Neurological aspects of anxiety disorders
https://doi.org/10.33667/2078-5631-2022-10-7-11
Abstract
The article presents an overview of scientific publications devoted to the study of the problem of anxiety disorders. The authors present various views on the neurobiological mechanisms of the pathogenesis of these disorders, consider the main somatic, neurological and cognitive disorders characteristic of anxiety disorders. Also considered are modern approaches to the pharmacological treatment of anxiety disorders and the main methods of psychotherapeutic correction used in their treatment.
About the Authors
L. S. Chutko
Institute of Human Brain n.a. N. P. Bekhtereva
Russian Federation
Russian Federation
Chutko Leonid S., DM Sci (habil.), professor, head of Laboratory for Correction of Mental Development and Adaptation, head of Centre for Behavioral Neurology
Saint Petersburg
E. A. Yakovenko
Institute of Human Brain n.a. N. P. Bekhtereva
Russian Federation
Russian Federation
Yakovenko E.A., PhD Bio, researcher
Saint Petersburg
S. Yu. Surushkina
Institute of Human Brain n.a. N. P. Bekhtereva
Russian Federation
Russian Federation
Surushkina S. Yu., PhD Med, researcher, neurologist
Saint Petersburg
D. V. Cherednichenko
Institute of Human Brain n.a. N. P. Bekhtereva
Russian Federation
Russian Federation
Cherednichenko D.V., PhD Med, first deputy director
Saint Petersburg
References
1. Bandelow B., Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues Clin Neurosci. 2015; 17 (3) P. 327–335. DOI: 10.31887/DCNS.2015.17.3/bbandelow.
2. Shah S.M.A, Mohammad D., Qureshi M.F.H, Abbas M.Z., Aleem S. Prevalence, Psychological Responses and Associated Correlates of Depression, Anxiety and Stress in a Global Population, During the Coronavirus Disease (COVID-19) Pandemic. Community Ment Health J. 2021; 57 (1) P. 101–110. DOI: 10.1007/s10597–020–00728-y.
3. Santabárbara J., Lasheras I., Lipnicki D.M., Bueno-Notivol J., Pérez-Moreno M., López-Antón R., De la Cámara C., Lobo A., Gracia-García P. Prevalence of anxiety in the COVID-19 pandemic: An updated meta-analysis of community-based studies. Prog Neuropsychopharmacol Biol Psychiatry. 2021; 109 P. 110207. DOI: 10.1016/j.pnpbp.2020.110207.
4. Shamrey V.K. Pathomorphosis of neurotic disorders in military personnel. Military Medical Journal. 2010; 331 (1). P. 29–34.
5. Vasilyeva A.V. Protracted forms of neurotic disorders – the current state of the problem. Bulletin of Neurology, Psychiatry and Neurosurgery. 2011; 8. P. 35–41.
6. May R. The meaning of anxiety. M.: Class; 2001.
7. Lieb R., Witchen G.U. Anxiety disorders. Clinical Psychology. Under ed. M. Perret and W. Baumann. SPb.: Peter; 2003.
8. Kierkegaard S. Fear and Trembling. Moscow: Cultural Revolution; 2010.
9. Daviu N., Bruchas M. R., Moghaddam B., Sandi C., Beyeler A. Neurobiological links between stress and anxiety. Neurobiol Stress. 2019; 11. P. 100191. DOI: 10.1016/j.ynstr.2019.100191.
10. Etkin A., Prater K. E., Schatzberg A. F., Menon V., Greicius M. D. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Arch Gen Psychiatry. 2009; 66 (12) P. 1361–1372. DOI: 10.1001/archgenpsychiatry.2009.104.
11. Makovac E., Meeten F., Watson D.R., Herman A., Garfinkel S.N., D Critchley H., Ottaviani C. Alterations in Amygdala-Prefrontal Functional Connectivity Account for Excessive Worry and Autonomic Dysregulation in Generalized Anxiety Disorder. Biol Psychiatry. 2016; 80 (10) P. 786–795. DOI: 10.1016/j.biopsych.2015.10.013.
12. Maron E., Nutt D. Biological markers of generalized anxiety disorder. Dialogues Clin Neurosci. 2017; 19 (2) P. 147–158. DOI: 10.31887/DCNS.2017.19.2/dnutt.
13. Etkin A., Schatzberg A.F. Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. Am J Psychiatry. 2011; 168 (9) P. 968–978. DOI: 10.1176/appi.ajp.2011.10091290.
14. Beyeler A., Chang C.J., Silvestre M., Lévêque C., Namburi P., Wildes C.P., Tye K.M. Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala. Cell Rep. 2018; 22 (4) P. 905–918. DOI: 10.1016/j.celrep.2017.12.097.
15. Li J., Xia Y., Cheng X., Li S. Fear of Uncertainty Makes You More Anxious? Effect of Intolerance of Uncertainty on College Students' Social Anxiety: A Moderated Mediation Model. Front Psychol. 2020; 11. P. 565107. DOI: 10.3389/fpsyg.2020.565107.
16. Delvecchio G., Stanley J.A., Altamura A.C., Brambilla P. Metabolic alterations in generalised anxiety disorder: a review of proton magnetic resonance spectroscopic studies. Epidemiol Psychiatr Sci. 2017; 26 P. 587–595.
17. Madonna D., Delvecchio G., Soares J.C., Brambilla P. Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review. Braz J Psychiatry. 2019; 41 (4) P. 336–362. DOI: 10.1590/1516–4446–2018–0108.
18. McNaughton N., Gray J.A. Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety. J Affect Disord. 2000; 61 (3) P. 161–176. DOI: 10.1016/s0165–0327(00)00344-x.
19. Starostina E.G. Anxiety and anxiety disorders in the practice of a cardiologist. Cardiovascular therapy and prevention. 2006; 5 (3). P. 111–120.
20. Kociunas R. Fundamentals of psychological counseling. M.: Academic Project; 1999.
21. Voznesenskaya T.G. Generalized anxiety disorder: Differential diagnosis and treatment. Neurology, Neuropsychiatry, Psychosomatics. 2013; 2. P. 18–22.
22. Wittchen H. Generalized anxiety disorder: prevalence, burden, and cost to society. Depress Anxiety. 2002; 16 (4) P. 162–171. DOI: 10.1002/da.10065.
23. Chutko L.S., Surushkina S. Yu., Yakovenko E.A., Nikishena I.S., Anisimova T.I., Bondarchuk Yu.L. Cognitive and emotional disorders in patients with chronic phobic anxiety disorders. Therapeutic Archive. 2014; 12. P. 61–65.
24. Chutko L.S. Anxiety disorders in general medical practice. ELBI-SPB; 2010.
25. Merikangas K.R., Angst J., Isler H. Migraine and psychopathology. Results of the Zurich cohort study of young adults. Arch Gen Psychiatry. 1990; 47 (9) P. 849–853. DOI: 10.1001/archpsyc.1990.01810210057008.
26. Senaratne R., Van Ameringen M., Mancini C., Patterson B., Bennett M. The prevalence of migraine headaches in an anxiety disorders clinic sample. CNS Neurosci Ther. 2010; 16 (2) P. 76–82. DOI: 10.1111/j.1755–5949.2009.00103.x.
27. Mercante J.P., Peres M.F., Bernik M.A. Primary headaches in patients with generalized anxiety disorder. J Headache Pain. 2011; 12 (3) P. 331–338. DOI: 10.1007/s10194–010–0290–4.
28. Chutko L.S., Surushkina S. Yu., Yakovenko E.A., Anisimova T.I., Sergeev A.V. Emotional disorders and their correction in patients with migraine. Therapeutic Archive. 2017; 89 (4). P. 75–79.
29. Beghi E., Bussone G., D'Amico D., Cortelli P., Cevoli S., Manzoni G.C., Torelli P., Tonini M.C., Allais G., De Simone R., D'Onofrio F., Genco S., Moschiano F., Beghi M., Salvi S. Headache, anxiety and depressive disorders: the HADAS study. J Headache Pain. 2010; 11 (2) P. 141–150. DOI: 10.1007/s10194–010–0187–2.
30. Song T.J., Cho S.J., Kim W.J., Yang K.I., Yun C.H., Chu M.K. Anxiety and Depression in Tension-Type Headache: A Population-Based Study. PLoS One. 2016; 11 (10) P. e0165316. DOI: 10.1371/journal.pone.0165316.
31. Taylor D.J., Mallory L.J., Lichstein K.L., Durrence H.H., Riedel B.W., Bush A.J. Comorbidity of chronic insomnia with medical problems. Sleep. 2007; 30 (2) P. 213–218. DOI: 10.1093/sleep/30.2.213.
32. Brenes G.A., Miller M.E., Stanley M.A., Williamson J.D., Knudson M., McCall W.V. Insomnia in older adults with generalized anxiety disorder. Am J Geriatr Psychiatry. 2009; 17 (6) P. 465–472. DOI: 10.1097/jgp.0b013e3181987747.
33. Poluektov M.G., Pchelina P.V. Sleep disorders and anxiety. Effective Pharmacotherapy. 2017; 35. P. 4–13.
34. Volel B.A., Petelin D.S., Akhapkin R.V., Malyutina A.A. Cognitive impairment in anxiety disorders. Neurology, neuropsychiatry, psychosomatics. 2018; 10 (1). P. 78–82.
35. Amira N., Bomyea J. Working memory capacity in Generalized Social Phobia. J Abnorm Psychol. 2011; 120 (2) P. 504–509. DOI: 10.1037/a0022849.
36. Tsarenko D.M., Bobrov A.E. Cognitive impairment in organic and anxiety-depressive disorders in primary care patients. Crazy. Disorders in General Medicine. 2012; 1. P. 15–20.
37. Cisler J. M., Koster E. H. Mechanisms of attentional biases towards threat in anxiety disorders: an integrative review. Clin Psychol Rev. 2010; 30 (2) P. 203–16. DOI: 10.1016/j.cpr.2009.11.003.
38. Ren L., Yang Z., Wang Y., Cui L.B., Jin Y., Ma Z., Zhang Q., Wu Z., Wang H.N., Yang Q. The relations among worry, meta-worry, intolerance of uncertainty and attentional bias for threat in men at high risk for generalized anxiety disorder: A network analysis. BMC Psychiatry. 2020; 20 (1) P. 452. DOI: 10.1186/s12888–020–02849-w.
39. Chutko L.S., Surushkina S. Yu., Yakovenko E.A., Nikishena I.S., Anisimova T.I., Bondarchuk Yu.L. Cognitive impairment in patients with generalized anxiety disorder. Psychiatry and Psychopharmacotherapy n.a. P.B. Gannushkin. 2013; 3.
40. Pluzhnikov I.V. Emotional intelligence in affective disorders. Abstract of the dissertation for the degree of candidate of psychological sciences. Moscow; 2010.
41. Mayer J.D., Salovey P., Caruso D.R., Sitarenios G. Emotional intelligence as a standard intelligence. Emotion. 2001; 1 P. 232–242. https://doi.org/10.1037/1528–3542.1.3.232
42. Jacobs M., Snow J., Geraci M., Vythilingam M., Blair R. J., Charney D. S., Pine D. S., Blair K.S. Association between level of emotional intelligence and severity of anxiety in generalized social phobia. J Anxiety Disord. 2008; 22 (8) P. 1487–1495 DOI: 10.1016/j.janxdis.2008.03.003.
43. Gordeev S.A., Kovrov G.V., Posokhov S.I., Katenko S.V., Dyakonova N.A. Electroencephalographic correlates of psychovegetative syndrome in neurasthenia and generalized anxiety disorder. International Neurol. J. 2013; 2.
44. Kichuk I.V., Petrova E.A., Mitrofanov A.A., Solovieva N.V., Vilyanov V.B. Changes in electroencephalogram parameters and serotonin concentration in depressive and anxiety disorders. Neurology, neuropsychiatry, psychosomatics. 2016; 8 (3). P. 34–38.
45. Astashchenko A.P., Davydova E.V., Bogdanova V.A., Dorokhov E.V. Participation of the frontal parts of the brain in shifting attention to the emotional expressions of a person's face. Bulletin of psychophysiology. 2018; 1. P. 31–37.
46. Ellis A., Dryden W. The practice of rational-emotional behavioral therapy. Speech; 2002.
Review
For citations:
Chutko L.S., Yakovenko E.A., Surushkina S.Yu., Cherednichenko D.V. Neurological aspects of anxiety disorders. Medical alphabet. 2022;(10):7-11. (In Russ.) https://doi.org/10.33667/2078-5631-2022-10-7-11
Views:
419
Email this article 