Clinical experience of treatment patient with papillary thyroid cancer with retropharyngeal lymph node metastasis by targeted therapy

The aim. To present a clinical case of treatment of a patient with progressive papillary thyroid cancer in the form of metastatic lesion of the left retropharyngeal lymph node with the targeted drug lenvatinib.

Materials and methods. Clinical, laboratory, radiological and pathomorphological data of a 49-year-old male patient with verified papillary thyroid cancer with disease progression after initial treatment in the form of metastatic lesion of the left retropharyngeal lymph node

Results. A 49-year-old man of European origin, in March 2019, underwent surgical treatment in the volume of thyroidectomy with central and left-sided lateral lymph node dissection followed by radioiodintherapy with 3 Gbc activity for papillary cancer of the left thyroid lobe pT1N 1bM0. In October, according to the control examination, the progression of the disease in the form of metastatic lesion of the left retropharyngeal lymph node was registered. Since February 2020, by appointment of the multidisciplinary commission of the NMRC of Oncology n. a. N. N. Petrov (Moscow, Russia), currently, the patient is taking the targeted drug lenvatinib in a daily dose of 24 mg with satisfactory tolerability. According to control examinations, while taking the drug for 18 months, there was a partial response with a decrease in the size of the left retropharyngeal lymph node from 15 to 7 mm according to magnetic resonance imaging and a decrease in the activity (SUV_max) of the accumulation of 18F-glucose from 10.46 to 5.99.

Conclusion. The presented clinical case demonstrates a rare variant of metastasis of papillary thyroid cancer in the left retropharyngeal node and the result of treatment with the targeted drug lenvatinib on the background of taking for 18 months.

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