Drug-induced agranulocytosis (clinical observation)
https://doi.org/10.33667/2078-5631-2021-30-19-23
Abstract
The majority of agranulocytosis cases are caused by drugs, including nonsteroidal anti-inflammatory drugs, antibiotics, antithyroid agents, etc. Here, we report a case of severe agranulocytosis in a 67-year-old woman following nonsteroidal anti-inflammatory therapy which was successfully managed using recombinant human granulocyte colony-stimulating factor. Although metamizole, has been in use since 1922 in the management of postoperative pain, colic pain, cancer pain and migraine, agranulocytosis as a direct side effect of metamizole therapy has been rarely reported. It is important to keep in mind this rare but potentially life-threatening adverse effect of metamizole, when initiating therapy.
About the Authors
N. A. Sokolova
Russian National Research Medical University n. a. N. I. Pirogov
Russian Federation
Russian Federation
Sokolova Natalia A., PhD Med, associate professor at Dept of Clinical Laboratory Diagnostics, Faculty of Additional Postgraduate Education
Moscow
L. V. Pozdnyakova
Medical and Sanitary Unit No. 152 of the Federal Medical and Biological Agency
Russian Federation
Russian Federation
Pozdnyakova Lyudmila V., PhD Med, physician of superior expert category, head
of Hematology Dept
Moscow Region, Dzerzhinsky
I. S. Tatarinova
Medical and Sanitary Unit No. 152 of the Federal Medical and Biological Agency
Russian Federation
Russian Federation
Tatarinova Inna S., head of Clinical Diagnostic Laboratory
Moscow Region, Dzerzhinsky
References
1. Lorenzo-Villalba N., Alonso-Ortiz M.B., Maouche Y., Zulfqar A.-A., and Andrès E. Idiosyncratic Drug-Induced Neutropenia and Agranulocytosis in Elderly Patients. J. Clin. Med. 2020; (9): 1808. https://doi.org/10.3390/jcm9061808
2. Clinical practice guidelines for the diagnosis and treatment of acquired neutropenia. Year of approval 2018. https://legalacts.ru/doc/klinicheskie-rekomendatsii-priobretennye-neitropenii-utv-minzdravom-rossii/
3. Kubota Y., Wong T. Y.E. Severe drug-induced agranulocytosis successfully treated with recombinant human granulocyte colony-stimulating factor. Case Rep. Med. 2018; pp. 10–12. https://doi.org/10.1155/2018/8439791
4. Pediatric Hematology / Oncology (ed. by Rumyantsev A.G. and Samochatova E.V.). M.: MEDPRACTICA-M. 2004; 792 p.
5. Alekseev N. A. Clinical aspects of leukopenia, neutropenia and functional disorders of neutrophils. SPb.: Folio. 2002; 416 p.
6. Deordieva E.A., Shcherbina A. Yu. Neutropenia in the practice of a pediatric hematologist / oncologist. Oncohematology. 2015; (1): 47–52.
7. Yudina N.B., Brezhneva N.V. Isolated neutropenia in children: from pediatrician to hematologist (literature review). Russian Journal of Pediatric Hematology and Oncology. 2015; (1): 75–80.
8. Cismaru A.L., Grimm L., Rudin D., Ibañez L., Liakoni E., Bonadies N., Kreutz R., Hallberg P., Wadelius M.; EuDAC Collaborators, Haschke M., Largiadèr C.R., Amstutz U. High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis. Front Genet. 2020 Aug 21; (11): 951. https://doi.org/10.3389/fgene.2020.00951
9. Rudin D., Lanzilotto A., Bachmann F., Housecroft C.E., Constable E.C., Drewe J., Haschke M., Krähenbühl S. Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells. Biochem Pharmacol. 2019; (163): 345–356. https://doi.org/10.1016/j.bcp.2019.01.011
Review
For citations:
Sokolova N.A., Pozdnyakova L.V., Tatarinova I.S. Drug-induced agranulocytosis (clinical observation). Medical alphabet. 2021;1(30):19-23. (In Russ.) https://doi.org/10.33667/2078-5631-2021-30-19-23
Views:
802
Email this article 