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Use of biologically active dietary supplements containing Omega-3 fatty acids at patients with arterial hypertension and hyperlipidemia

Abstract

In the paper we present results of the research where influence of omega-3 polyunsaturated acid on lipid metabolism in patients with arterial hypertension and hyperlipidemia. The aim of the study was to estimate efficacy and safety of differently drug doses of the biologically active dietary supplements Doppel Herz aktiv® Omega-3 at patients with arterial hypertension f-ff and hyperlipidemia. fncrease of level of triglycerides more than 1.7 mmol/l and less than 4.0 mmol/l as criterion of a hyperlipidemia was used. Thereby 90 patients (average age 61.2 ± 8.3 years, males 26.7% and females 73.3 %) with arterial hypertension and hyperlipidemia were analyzed. All patients were on base antihypertensive therapy and have been divided into 3 groups. Doppel Herz aktiv® Omega-3 was added to the first and the second group of patients, the daily dose was 800 and 1,600 mg OD accordingly. Third group received traditional therapy of arterial hypertension. There were about 30 patients in each group. After 12 weeks of the treatment with Doppel Herz aktiv® Omega-3 a maximal decrease of the level of triglycerides was revealed in patients of the second group, effective dose was equal to 1,600 mg. At the same time the most significant effect was at patients with the level of triglycerides in the range from 2.3 mmol/l up to 4.0 mmol/l. The tolerance of Omega-3 was satisfactory, adverse event (dyspepsia) were non-serious and not required its cancellation.

About the Authors

Zh. M. Sizova
First Moscow State Medical University n.a. I.M. Sechenov
Russian Federation


V. L. Zakharova
First Moscow State Medical University n.a. I.M. Sechenov
Russian Federation


N. I. Lapidus
First Moscow State Medical University n.a. I.M. Sechenov
Russian Federation


E. V. Shikh
First Moscow State Medical University n.a. I.M. Sechenov; Clinical Pharmacology Branch of Scientific Centre for Biomedical Technologies
Russian Federation


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Review

For citations:


Sizova Zh.M., Zakharova V.L., Lapidus N.I., Shikh E.V. Use of biologically active dietary supplements containing Omega-3 fatty acids at patients with arterial hypertension and hyperlipidemia. Medical alphabet. 2017;2(31):10-16. (In Russ.)

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ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)