Clinical and diagnostic value of the method of chromato-mass spectrometry of microbial markers in case of damage to the oral mucosa in children by rheumatic diseases
https://doi.org/10.33667/2078-5631-2021-38-49-57
Abstract
Due to the presence of a large percentage of 42.6% secondary oral infection in children with rheumatic diseases [1, 2], which arose during long-term treatment of shock and maintenance doses of anti-inflammatory therapy, it was important to study the microbiota [16, 17]. This paper for the first time applied a modern method for assessing the microbiota of various biotopes of the affected oral mucosa in children with rheumatic diseases – chromatosis-mass-spectrometry (CMSM), based on the quantitative determination of the level of markers of microorganisms: fatty acids, aldehydes, alcohols [5, 7, 10, 11]. СMSM is a highly sensitive method with a wide diagnostic spectrum. The study of a wide range of microorganisms provides new opportunities in the diagnosis of oral dysbacteriosis and increasing the effectiveness of individual treatment. The aim of the study is to improve the level of diagnosis and treatment of oral mucosal diseases in children with rheumatic diseases, through the use of chromato-mass-spectrometry of the oral microbiota.
About the Authors
A. A. Skakodub
Federal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University»
of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Skakodub Alla A., PhD, assistant professor of dentistry in the Department of Pediatric Dentistry and Orthodontics
Moscow
O. I. Admakin
Federal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University»
of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Admakin Oleg I., MD, Head of the Department of Prevention and Public Dental Health
Moscow
Ad. A. Mamedov
Federal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University»
of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Mamedov Adil A., MD, Head of the Department of Pediatric Dentistry and Orthodontics
Moscow
N. A. Geppe
Federal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University»
of the Ministry of Health of the Russian Federation (Sechenov University)
Russian Federation
Russian Federation
Geppe Natalia A., MD, Head of the of Department of Childhood diseases
Moscow
A. V. Simonova
Moscow Regional Research Clinical Institute named after M.F. Vladimirsky
Russian Federation
Russian Federation
Simonova Albina V., MD, professor of the Department of General Medical Practice
Moscow
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For citations:
Skakodub A.A., Admakin O.I., Mamedov A.A., Geppe N.A., Simonova A.V. Clinical and diagnostic value of the method of chromato-mass spectrometry of microbial markers in case of damage to the oral mucosa in children by rheumatic diseases. Medical alphabet. 2021;1(38):49-57. (In Russ.) https://doi.org/10.33667/2078-5631-2021-38-49-57
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