Evaluation of hemostasis parameters after mitral valve replacement surgery with mechanical prostheses in patients with different treatment adherence
https://doi.org/10.33667/2078-5631-2021-42-20-24
Abstract
The aim of the study. To analyze the indicators of hemostasis with adherence to treatment in patients operated on for mitral valve prosthetics with mechanical bicuspid prostheses in dynamics after 6, 12 and 60 months.
Materials and methods. The study included 260 patients who underwent surgery for prosthetics with mechanical prostheses. Patients’ adherence to treatment was assessed using the Morisky – Green test. The following hemostasis parameters were analyzed: international normalized ratio (INR), activated partial thromboplastin time (APTT), D-dimer, fibrinogen and soluble fibrin-monomer complexes.
Results of the study and conclusion. At all stages of the postoperative period, the hemostasis indicators of compliant patients corresponded to the reference values for people receiving anticoagulants, in non-compliant patients, these indicators did not reach the recommended values for patients on anticoagulant therapy. The presence of correlations between compliance and hemostasis indicators is evidenced by the results of correlation analysis. In most cases, the maximum strength of the relationship between compliance and hemostasis indicators was observed after 12 months of follow-up. A noticeable strength of interrelations was traced between compliance and levels of APTT, INR and fibrinogen.
About the Authors
M. M. Markova
Astrakhan State Medical University
Russian Federation
Russian Federation
Markova Margarita M., post-graduate student of Dept of Internal Diseases of Pediatric Faculty
Astrakhan
O. S. Polunina
Astrakhan State Medical University
Russian Federation
Russian Federation
Polunina Olga S., DM Sci (habil.), professor, head of Dept of Internal Diseases of Pediatric Faculty
Astrakhan
D. G. Tarasov
Astrakhan State Medical University
Russian Federation
Russian Federation
Tarasov Dmitry G., PhD Med, head of Dept of Cardiovascular Surgery of Faculty of Postgraduate Education
Astrakhan
M. A. Kiseleva
Regional Cardiology Dispensary
Russian Federation
Russian Federation
Kiseleva Maria A., PhD Med, chief physician
Astrakhan
E. A. Polunina
Astrakhan State Medical University
Russian Federation
Russian Federation
Polunina Ekaterina A., DM Sci (habil.), associate professor at Dept of Internal Diseases of Pediatric Faculty
Astrakhan
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Review
For citations:
Markova M.M., Polunina O.S., Tarasov D.G., Kiseleva M.A., Polunina E.A. Evaluation of hemostasis parameters after mitral valve replacement surgery with mechanical prostheses in patients with different treatment adherence. Medical alphabet. 2021;(42):20-24. (In Russ.) https://doi.org/10.33667/2078-5631-2021-42-20-24
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