Cardiotoxicity with antihypertensive drugs (literature review) Part 1. Calcium channel blockers and beta-blockers
https://doi.org/10.33667/2078-5631-2021-25-12-19
Abstract
The effect of hypotensive drugs overdose on cardiovascular system is poorly studied; it should undergo clinical, experimental pharmacology and toxicology together with cardiology. There is too little information about cardiotoxicity of beta-blockers (β-blockers) and calcium channel blockers (CCB) in existing research literature. Intoxication from these groups of drugs causes similar severe hemodynamic abnormalities and myocardial insufficiency, however pathophysiological mechanisms of these abnormalities are not thoroughly studied. The review highlights how difficult it is to identify toxic level and distinctive features of clinical evidence of intoxication. Methods of diagnosis as well as β-blockers and CCB overdose treatment are discussed.
About the Authors
A. N. Esaulenko
Research Institute of Emergency Care n. a. N. V. Sklifosovsky
Russian Federation
Russian Federation
Esaulenko Anna N., clinical intern with degree in Cardiology
Moscow
A. Yu. Moiseeva
Research Institute of Emergency Care n. a. N. V. Sklifosovsky
Russian Federation
Russian Federation
Moiseeva Alexandra Yu., clinical intern with degree in Cardiology
Moscow
A. A. Ivannikov
Research Institute of Emergency Care n. a. N. V. Sklifosovsky
Russian Federation
Russian Federation
Ivannikov Alexander A., clinical intern with degree in Cardiology
Moscow
I. V. Bratischev
Research Institute of Emergency Care n. a. N. V. Sklifosovsky
Russian Federation
Russian Federation
Bratishchev Igor V., anesthesiologist-resuscitator, teacher of Training Centre
Moscow
Kh. G. Alidzhanova
Research Institute of Emergency Care n. a. N. V. Sklifosovsky
Russian Federation
Russian Federation
Alidzhanova Khafiza G., DM Sci, chief teacher at Training Centre
Moscow
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Review
For citations:
Esaulenko A.N., Moiseeva A.Yu., Ivannikov A.A., Bratischev I.V., Alidzhanova Kh.G. Cardiotoxicity with antihypertensive drugs (literature review) Part 1. Calcium channel blockers and beta-blockers. Medical alphabet. 2021;(25):12-19. (In Russ.) https://doi.org/10.33667/2078-5631-2021-25-12-19
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