Morphological changes in pancreas in postoperative hypothyroidism in experiment

Abstract

The work was done on experimental material. A model of postoperative hypothyroidism was obtained by thyroidectomy on 57 male rats. The operation was performed under general anesthesia. In the postoperative period, the behavior of rats was observed. Laboratory animals are withdrawn from the experiment after 7, 14, 21, 28, 35 and 45 days. With hypothyroidism, edema, hemodynamic disturbances, dystrophic and destructive changes are observed in the pancreas. Protein hydropic and balloon dystrophy of exocrinocytes, necrosis of the pancreatic parenchyma with the formation of cavities is noted. Edema of the islets of Langengars. In the stroma of the pancreas, focal lymphocytic infiltrates are determined. Intralobular and interlobular ducts are dilated. The epithelium of the ducts is desquamated into the lumen. In the ducts, stagnation of the secret is noted. The main substance of the connective tissue breaks down with the accumulation of glycosaminoglycans. The first signs of hypothyroidism were detected on the 14th day. A detailed picture of hypothyroidism was detected on the 28th day. By the end of the experiment on the 45th day in the parenchyma of the gland.