diamond-like carbon (DLC) films. Primary cultures of MSCs – mesenchymal stromal cells of rat adipose tissue were used to study proliferative activity.

Results. A total of 30 samples were examined, samples made of titanium grade VT6 without coating served as a control. Samples, TiO₂ ALD 25 nm, DLC 100 nm and DLC 200 nm, on which cellular elements showed significantly high levels of proliferative activity showed high biological compatibility.

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